Influence of the body mass index on the occurrence of falls in patients with type 2 diabetes mellitus

Herrera-Rangel, Aline B.; Aranda-Moreno, Catalina; Mantilla-Ochoa, Teresa; Zainos-Saucedo, Lilia; Jáuregui‐Renaud, Kathrine

doi:10.1016/j.orcp.2015.02.006

Cited by 20 publications

(10 citation statements)

References 23 publications

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“…When the presence of retinopathy was analyzed, it was seen that the differences of BMI between the T2DMG+DR and T2DMG−DR were not significant (28.8 + 4.7 kg/m 2 versus 28.0 + 4.0 kg/m 2 ; p = 0.345). In agreement with these data, it has been reported that BMI in correlation with HbA1c, HBP, and cholesterol seems to be related to DR progression in T2DM patients [ 36 ]. Furthermore, it has been suggested that BMI may be considered as a predictive marker for the development and progression of DR [ 36 , 37 ].…”

Section: Discussionsupporting

confidence: 85%

“…In agreement with these data, it has been reported that BMI in correlation with HbA1c, HBP, and cholesterol seems to be related to DR progression in T2DM patients [ 36 ]. Furthermore, it has been suggested that BMI may be considered as a predictive marker for the development and progression of DR [ 36 , 37 ]. In addition to the carbohydrate restriction, dietary recommendations on this topic include saturated fat restriction (<7% of daily caloric intake) and cholesterol restriction (<200 mg/dL) among diabetics.…”

Section: Discussionsupporting

confidence: 85%

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Enhanced Oxidative Stress and Other Potential Biomarkers for Retinopathy in Type 2 Diabetics: Beneficial Effects of the Nutraceutic Supplements

Roig-Revert

Lleó-Pérez

Zanón‐Moreno

et al. 2015

BioMed Research International

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We have studied the global risk of retinopathy in a Mediterranean population of type 2 diabetes mellitus (T2DM) patients, according to clinical, biochemical, and lifestyle biomarkers. The effects of the oral supplementation containing antioxidants/omega 3 fatty acids (A/ω3) were also evaluated. Suitable participants were distributed into two main groups: (1) T2DMG (with retinopathy (+DR) or without retinopathy (−DR)) and (2) controls (CG). Participants were randomly assigned (+A/ω3) or not (−A/ω3) to the oral supplementation with a daily pill of Nutrof Omega (R) for 18 months. Data collected including demographics, anthropometrics, characteristics/lifestyle, ophthalmic examination (best corrected visual acuity, ocular fundus photographs, and retinal thickness as assessed by optical coherence tomography), and blood parameters (glucose, glycosylated hemoglobin, triglycerides, malondialdehyde, and total antioxidant capacity) were registered, integrated, and statistically processed by the SPSS 15.0 program. Finally, 208 participants (130 diabetics (68 +DR/62 −DR) and 78 controls) completed the follow-up. Blood analyses confirmed that the T2DMG+DR patients had significantly higher oxidative stress (p < 0.05), inflammatory (p < 0.05), and vascular (p < 0.001) risk markers than the T2DMG−DR and the CG. Furthermore, the A/ω3 oral supplementation positively changed the baseline parameters, presumptively by inducing metabolic activation and ameliorating the ocular health after 18 months of supplementation.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 85%

Enhanced Oxidative Stress and Other Potential Biomarkers for Retinopathy in Type 2 Diabetics: Beneficial Effects of the Nutraceutic Supplements

Roig-Revert

Lleó-Pérez

Zanón‐Moreno

et al. 2015

BioMed Research International

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“…Increased risk of falling in individuals with diabetes has been demonstrated in a number of studies . In addition to the effect of obesity in increasing the risk of falls diabetic co‐morbidities also contribute, these include visual impairment due to cataracts or retinopathy, cardiac arrhythmias due to cardiovascular disease, and peripheral neuropathy.…”

Section: Pathogenesis Of Fractures Associated With T2dmmentioning

confidence: 99%

Type 2 diabetes mellitus and bone

2018

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Type 2 diabetes (T2DM) is a rapidly growing public health problem. It is associated with an increased risk of fracture, particularly of the hip, despite normal or high bone mineral density. Longer duration of disease and poor glycaemic control are both associated with higher fracture risk. The factors underlying increased fracture risk have not been clearly established, but increased falls risk, obesity, sarcopenia and co‐morbidities are likely to contribute. The basis for reduced bone strength despite higher bone mineral density remains to be fully elucidated. Bone turnover is reduced in individuals with T2DM, with evidence of impaired bone formation. Most studies indicate normal or superior trabecular bone structure although reduced lumbar spine trabecular bone score (TBS) has been reported. Deficits in cortical bone structure have been demonstrated in some, but not all, studies whilst reduced bone material strength index (BMSi), as assessed by microindentation, has been a consistent finding. Accumulation of advanced glycation end products in bone may also contribute to reduced bone strength. The use of FRAX in individuals with T2DM underestimates fracture probability. Clinical management should focus on falls prevention strategies, avoidance of known risk factors, maintenance of good glycaemic control and bone protective intervention in individuals at high risk of fracture. Dietary and surgical strategies to reduce weight have beneficial effects on diabetes but may have adverse effects on skeletal health. Future research priorities include better definition of the mechanisms underlying increased fracture risk in T2DM and optimal strategies for identifying and treating those at high risk.

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“…Study of Herrera-Rangel et al on "Influence of the body mass index on the occurrence of falls in patients with type 2 diabetes mellitus" in this the occurrence of falls was related to BMI, gender and age. Compared to patients with no falls, patients with falls had a greater BMI [21].…”

Section: Study Of Hannah Et Al On "Biomechanical Effects Of Obesity Onmentioning

confidence: 86%

Association between Physical Functioning and Fear of Falling with Balance in Elderly Diabetic Individuals

Sankhe¹,

Ganvir²

2017

Physiother Rehabil

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Background: Diabetes mellitus is a highly prevalent metabolic disease, particularly in the elderly population. Diabetic peripheral neuropathy (DPN), the most common complication, is present in up to half of the people with diabetes, leading to sensory and autonomic motor impairment, and possibly increasing the risk of falling. DM is also associated with geriatric conditions falls, incontinence, low body mass index, dizziness, vision, hearing and cognitive impairments and dependence on activities of daily living. Balance is one of the major factors which associated with falls in the elderly population. Diabetes in addition may cause further damage to the nervous system thereby resulting in impaired balance leading to increased risk of falls. It is essential to investigate relationship between balances and falls in diabetic individuals.

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Influence of the body mass index on the occurrence of falls in patients with type 2 diabetes mellitus

Cited by 20 publications

References 23 publications

Enhanced Oxidative Stress and Other Potential Biomarkers for Retinopathy in Type 2 Diabetics: Beneficial Effects of the Nutraceutic Supplements

Enhanced Oxidative Stress and Other Potential Biomarkers for Retinopathy in Type 2 Diabetics: Beneficial Effects of the Nutraceutic Supplements

Type 2 diabetes mellitus and bone

Association between Physical Functioning and Fear of Falling with Balance in Elderly Diabetic Individuals

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