Influence of the nature of the solid support and the dispersity of the active agent on the performance of chromatographic columns packed with surface-layer sorbents

Abstract

SummaryRetention ability of different types of solid supports with respect to active agents was studied using NaXtype zeolites as the example. The relative contribution of the zeolite (active agent) and the solid support to the overall adsorption of certain hydrocarbons was determined. The role of dispersity (particle size) and depth of penetration of the active agent in the pores of the solid support was investigated, using the uniformity criterion A of Vigdergauz. The performance of chromatographic columns packed by surface-layer sorbents is compared with columns packed with the pure active agent.

Use of surface modified natural zeolite (SMNZ) in pharmaceutical preparations Part 1. Mineralogical and technological characterization of some industrial zeolite-rich rocks

“…Currently, some other tangible proposals for the use of zeolite-rich rocks open new scenarios in the veterinarian and pharmaceutical sectors. Data from literature in the field provide evidence that the alkaline composition, molecular absorption, and cation exchange properties (external and internal) of zeolites induce positive therapeutic effects [2][3][4][5][6]. Moreover, these properties proved effective in the treatment of some pathologies, or as antidiarrhoic or antibacteric agents such as biosensors and decontaminants [4].…”