Influence of the sequence of administration of β-glucans and a Vibrio damsela vaccine on the immune response of turbot (Scophthalmus maximus L.)

Abstract

Yeast (Saccharomyces cerevisae) beta-1,3 glucans were used as adjuvant in a Vibrio damsela vaccine for turbot (Scophthalmus maximus L.). Turbot were injected with the adjuvant prior, at the same time and after the vaccine. Several immune parameters (index and rate of phagocytosis, passive haemolytic plaque numbers, and agglutinating antibody titers) were determined at different times postinoculation. The highest activity of all the immune parameters was obtained when glucans were injected after the bacterin. It is concluded that the sequence of glucan administration is critical when used as a vaccine adjuvant.

The effect of dietary immunomodulation upon Edwardsiella tarda vaccination in healthy and immunocompromised Indian major carp (Labeo rohita)

“…As the highest activities of immunostimulants on the immune parameters may be obtained after bacterin exposure [28], glucan and levamisole were administered after bacterin exposure. Although administration of vitamins has been advocated before vaccination, they were continued up to the end of the trial.…”

“…However, some studies reveal that yeast glucan could not enhance protection against V. anguillarum in trout [23,24] and E. tarda in common carp [19]. The adjuvant e#ects of yeast glucan have also been demonstrated and can increase antibody titres against A. salmonicida in Atlantic salmon [25,26], Y. ruckeri in rainbow trout [27] and Vibrio damsela in turbot [28].…”

An Overview of the Immunological Defenses in Fish Skin

“…This is a very new area of interest with a great applicated potential in aquaculture systems. For many fish species, the immune modulation activity of beta-glucans has been reported [315], and recent preliminary research data indicates that beta-glucan promotes an antimicrobial response [316]. Furthermore, beta-glucans can potentially affect mucin structure and/or function as they interact with innate signalling pathways in mucus producing cells.…”

Effect of dietary β-1,3 glucan on immune responses and disease resistance of healthy and aflatoxin B1-induced immunocompromised rohu (Labeo rohita Hamilton)

“…Glucans, long-chain polysaccharides extracted from yeasts, are good stimulators of non-specific defence mechanisms in animals including fish (Robertsen et al, 1990;Figueras et al, 1998). In mammals, -glucan has been shown to stimulate anti-tumour mechanisms and to increase host resistance to a diverse range of microbial pathogens, and is also immunostimulatory (Di-Luzio, 1985;Seljelid et al, 1987).…”