Influence of the Liver on the Shock Produced by Extracts of Certain Parasites

Studies on the Circulatory Changes in the Dog Produced by Endotoxin From Gram-Negative Microorganisms

“…Endo-toxins from gram-negative bacteria probably exert a similar action. This is supported by the observation that portal-caval anastomosis (Eck fistula) greatly modifies the immediate hypotensive reaction that follows injection of endotoxin, parasitic extracts, or anaphylaxis (9,31,32). However, the hepatovascular phenomena which occur in various types of shock are as yet poorly understood.…”

Endotoxin Shock in Pregnancy

“…They suggested the reaction of endotoxin was at least partially a result of anaphylaxis. Grana [18] made the same observa tion using H ydatid fluid or ascaris extract. He found th at a hepatic vascular spasm was chiefly responsible for the hypotension and th at the ascaris extract had no effect on the blood pressure in the hepat ectomized dogs.…”