1997
DOI: 10.1016/s0168-3659(97)00061-8
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Influence of the type of surfactant on the analgesic effects induced by the peptide dalargin after its delivery across the blood–brain barrier using surfactant-coated nanoparticles

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Cited by 174 publications
(84 citation statements)
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“…Polysorbate 20,40,60 and 80 have been used to coat the surface of PBC nanoparticles (Kreuter et al, 1997;Kumari et al, 2010). Polysorbate coating leads to the alteration of surface properties of the nanoparticles.…”
Section: Polysorbatementioning
confidence: 99%
“…Polysorbate 20,40,60 and 80 have been used to coat the surface of PBC nanoparticles (Kreuter et al, 1997;Kumari et al, 2010). Polysorbate coating leads to the alteration of surface properties of the nanoparticles.…”
Section: Polysorbatementioning
confidence: 99%
“…The chemical nature of the overcoating surfactant is of importance, because only polysorbates, not poloxamers (184, 188, 388, or 407), poloxamine 908, Cremophors (EZ or RH40) or polyoxyethylene(23)-laurylether, led to a CNS pharmacological effect of dalargin. 30 As the mechanism of action, it was hypothesized that polysorbate-coated nanoparticles were transported across the BBB via endocytosis by the brain capillary endothelial cells. 29 This endocytosis would be triggered by a serum protein, apolipoprotein E, reported to adsorb on polysorbate 20, 40, 60, or 80-coated nanoparticles after a 5-min Kreuter,29 this hypothesis raises questions, based on the following observations.…”
Section: General Considerationsmentioning
confidence: 99%
“…This theory is supported by a study which reports that the coating of nanoparticles with polysorbate-80 leads to a specific alteration of the surface properties of the nanparticles. They further adsorb certain substances from the blood that, induce endocytic uptake from the blood stream by the endothelial cells of BBB [18]. The concentration of polysorbate-80 which we have used was 1% and this concentration was found to be a contributing factor for transport to brain.…”
Section: Discussionmentioning
confidence: 98%