Influence of Synthetic Analog  of Platelet Activation Factor  1-Alkyl-2-Alkylcarbomoilglicerine  on Vascular Smooth Muscle Cells  Contractile Properties

The study describes the synthesis and hypotensive effects of stable platelet activation factor (PAF) precursor 1-hexadecyl-2-m ethylcarbamoyl-phosphatidic acid (HMCP) оn outbred Wistar rats with 1-kidney 1-clip (1K1C) renovascular hypertension. Intravenous injection of 0.1, 0.5, 1 and 5 mg/kg HMCP resulted in a sharp decline of up to 50% of MAP with subsequent restoration to initial level. In some hypertensive 1K1C rats HMCP has a prolonged effect with blood pressure stabilized at 75% of initial level after 30 min post injection. HMCP was toxic at higher doses with a LD50 around 3 mg/kg.

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Hypotensive effect of bi-potassium salt of 1-hexadecyl-2-methylcarbamoylphosphatidic acid in rats with renovascular hypertension

Хромова

Malekin

Гаврилова

et al. 2018

Bûll. sib. med.

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Influence of Synthetic Analog of Platelet Activation Factor 1-Alkyl-2-Alkylcarbomoilglicerine on Vascular Smooth Muscle Cells Contractile Properties

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Hypotensive effect of bi-potassium salt of 1-hexadecyl-2-methylcarbamoylphosphatidic acid in rats with renovascular hypertension

Hypotensive effect of bi-potassium salt of 1-hexadecyl-2-methylcarbamoylphosphatidic acid in rats with renovascular hypertension

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