Influence of the pH value and the surfactant concentration on the pumping performance of magnesium fuel based Janus micropumps

Zhao, Zewei; Wu, Zhiguang; Rutkowski, Sven; Tverdokhlebov, Sergei I.; Frueh, Johannes

doi:10.1016/j.colsurfa.2021.127081

Cited by 7 publications

(4 citation statements)

References 40 publications

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“…Furthermore, the proposed lithography-assisted semishell NP synthesis method is versatile and has the potential to fabricate different Janus NPs for wider applications, such as nanoscale Janus motors. 42 4. EXPERIMENTAL SECTION 4.1.…”

Section: Discussionmentioning

confidence: 99%

Semishell Janus Nanoparticle-Enabled pH-Responsive Rod-Shaped Assembly for Photothermal Therapy

García

et al. 2021

ACS Appl. Nano Mater.

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The controllable aggregation of nanoparticles in solution is an important but unsolved problem in nanotechnology, which is mainly hindered by the symmetrical structure of the nanoparticles. Here, we propose an anisotropic semishell nanostructure to achieve the rod-shaped assembly of nanoparticles in solution. The isotropic Au@silica core–shell nanoparticles are self-assembled on the silicon wafer by the drop-casting technique to form a monolayer film. Au@silica semishell nanoparticles are obtained after selectively removing part of the silica shell by reactive ion etching. After functionalization with pH-sensitive 4-mercaptobenzoic acid molecules, the semishell nanoparticles display pH-responsive localized surface plasmon resonance coupling and near-infrared light absorption, thereby holding great potential for noninvasive photothermal therapy.

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Section: Discussionmentioning

confidence: 99%

Semishell Janus Nanoparticle-Enabled pH-Responsive Rod-Shaped Assembly for Photothermal Therapy

García

et al. 2021

ACS Appl. Nano Mater.

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“…Differently shaped polymer Janus particles have been prepared by phase separation, self‐assembly or microfluidic strategies. [ 42‐44 ] Such particles performed excellently in various fields, including biomedical applications, due to their multifunctional properties and relative ease of further modification. [ 43 ]…”

Section: Types Of Anisotropic Drug Delivery Vesiclesmentioning

confidence: 99%

“…Differently shaped polymer Janus particles have been prepared by phase separation, self-assembly or microfluidic strategies. [42][43][44] Such particles performed excellently in various fields, including biomedical applications, due to their multifunctional properties and relative ease of further modification. [43] Patchy particle fabrication is an alternative approach where distinct regions with different surface properties of the carrier can be used to control interactions with cells or tissues.…”

Section: Types Of Anisotropic Drug Delivery Vesiclesmentioning

confidence: 99%

Features of Anisotropic Drug Delivery Systems

Kudryavtseva,

Sukhorukov

2024

Advanced Materials

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Natural materials are anisotropic. Delivery systems occurring in nature, such as viruses, blood cells, pollen, and many others, do have anisotropy, while delivery systems made artificially are mostly isotropic. There is apparent complexity in engineering anisotropic particles or capsules with micron and submicron sizes. Nevertheless, some promising examples of how to fabricate particles with anisotropic shapes or having anisotropic chemical and/or physical properties have been developed. Anisotropy of particles, once they face biological systems, influences their behaviour. Internalisation by the cells, flow in the bloodstream, biodistribution over organs and tissues, directed release, and toxicity of particles regardless of the same chemistry are all reported to be factors of anisotropy of delivery systems. Here, we review the current methods to introduce anisotropy to particles or capsules, including loading with various therapeutic cargo, variable physical properties primarily by anisotropic magnetic properties, controlling directional motion, and making Janus particles. The advantages of combining different anisotropy in one entity for delivery and common problems and limitations for fabrication are under discussion.This article is protected by copyright. All rights reserved

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“…In an ethanol-treated rat stomach, about 50% of the ulcer–adhesive keratin hydrogel can reside within 12 h, while only about 18% of it can do so in an untreated rat stomach [ 26 ]. Additionally, Keratin hydrogels expedited the repair of the ethanol-induced stomach ulcer by halting the bleeding, shielding the epithelial cells from destruction by gastric acid, reducing inflammation and encouraging re-epithelization [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Polymeric Hydrogels Containing Esomeprazole for Oral Delivery: In Vitro and In Vivo Pharmacokinetic Characterization

et al. 2023

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Hydrogel is one of the most interesting and excellent candidates for oral drug delivery. The current study focuses on formulation development of hydrogels for controlled oral delivery of esomeprazole. The hydrogels were prepared by solution casting method by dissolving polymers in Polyvinyl alcohol (PVA) solution. Calcium alginate, Hydroxyl propyl methylcellulose (HPMC), acrylic acid and chondroitin sulfate were used in the preparation of hydrogels. Fourier transform infrared (FTIR) analysis showed no incompatibilities between drug and excipients used in the preparation of formulations. The hydrogels were characterized for size and surface morphology. Drug encapsulation efficiency was measured by Ultraviolet-visible (UV-VIS) spectroscopy. In vitro release studies were carried out using dissolution apparatus. The formulated hydrogels were then compared with the marketed product in vivo using rabbits. The result indicates that prepared hydrogels have a uniform size with a porous surface. The esomeprazole encapsulation efficiency of the prepared hydrogels was found to be 83.1 ± 2.16%. The esomeprazole-loaded hydrogel formulations showed optimum and Pharmacopeial acceptable range swelling behavior. The release of esomeprazole is controlled for 24 h (85.43 ± 0.32% in 24 h). The swelling and release of drug results make the prepared hydrogels a potential candidate for the controlled delivery of esomeprazole. The release of the drug from prepared hydrogel followed the super case transport-2 mechanism. The in vivo studies showed that prepared hydrogel formulations showed controlled and prolonged release of esomeprazole as compared to drug solution and marketed product. The formulations were kept for stability studies; there was no significant change observed in physical parameters, i.e., (appearance, color change and grittiness) at 40 °C ± 2/75% ± RH. There was a negligible difference in the drug content observed after the stability study suggested that all the formulations are stable under the given conditions for 60 days. The current study provides a valuable perspective on the controlled release profile of Hydroxyl propyl methylcellulose (HPMC) and calcium alginate-based esomeprazole hydrogels.

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Influence of the pH value and the surfactant concentration on the pumping performance of magnesium fuel based Janus micropumps

Cited by 7 publications

References 40 publications

Semishell Janus Nanoparticle-Enabled pH-Responsive Rod-Shaped Assembly for Photothermal Therapy

Semishell Janus Nanoparticle-Enabled pH-Responsive Rod-Shaped Assembly for Photothermal Therapy

Features of Anisotropic Drug Delivery Systems

Fabrication of Polymeric Hydrogels Containing Esomeprazole for Oral Delivery: In Vitro and In Vivo Pharmacokinetic Characterization

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