Relevance. In modern conditions of industrial poultry farming, technological methods in many respects do not correspond to the biological needs of the bird's body. A high concentration of poultry in limited areas, year-round stay in enclosed spaces in cages leads to negative consequences. Under the influence of unfavorable factors, nonspecific resistance and immunobiological reactivity of the organism decrease. Therefore, at present, the issues of implementing the reproductive qualities and productivity of poultry through the directed impact of biologically active substances are of particular relevance.Methods. The methodology of the work was to study the effectiveness of the use of immunostimulating drugs PS-7 and Prevention-N-C for actualization of the productive and reproductive qualities of hens of the parent flock of the Hubbard F-15 cross. The objects of research were hens of the parent flock of broilers of the French cross Hubbard F-15. In the scientific and economic experiment, according to the principle of analogue groups, three groups of birds were formed with 150 heads each: one control and two experimental groups. Chickens of the 1st experimental group at the age of 21–23 weeks were fed with water three times with an interval of 7 days the biopreparation PS-7 at a dose of 0.1 ml/kg of body weight, chickens of the 2nd experimental group — Prevention-N-C at the same dose and timing.Results. It was found that the use of tested preparations based on the polysaccharide complex of Saccharomyces cerevisiae cells and benzimedazole contributed to an earlier peak of egg production (by 2.0 and 3.0 weeks), increased egg yield on the initial laying hen (by 5.1 and 6.6%) and the average laying hen (by 2.8 and 2.0%), gross egg production (by 1,365 and 1,770 eggs) and livability (by 2.0 and 4.0%). The use of the tested preparations contributed to the improvement of the morphological parameters of eggs and, as a result, the withdrawal of chickens by 0.8 and 2.0%.