Based on the upper bound theorem of limit analysis (UBLA) combined with the pseudostatic methods, this paper elaborates on a calculated procedure for evaluating fissured slope stability under seismic conditions reinforced with prestressed anchor cables. An existing simple slope case is presented as a case study in this work. The comparison is given to verify that the solution derived from this study is correct and feasible. By means of a numerical optimization procedure, the critical location of the crack is determined from the best upper bound solutions. The results demonstrate a significant influence of the depth of crack and seismic acceleration coefficient on the critical location distribution of the cracks. Meanwhile, the axial force of anchor cables is investigated via parametric studies. It is shown that the variation of the crack depth has little effect on the axial force of anchor cables. Moreover, this paper also illustrates the variation in the axial force of anchor cables under the impact of five marked factors (crack depth, anchor arrangement, anchor inclination angle, slope angle, and seismic conditions). Finally, the required critical length of the free section of anchor cables is determined to ensure the stability of fissured slopes subjected to seismic action.