Influence of the Vitamin D Receptor Gene Alleles on Bone Mineral Density in Postmenopausal and Osteoporotic Women

Vandevyver, Caroline; Wylin, Tine; Cassiman, Jean‐Jacques; Raus, Jef; Geusens, Piet

doi:10.1359/jbmr.1997.12.2.241

Cited by 105 publications

(70 citation statements)

References 23 publications

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“…Postmenopausal osteoporosis is a common disease associated with aging, mainly in postmenopausal eldly women, which seriously affect their health and quality of life, and even shorten life expectancy [12][13][14]. Gross et al [15] conducted a study in postmenopausal Mexican-American women, showed that FokI polymorphism of the VDR gene correlates significantly with decreased BMD at the lumbar spine and an increased rate of bone loss at the hip in ff subjects.…”

Section: Introductionmentioning

confidence: 99%

The Association between Vitamin D Receptor FokI Gene Polymorphism and Osteoporosis in Postmenopausal Women: A Meta-Analysis

Zhang

Ning

et al. 2015

J Osteopor Phys Act

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Objective: The aim of this study was to quantitatively summarize the evidence for VDR FokI gene polymorphism and osteoporosis risk in postmenopausal women. Materials and methods:Electronic search at PubMed, EMBASE, Weipu database, and Wanfang database was conducted to select studies. Case-control studies containing available genotype frequencies of F/f were chosen, and Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this revelance. Results:The case-control studies including 2199 osteoporosis cases and 2231 controls were identified. Overall meta-analysis indicated that individuals with the homozygous ff genotype had increased risk of osteoporosis(Recessive model: OR=1.551, 95% CI: 1.035~2.325,p=0.034).In the stratified analysis, individuals with the ff genotype in the Recessive model had increased risk of osteoporosis in Asian subjects(OR=2.644, 95% CI: 1.583~4.419,p= 0.000),but not in Caucasian subjects(OR= 1.288, 95%CI: 0.783~2.118, p = 0.318) and Mixed subjects (OR= 0.885, 95%CI: 0.686~1.141, p =0.346). A symmetric funnel plot, the Begg-test (P=0.094) suggested that lack of publication bias. The studies conducted in each of the defined number of osteoporosis-had no effect of the FokI polymorphism on osteoporosis except for the ff versus Ff+FF genotype comparison for osteoporosis subgroup. Conclusion:In conclusion, our meta-analysis suggests that VDR Fok I genotype is associated with increased risk of osteoporosis in Asian but not in caucasian. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VDR Fok I polymorphism and osteoporosis.

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Section: Introductionmentioning

confidence: 99%

The Association between Vitamin D Receptor FokI Gene Polymorphism and Osteoporosis in Postmenopausal Women: A Meta-Analysis

Zhang

Ning

et al. 2015

J Osteopor Phys Act

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“…According to our inclusion criteria, a total of 11 eligible studies involving 1468 cases and 2177 controls were included in the pooled analysis (Berg et al, 1996;Vandevyver et al, 1997;Gomez et al, 1999;Valimaki et al, 2001;Zajickova et al, 2002;Douroudis et al, 2003;Zhu et al, 2004;Garnero et al, 2005;Horst-Sikorska et al, 2005;Mitra et al, 2006;Ge et al, 2009). The characteristics of selected studies are summarized in Figure 1.…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

Association of vitamin D receptor BsmI gene polymorphism with risk of low bone mineral density in post-menopausal women: a meta-analysis

Ma¹,

Zhou²,

Deng³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. The vitamin D receptor BsmI gene polymorphism is reportedly associated with low bone mineral density (BMD) in postmenopausal women, but results from previous studies are conflicting. In the present study, we investigated the association between this polymorphism and the risk of low BMD through a metaanalysis of published studies. A literature search of the Pubmed, Embase, and CNKI databases from inception through July 2013 was conducted. The meta-analysis was performed using the STATA 12.0 software. Crude odds ratios with 95% confidence intervals were used to assess the strength of any association. Eleven case-control studies were included for a total of 1468 low BMD cases and 2177 healthy controls. No significant variation in low BMD risk was detected in any of the genetic models. Further stratified analyses were performed to examine the effect of ethnicity. In the subgroup analysis, no significant association was found in Caucasians and in Asians. The meta-analysis results suggest that the BsmI polymorphism is not associated with low BMD risk in postmenopausal women.

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“…Several studies in Caucasian and Asian populations (Yamagata et al 1994;Fleet et al 1995;Koshiyama et al 1995;Riggs et al 1995;Gross et al 1996;Momson et al 1997;Tamai et al 1997) have shown an allelic effect between extreme homozygotes of perhaps 0.5 SD units, with a difference in bone density ranging from 4 to 13 %. Other studies have reported little or no effect in various Caucasian populations (Hustmyer et Barger-Lux et al 1995a, b;Garnero et al 1995;Keen et al 1995;Kroger et al 1995;Jorgensen et al 1996;Alahari et al 1997;Francis et al 1997;Gunnes et al 1997;McClure et al 1997;Vandevyver et al 1997). Moreover, three studies, including a large Dutch study, have reported a VDR gene allele effect but in the opposite direction to that of the previous studies (Houston et al 1996;Uitterlinden et al 1996;Salamone et al 1996).…”

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confidence: 95%

“…Also, VDR genotype has been related to body size at various stages of life from infancy onwards (BargerLux et al 1995a, b;Keen et al 1997;Tamai et al 1997). Furthermore, in one study of femoral-neck bone density a VDR allele effect was noted in average-weight subjects but not in obese subjects (BMI >30kg/m2;Vandevyver et al 1997). These interactions with body and bone size will need to be carefully elucidated before the potential for interaction between genetic factors and nutritional intake can be fully understood.…”

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confidence: 99%

Genetics, calcium intake and osteoporosis

Eisman

1998

Proc. Nutr. Soc.

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Osteoporosis is a major health problem worldwide, particularly with advancing age in both men and women. The strength of the skeleton in older age results from bone strength achieved in early adulthood and age-related and, in women, post-menopause-related bone loss. While trauma and the manner in which older people fall are important contributors to fracture risk, low bone mass is a major factor. Determinants of bone mass include external factors such as lifestyle, especially physical activity, and calcium intake. The wide variation in dietary calcium intake across countries does not correlate with osteoporotic fracture risk, presumably due to ethnic differences between and within populations. The twin approach has been useful in the identification of the major part of age-specific variation in bone density (and turnover), which is genetically determined. Exploring possible genetic factors, we reported that common allelic variations in the vitamin D receptor (VDR) gene were associated with indices of bone turnover and density. Subsequent studies, including our own, have found weaker effects. However, allelic effects of the VDR gene polymorphisms have now been reported in a wide range of, but not all, Caucasian and Asian populations in which they have been studied. In relation to possible physiological mechanisms, the VDR alleles correlate with differences in gut calcium absorption and response of bone density to long-term dietary calcium intake. Moreover, differences in response to active vitamin D compounds have been found in relation to VDR gene alleles. Understanding how these allelic variants, which are not associated with differences in

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Influence of the Vitamin D Receptor Gene Alleles on Bone Mineral Density in Postmenopausal and Osteoporotic Women

Cited by 105 publications

References 23 publications

The Association between Vitamin D Receptor FokI Gene Polymorphism and Osteoporosis in Postmenopausal Women: A Meta-Analysis

The Association between Vitamin D Receptor FokI Gene Polymorphism and Osteoporosis in Postmenopausal Women: A Meta-Analysis

Association of vitamin D receptor BsmI gene polymorphism with risk of low bone mineral density in post-menopausal women: a meta-analysis

Genetics, calcium intake and osteoporosis

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