Influence of the Refinement of Surgical Technique and Surgeon’s Experience on the Rate of Complications after Total Thyroidectomy for Benign Thyroid Disease

Kotan, Çetin; Kosem, Mesut; Algün, Ekrem; Ayakta, Hayati; Sönmez, Recep Erçin; Söylemez, Ömer

doi:10.1080/00015458.2003.11679423

Cited by 11 publications

(5 citation statements)

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“…summarizes the study selection process. The characteristics of included studies are shown in Table S1 (supporting information). Of the 115 observational studies included, 61 were prospective and 55 retrospective; one study had both prospective and retrospective components.…”

Section: Resultsmentioning

confidence: 99%

Systematic review and meta-analysis of predictors of post-thyroidectomy hypocalcaemia

Edafe

Antakia

Laskar

et al. 2014

British Journal of Surgery

565

491

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Section: Resultsmentioning

confidence: 99%

Systematic review and meta-analysis of predictors of post-thyroidectomy hypocalcaemia

Edafe

Antakia

Laskar

et al. 2014

British Journal of Surgery

565

491

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“…The characteristics of the 43 selected studies are shown in Table I through Table III 8–51. Baseline characteristics are provided in Table IV.…”

Section: Resultsmentioning

confidence: 99%

Tissue factor pathway inhibitor‐2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma†

Wong

Lee

et al. 2007

Hepatology

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In HCC, inactivation of tumor suppressor genes plays a significant role in carcinogenesis. Apart from deletions and mutations, growing evidence has indicated that epigenetic alterations including aberrant promoter methylation and histone deacetylation are also implicated in inactivation of tumor suppressor genes. The goal of this study was to identify epigenetically silenced candidate tumor suppressor genes in human HCC by comparing the changes in oligonucleotide microarray gene expression profiles in HCC cell lines upon pharmacological treatment with the demethylating agent 5-Aza-2 -deoxycytidine (5-AzadC). By analyzing the gene expression profiles, we selected tissue factor pathway inhibitor-2 (TFPI-2), a Kunitz-type serine protease inhibitor, for validation and further characterization. Our results showed that TFPI-2 was frequently silenced in human HCC and HCC cell lines. TFPI-2 was significantly underexpressed in approximately 90% of primary HCCs when compared with their corresponding nontumorous livers. TFPI-2 promoter methylation was detected in 80% of HCC cell lines and 47% of human HCCs and was accompanied by reduced TFPI-2 messenger RNA expression. In addition, TFPI-2 expression in HCC cell lines can be robustly restored by combined treatment with 5-Aza-dC and histone deacetylase inhibitor trichostatin A. These findings indicate that TFPI-2 is frequently silenced in human HCC via epigenetic alterations, including promoter methylation and histone deacetylation. Moreover, ectopic overexpression of TFPI-2 significantly suppressed the proliferation and invasiveness of HCC cells. Conclusion: Our findings suggest that TFPI-2 is a candidate tumor suppressor gene in human HCC. (HEPATOLOGY 2007;45:1129-1138

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“…In most studies, laryngeal nerve function was evaluated with postoperative nasopharyngoscopy and subjective assessment of vocal fold movements. The evaluation of vocal fold movement depends on the material used (videolaryngostroboscopy) and the surgeon experience and may, therefore, report low-to-moderate interrater reliability [ 36 , 37 ]. In practice, it is recommended to assess voice quality through videolaryngostroboscopy, subjective and objective voice evaluations [ 38 ], a combination of which was performed in only a few studies [ 14 , 16 , 18 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Facelift thyroid surgery: A systematic review of indications, surgical and functional outcomes

Lechien

Fisichella

Dapri

et al. 2023

Journal of Otolaryngology - Head & Neck Surgery

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Objective To investigate indications, surgical and functional outcomes of robotic or endoscopic facelift thyroid surgery (FTS) and whether FTS reported comparable outcomes of other surgical approaches. Data sources PubMed, Cochrane Library, and Scopus. Review methods A literature search was conducted about indications, clinical and surgical outcomes of patients who underwent FTS using PICOTS and PRISMA Statements. Outcomes reviewed included age; gender; indications; pathology; functional evaluations; surgical outcomes and complications. Results Fifteen papers met our inclusion criteria, accounting for 394 patients. Endoscopic or robotic FTS was carried out for benign and malignant thyroid lesions, with or without central neck dissection. Nodule size and thyroid lobe volume did not exceed 6, 10 cm, respectively. FTS reported comparable outcome with transaxillary or oral approaches about operative time, complication rates or drainage features. The mean operative time ranged from 88 to 220 min, depending on the type of surgery (endoscopic vs robotic hemi- or total thyroidectomy). Conversion to open surgery was rare, occurring in 0–6.3% of cases. The most common complications were earlobe hypoesthesia, hematoma, seroma, transient hypocalcemia and transient recurrent nerve palsy. There was an important disparity between studies about the inclusion/exclusion criteria, surgical and functional outcomes. Conclusion FTS is a safe and effective approach for thyroid benign and malignant lesions. FTS reports similar complications to conventional thyroidectomy and excellent cosmetic satisfaction. Graphical abstract

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Influence of the Refinement of Surgical Technique and Surgeon’s Experience on the Rate of Complications after Total Thyroidectomy for Benign Thyroid Disease

Abstract: Complications of total thyroidectomy can be minimized with increasing experience and the refinement of surgical technique.

Cited by 11 publications

References 0 publications

Systematic review and meta-analysis of predictors of post-thyroidectomy hypocalcaemia

Systematic review and meta-analysis of predictors of post-thyroidectomy hypocalcaemia

Tissue factor pathway inhibitor‐2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma†

Facelift thyroid surgery: A systematic review of indications, surgical and functional outcomes

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