Influence of temperature on the solubilization of thiabendazole by combined action of solid dispersions and co-solvents

Muela, Susana; Escalera, Begoña; Peña, María Ángeles; Bustamante, Pilar

doi:10.1016/j.ijpharm.2009.10.001

Cited by 24 publications

(10 citation statements)

References 23 publications

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“…Solubility enhancement is traditionally achieved by various processes such as salt formation, co-solvents, complexation, and solid dispersion to name a few. These techniques, however, suffer from uncontrolled precipitation, solvent toxicity and stability concerns [3][4][5][6]. The main emphasis for solubility enhancement till date in the pharmaceutical fraternity relies on particle size reduction, as reflected by Ostwald-Freundlich equation [7].…”

Section: Introductionmentioning

confidence: 99%

Modulating in vitro release and solubility of griseofulvin using functionalized mesoporous silica nanoparticles

Jambhrunkar

Popat

et al. 2014

Journal of Colloid and Interface Science

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Section: Introductionmentioning

confidence: 99%

Modulating in vitro release and solubility of griseofulvin using functionalized mesoporous silica nanoparticles

Jambhrunkar

Popat

et al. 2014

Journal of Colloid and Interface Science

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“…TBZ will be accumulated in human body, and its potential toxic residues in edible animals and plant origin products may pose a great threat to human health through the food chain. To ensure the safety of food for consumers, numerous legislations have established maximum residue limits for TBZ in foodstuff, which range from 5 to 10 mg/kg depending on the country (Japan, USA, Europe) (Muela et al 2010;Juan et al 2006;García-Reyes et al 2006). Moreover, TBZ application to fruits and vegetables may also affect the quality of environmental resources such as groundwater and surface water.…”

Section: Introductionmentioning

confidence: 99%

An Electrochemical Method for High Sensitive Detection of Thiabendazole and Its Interaction with Human Serum Albumin

et al. 2014

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In this study, a simple and highly sensitive electroanalytical method for the determination of thiabendazole (TBZ) was developed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at carboxyl-functionalized multiwalled carbon nanotubes (MWCNT-COOH) modified glassy carbon electrode (MWCNT-COOH/GCE) in phosphate buffer solution (pH=6.0). MWCNT-COOH/GCE exhibits an enhanced effectiveness for the redox of TBZ. This constructed biosensor exhibited two linear relationships with TBZ concentration range from 5.00×10 −7 to 4.95×10 −6 mol/L and 4.95×10 −6 to 9.80×10 −5 mol/L, respectively. The detection limit was 3.0×10 −7 mol/L (S/N=3) and the relative standard deviation (R.S.D.) was lower than 4.2 % (n=6). The proposed method was successfully applied to determine TBZ in real samples and the results were satisfactory. The MWCNT-COOH/GCE electrode showed good reproducibility, stability, and anti-interference. The electrochemistry method was also described for the evaluation of TBZ and human serum albumin (HSA) interaction. In the presence of HSA, the peak currents of TBZ decreased linearly due to the formation of a kind of electro-inactive complex. The binding constant between TBZ and HSA was obtained by DPV.

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“…To enhance the solubilizing capability of carriers, various solubilizing and emulsifying pharmaceutical excipients, such as solubilizers, surfactants, oils and fatty acids can be incorporated into SDs (Joshi et al, 2004;Heo et al, 2005;Vasconcelos et al, 2007;Sancheti et al, 2009;Muela et al, 2010). Hydroxypropyl methylcellulose (HPMC) is particularly interesting for this purpose; it is a semisynthetic, nonionic cellulose ether that is widely used in coating and at controlled-release dosages (Velasco et al, 1999;Conti et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of emulsified solid dispersions containing docetaxel

et al. 2011

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An emulsified solid dispersion of docetaxel was prepared and characterized in vitro. In contrast to conventional solid dispersions, emulsifying pharmaceutical excipients and hydroxypropyl methylcellulose (HPMC) as a supersaturation promoter were introduced into the PEG6000-based solid dispersion to further improve its solubilizing capability. The solubility, dissolution in vitro and stability of the prepared emulsified solid dispersions were studied taking into consideration of the effects of different emulsifying excipients, preparation methods and the media. Results of the emulsified solid dispersion of docetaxel showed that the solubility and dissolution at 2 h were 34.2- and 12.7-fold higher than the crude powder. The type of emulsifying excipient used had a significant influence on the dissolution of the emulsified solid dispersion. The dissolution of the emulsified solid dispersion prepared by the solvent-melting method or the solvent method was higher than the melting method. There were no apparent differences among the dissolution media utilized. The status of the drug in the emulsified solid dispersion was observed in an amorphous or a molecular dispersion state by differential thermal analysis and powder Xray diffraction. In conclusion, the incorporation of emulsifying pharmaceutical excipients and HPMC with polymers into a solid dispersion could be a new and useful tool to greatly increase the solubility and dissolution of poorly water-soluble drugs.

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Influence of temperature on the solubilization of thiabendazole by combined action of solid dispersions and co-solvents

Cited by 24 publications

References 23 publications

Modulating in vitro release and solubility of griseofulvin using functionalized mesoporous silica nanoparticles

Modulating in vitro release and solubility of griseofulvin using functionalized mesoporous silica nanoparticles

An Electrochemical Method for High Sensitive Detection of Thiabendazole and Its Interaction with Human Serum Albumin

Preparation and characterization of emulsified solid dispersions containing docetaxel

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