Influence of the surface tension of wet massing liquid on the functionality of microcrystalline cellulose as pelletization aid

Quality aspects in the development of pelletized dosage forms

“…Different grades of MCC show significant difference in their physical properties, which influences the water uptake. Even though MCC grades that possess high bulk density, lower porosity and good water retentive capacity produce equivalent size pellets, these pellets are less spherical and are observed to show more shape variations [ 58 , 59 ]. MCC exhibits batch variability as it is derived from natural sources.…”

“…The most preferable processing can be done at temperature above the M.P. of semi-crystalline polymers or [ 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 ] °C above the glass transition temperature Tg of amorphous polymers, but below the M. P. of the crystalline API [ 80 , 81 ].…”