Influence of Thermal Drive on Central Sleep Apnea in the Preterm Neonate

Tourneux, P.; Cardot, V.; Museux, Nathanaëlle; Chardon, Karen; Léké, A.; Telliez, Frédéric; Libert, Jean‐Pierre; Bach, Véronique

doi:10.1093/sleep/31.4.549

Cited by 32 publications

(30 citation statements)

References 44 publications

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“…Temperature values on the lower limits of the range seem to be associated with lower apnea rates, 47 so overheating should be avoided, even if more studies are needed to confirm this observation. …”

Section: Environmental Temperaturementioning

confidence: 95%

Apnea of prematurity: challenges and solutions

Picone¹,

Aufieri²,

Paolillo³

2014

RRN

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Apnea of prematurity is a developmental disorder that frequently affects preterm infants, especially those with lower gestational age. Even if apnea of prematurity is by definition a self-limiting condition, it can cause serious problems during the hospital stay and can potentially have long-term neurological and cognitive consequences depending on the severity and intensity of the episodes. The diagnosis of apnea of prematurity can be made only after excluding a number of diseases of the preterm infant in which apnea may be an epiphenomenon. Etiological diagnosis is essential for selection of appropriate treatment, which may be nonpharmacological or involve use of drugs.

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Section: Environmental Temperaturementioning

confidence: 95%

Apnea of prematurity: challenges and solutions

Picone¹,

Aufieri²,

Paolillo³

2014

RRN

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“…In a recent study, less apnea was found at an incubator temperature of 30.4°C than at 32.5°C [91]. Of course, a number of factors play a role in incubator and baby temperature, but overheating may be a factor in AOP.…”

Section: Interventions For Premature Infants With Apneamentioning

confidence: 99%

Apnea of prematurity: from cause to treatment

2011

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Apnea of prematurity (AOP) is a common problem affecting premature infants, likely secondary to a “physiologic” immaturity of respiratory control that may be exacerbated by neonatal disease. These include altered ventilatory responses to hypoxia, hypercapnia, and altered sleep states, while the roles of gastroesophageal reflux and anemia remain controversial. Standard clinical management of the obstructive subtype of AOP includes prone positioning and continuous positive or nasal intermittent positive pressure ventilation to prevent pharyngeal collapse and alveolar atelectasis, while methylxanthine therapy is a mainstay of treatment of central apnea by stimulating the central nervous system and respiratory muscle function. Other therapies, including kangaroo care, red blood cell transfusions, and CO2 inhalation, require further study. The physiology and pathophysiology behind AOP are discussed, including the laryngeal chemoreflex and sensitivity to inhibitory neurotransmitters, as are the mechanisms by which different therapies may work and the potential long-term neurodevelopmental consequences of AOP and its treatment.

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“…Sleep apnoeas were scored only if they lasted 3 s or more, the duration usually used at this age (Gould et al. , 1977; Tourneux et al. , 2008).…”

Section: Methodsmentioning

confidence: 99%

Decreased spontaneous arousability in preterm newborns with impaired neurological outcome

Thiriez¹,

Tournoud²,

Wermenbol³

et al. 2012

Journal of Sleep Research

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Summary Preterm newborns are at high risk of neurological injury. In this population, we investigated the link between neurological complications and sleep architecture. At term‐corrected gestational age, we studied retrospectively the polysomnography of 45 preterm infants born at < 28 weeks or weighting < 1 kg. These infants were followed‐up by a neuropaediatrician (median age at last follow‐up 50.4 months). Two groups of children were constituted: a group without neurological disorder and a second group with at least one of the following: cerebral palsy, language or mental retardation, visual or hearing disability or attention disorder. A Multiple Indicators and Multiple Causes model assessed the relationship between the neurological outcome and two sleep components: spontaneous arousability [number of awakenings and movements per hour of quiet sleep (QS) and active sleep] and QS characteristics (median duration of QS cycles and percentage of QS over total sleep time). Twenty‐six infants had an impaired neurological outcome. There were no statistical differences between the two groups regarding clinical characteristics. Compared to preterm neonates with normal neurological outcome, those with impaired outcomes had a lower spontaneous arousability; i.e. 0.7 (0.5–1) times less awakenings and movements per hour of QS and 0.9 (0.8–1) times less per hour of active sleep than infants with normal outcomes (P = 0.05). The differences in QS characteristics did not reach statistical significance. These findings suggested that, in preterm infants, perinatal neurological injuries could be associated with an abnormal sleep architecture characterized by altered spontaneous arousability.

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Influence of Thermal Drive on Central Sleep Apnea in the Preterm Neonate

Cited by 32 publications

References 44 publications

Apnea of prematurity: challenges and solutions

Apnea of prematurity: challenges and solutions

Apnea of prematurity: from cause to treatment

Decreased spontaneous arousability in preterm newborns with impaired neurological outcome

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