2006
DOI: 10.5414/cpp44648
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Influence of the retinoid acitretin on erythrocyte microrheology in vitro

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Cited by 8 publications
(5 citation statements)
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“…Gornicki and Gutsze 24 have shown that the old aromatic retinoid etretinate can increase the erythrocyte membrane fluidity and consequently the deformability of these cells, an effect opposed to the thrombogenic action reported in the present case. However, Gornicki 25 reported later that acitretin, the active derivative of etretinate, can reduce the deformability of erythrocytes. This ambiguity could be extended to isotretinoin and help to explain both the thrombotic and antithrombotic effects of the drug.…”
Section: Discussionmentioning
confidence: 99%
“…Gornicki and Gutsze 24 have shown that the old aromatic retinoid etretinate can increase the erythrocyte membrane fluidity and consequently the deformability of these cells, an effect opposed to the thrombogenic action reported in the present case. However, Gornicki 25 reported later that acitretin, the active derivative of etretinate, can reduce the deformability of erythrocytes. This ambiguity could be extended to isotretinoin and help to explain both the thrombotic and antithrombotic effects of the drug.…”
Section: Discussionmentioning
confidence: 99%
“…In the presence of retinol, erythrocyte membrane viscoelasticity and fluidity change due to an increase in cholesterol [35] and phospholipids content, as well as because of redistribution of the phospholipids within lipid bilayer [36]. These phenomena affect an erythrocytic ability to undergo a reversible deformation [37].…”
Section: Resultsmentioning
confidence: 99%
“…A characteristic feature of the change in the deformation properties of erythrocytes in the experiencing blood is the appearance of the bend on osmoscans in the area (200-210) mosmol/kg H 2 O of the suspension medium. Researchers have previously observed this phenomenon, for example, with xerocytosis and sickle cell anemia [18,19], with stomacytic elliptocytosis and ovalocytosis [20,21], red blood cell treated with increasing concentrations of lysolecithin and diamide [22], hydroxyurea [23], dinitrobenzene [24], acitretin [25]. The appearance of two hypotonic minima on osmuscans was either not given attention, either due to the presence of cell populations by different S/V ratios, or the presence of completely non-deformable cells.…”
Section: Resultsmentioning
confidence: 99%