Influence of supramolecular layer-crosslinked structure on stability of dual pH-Responsive polymer nanoparticles for doxorubicin delivery

Feng, Hailiang; Sun, Yu; Zhang, Jianhua; Deng, Liandong; Dong, Anjie

doi:10.1016/j.jddst.2018.03.008

Cited by 9 publications

(9 citation statements)

References 48 publications

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“…To enhance the stability of nanoparticles in vivo, one strategy is to stabilize them by crosslinking . Crosslinking can be through covalent bonds or non‐covalent interactions, such as host–guest interaction between β‐cyclodextrin (β‐CD) and benzimidazole (BM) . For some applications irreversible crosslinking may be disadvantageous as it can limit the ability to release drug at the target cells.…”

Section: Crosslinking In Ph‐responsive Nanoparticlesmentioning

confidence: 93%

“…Recently, these materials have been applied to the design of pH‐responsive nanoparticles. Deng and co‐workers synthesized particles based on the combination of two polymers, poly((methacrylic acid betaine) methyl methacrylate)‐ b ‐poly(single 6‐methyl acryloyl ethylenediamine β‐cyclodextrin‐ b ‐poly(benzimidazole ethyl methacrylate)‐ b ‐poly(diisopropylamino) ethyl methacrylate) (PCB‐ b ‐PCD‐ b ‐PDPAEMA) and poly((methacrylic acid betaine) methyl methacrylate)‐ b ‐poly(benzimidazole ethyl methacrylate)‐ b ‐poly(diisopropylamino) ethyl methacrylate) (PCB‐ b‐ PBM‐ b ‐PDPAEMA) . To form crosslinked particles, both polymers were employed while non‐crosslinked particles involved just a single polymer (PCB‐ b ‐PCD‐ b ‐PDEAEMA).…”

Section: Crosslinking In Ph‐responsive Nanoparticlesmentioning

confidence: 99%

“…The pH‐responsive PDPAEMA (p K a ≈ 6.3) acted as the core, hydrophilic PCB acted as the shell, and the pH‐responsive host–guest complex was based on β‐CD and BM (p K a < 6.0). Nanoparticles were made through solvent evaporation method and crosslinked based on host–guest recognition between β‐CD (β‐cyclodextrin) and BM (benzimidazole) . Below pH 6.0, the amino groups of BM (p K a < 6.0) are protonated which makes the host–guest complexes unstable and thus the particles disassembled .…”

Section: Crosslinking In Ph‐responsive Nanoparticlesmentioning

confidence: 99%

See 2 more Smart Citations

pH‐Responsive Polymer Nanoparticles for Drug Delivery

Deirram

Zhang

Kermaniyan

et al. 2019

Macromol. Rapid Commun.

385

264

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Stimuli‐responsive nanoparticles have the potential to improve the delivery of therapeutics to a specific cell or region within the body. There are many stimuli that have shown potential for specific release of cargo, including variation of pH, redox potential, or the presence of enzymes. pH variation has generated significant interest for the synthesis of stimuli‐responsive nanoparticles because nanoparticles are internalized into cells via vesicles that are acidified. Additionally, the tumor microenvironment is known to have a lower pH than the surrounding tissue. In this review, different strategies to design pH‐responsive nanoparticles are discussed, focusing on the use of charge‐shifting polymers, acid labile linkages, and crosslinking.

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Section: Crosslinking In Ph‐responsive Nanoparticlesmentioning

confidence: 93%

Section: Crosslinking In Ph‐responsive Nanoparticlesmentioning

confidence: 99%

Section: Crosslinking In Ph‐responsive Nanoparticlesmentioning

confidence: 99%

See 1 more Smart Citation

pH‐Responsive Polymer Nanoparticles for Drug Delivery

Deirram

Zhang

Kermaniyan

et al. 2019

Macromol. Rapid Commun.

385

264

View full text Add to dashboard Cite

show abstract

“…The supramolecular crosslinked shell endows the NPs with both stability in the bloodstream and pH‐responsive ability in the tumoral environment. Under acidic conditions, loaded DOX was rapidly released from the NPs due to the disintegration of the supramolecular crosslinked shell …”

Section: Stimuli‐responsive Drug‐release Nanosystemsmentioning

confidence: 99%

Strategies To Design and Synthesize Polymer‐Based Stimuli‐Responsive Drug‐Delivery Nanosystems

Qin

2020

ChemBioChem

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The emergence and development of nanomedicine have alleviated problems existing in traditional chemotherapy drugs, such as short lifetime, concomitant side effects, and weak tumor‐targeting capability. Nevertheless, the further applications of drug‐loaded nanocarriers are still limited by their premature leakage, weak targeting capability, and insufficient intracellular release. In past decades, various nanocarriers, including gold nanoparticles, porous silica nanoparticles, carbon‐based nanoparticles, micelles, liposomes, and polymer–drug conjugates, have been intensively investigated for tumor therapy. Among these, polymer‐based nanocarriers have attracted more attention due to their biocompatibilities and capability of being modified for stimuli‐responsive drug release. In this review, three popular strategies to design and synthesize polymer‐based stimuli‐responsive nanocarriers are discussed. The discussion goes from stimuli‐responsive polymers with responsive backbones or modified by responsive functional groups for drug encapsulation and release to polymer–drug conjugates with responsive covalent linkages. In particular, due to the facile synthetic processes and mild reaction conditions for crosslinked structures, the latest progress in responsive crosslinked structures is emphasized. Finally, future perspectives for these nanomaterials are given, which are expected to provide inspiration for researchers to design more effective and safer tumor‐killing nanomedicines.

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“…Recently, pH-sensitive polymers have been gaining attention for applications in drug delivery [ 49 ] and cancer therapy [ 50 ].…”

Section: Ph Responsive Polymersmentioning

confidence: 99%

Stimuli Responsive Polymeric Systems for Cancer Therapy

et al. 2018

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Nanoscale polymers systems have dominated the revolution of drug delivery advancement. Their potential in the fight against cancer is unrivalled with other technologies. Their functionality increase, targeting ability and stimuli responsive nature have led to a major boom in research focus. This review article concentrates on the use of these smart polymers in cancer therapy. Nanotechnologies have shown potential as drug carriers leading to increased drug efficacy and penetration. Multifunctional smart carriers which can release their payload upon an external or internal trigger such as pH or temperature are proving to be major frontrunners in the development of effective strategies to overcome this disease with minimal patient side effects.

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Influence of supramolecular layer-crosslinked structure on stability of dual pH-Responsive polymer nanoparticles for doxorubicin delivery

Cited by 9 publications

References 48 publications

pH‐Responsive Polymer Nanoparticles for Drug Delivery

pH‐Responsive Polymer Nanoparticles for Drug Delivery

Strategies To Design and Synthesize Polymer‐Based Stimuli‐Responsive Drug‐Delivery Nanosystems

Stimuli Responsive Polymeric Systems for Cancer Therapy

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