Influence of thickness, homogeneity, and morphology of TiO2-m nanoparticle coatings on cancer cell adhesion

Diosa, Jaime Andres Garcia; Gonzalez-Orive, Alejandro; Grundmeier, Guido; Keller, Adrian; Camargo-Amado, Rubén J.

doi:10.1016/j.surfcoat.2021.127823

Cited by 7 publications

(5 citation statements)

References 47 publications

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“…[ 33 , 34 ] Here we consider that the slight decrease of biocompatibility may be due to TiO 2 . [ 35 , 36 , 37 ] Cytoskeleton and adult neuron marker stainings were performed on day 14 of culture to check long‐term cell characteristics and morphology changes. Cells were fixed after 3‐day and 14‐day cultures and stained with NeuN and f‐actin filaments to visualize nucleus, cytoskeletal, and network connections.…”

Section: Resultsmentioning

confidence: 99%

A Retina‐Inspired Optoelectronic Synapse Using Quantum Dots for Neuromorphic Photostimulation of Neurons

Balamur,

Eren,

Kaleli

et al. 2024

Advanced Science

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Neuromorphic electronics, inspired by the functions of neurons, have the potential to enable biomimetic communication with cells. Such systems require operation in aqueous environments, generation of sufficient levels of ionic currents for neurostimulation, and plasticity. However, their implementation requires a combination of separate devices, such as sensors, organic synaptic transistors, and stimulation electrodes. Here, a compact neuromorphic synapse that combines photodetection, memory, and neurostimulation functionalities all‐in‐one is presented. The artificial photoreception is facilitated by a photovoltaic device based on cell‐interfacing InP/ZnS quantum dots, which induces photo‐faradaic charge‐transfer mediated plasticity. The device sends excitatory post‐synaptic currents exhibiting paired‐pulse facilitation and post‐tetanic potentiation to the hippocampal neurons via the biohybrid synapse. The electrophysiological recordings indicate modulation of the probability of action potential firing due to biomimetic temporal summation of excitatory post‐synaptic currents. The results pave the way for the development of novel bioinspired neuroprosthetics and soft robotics and highlight the potential of quantum dots for achieving versatile neuromorphic functionality in aqueous environments.

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Section: Resultsmentioning

confidence: 99%

A Retina‐Inspired Optoelectronic Synapse Using Quantum Dots for Neuromorphic Photostimulation of Neurons

Balamur,

Eren,

Kaleli

et al. 2024

Advanced Science

View full text Add to dashboard Cite

show abstract

“…[ 33 , 34 ] Here we consider that the slight decrease of biocompatibility may be due to TiO 2 . [ 35 , 36 , 37 ] Cytoskeleton and adult neuron marker stainings were performed on day 14 of culture to check long‐term cell characteristics and morphology changes. Cells were fixed after 3‐ and 14‐day cultures and stained with NeuN and f‐actin filaments to visualize nucleus, cytoskeletal, and network connections.…”

Section: Resultsmentioning

confidence: 99%

A Retina‐Inspired Optoelectronic Synapse Using Quantum Dots for Neuromorphic Photostimulation of Neurons

Balamur,

Eren,

Kaleli

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Neuromorphic electronics, inspired by the functions of neurons, have the potential to enable biomimetic communication with cells. Such systems require operation in aqueous environments, generation of sufficient levels of ionic currents for neurostimulation, and plasticity. However, their implementation requires a combination of separate devices, such as sensors, organic synaptic transistors, and stimulation electrodes. Here, a compact neuromorphic synapse that combines photodetection, memory, and neurostimulation functionalities all‐in‐one is presented. The artificial photoreception is facilitated by a photovoltaic device based on cell‐interfacing InP/ZnS quantum dots, which induces photo‐faradaic charge‐transfer mediated plasticity. The device sends excitatory post‐synaptic currents exhibiting paired‐pulse facilitation and post‐tetanic potentiation to the hippocampal neurons via the biohybrid synapse. The electrophysiological recordings indicate modulation of the probability of action potential firing due to biomimetic temporal summation of excitatory post‐synaptic currents. These results pave the way for the development of novel bioinspired neuroprosthetics and soft robotics, and highlight the potential of quantum dots for achieving versatile neuromorphic functionality in aqueous environments.

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“…The elongated shape of Ag@TiO 2 NRs on GG hydrogel film improved cell adhesion, which aided cell proliferation [48,49]. Researchers have widely reported TiO 2 's beneficial effect on cellular functions such as cell adhesion and proliferation [50,51]. In addition, it is commonly known that TiO 2 nanomaterials, including TiO 2 nanorods, are biologically inert and nontoxic to both human and animal cells [52,53].…”

Section: Resultsmentioning

confidence: 99%

In-vitro and in-vivo wound healing studies of Ag@TiO₂NRs/GG hydrogel film for skin tissue regeneration

Tan²,

Zhao

et al. 2023

Mater. Res. Express

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One million cases of skin wounds, either closed or open wounds, necessitate wound treatments to improve the quality of life. In this study, gellan gum biopolymer (Ag@TiO2NRs/GG) hydrogel film with Ag loaded TiO2 nanorods was fabricated for wound healing dressing. The wound healing performance of Ag@TiO2WR/GG hydrogel was tested in vitro and in vivo to investigate its ability to regenerate skin tissue. FTIR, XRD, and SEM were used to examine the physical and chemical properties of prepared Ag@TiO2NRs/GG hydrogel film, as well as pure Ag and Ag@TiO2NRs. The FTIR spectra revealed the functional groups of Ag, TiO2NRs, GG, and their interactions. The hydrogel film was in an amorphous form, according to XRD analysis, due to the helical structure of GG and the presence of Ag and TiO2NRs in distinct phases The SEM image shows agglomeration of Ag particles and elongated TiO2 nanorods, indicating that Ag@TiO2NRs were successfully incorporated onto GG hydrogel film. Human skin fibroblast cells (CRL2522) were used to study the in vitro wound healing of Ag@TiO2NRs/GG hydrogel film for cell viability and proliferation. After 72 h, ~98,022 cells/well were counted, indicating that the Ag@TiO2NRs/GG was biocompatible and non-toxic. In vivo wound healing on Sprague Dawley rats revealed 100% wound healing after 14 days of treatment with Ag@TiO2NRs/GG hydrogel film. On a treated skin wound, ultrasound images revealed a thicker epidermis, clear dermis, and subcutis layer, indicating a positive correlation between wound healing and skin tissue regeneration.

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Influence of thickness, homogeneity, and morphology of TiO2-m nanoparticle coatings on cancer cell adhesion

Cited by 7 publications

References 47 publications

A Retina‐Inspired Optoelectronic Synapse Using Quantum Dots for Neuromorphic Photostimulation of Neurons

A Retina‐Inspired Optoelectronic Synapse Using Quantum Dots for Neuromorphic Photostimulation of Neurons

A Retina‐Inspired Optoelectronic Synapse Using Quantum Dots for Neuromorphic Photostimulation of Neurons

In-vitro and in-vivo wound healing studies of Ag@TiO₂NRs/GG hydrogel film for skin tissue regeneration

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Influence of thickness, homogeneity, and morphology of TiO2-m nanoparticle coatings on cancer cell adhesion

Cited by 7 publications

References 47 publications

A Retina‐Inspired Optoelectronic Synapse Using Quantum Dots for Neuromorphic Photostimulation of Neurons

A Retina‐Inspired Optoelectronic Synapse Using Quantum Dots for Neuromorphic Photostimulation of Neurons

A Retina‐Inspired Optoelectronic Synapse Using Quantum Dots for Neuromorphic Photostimulation of Neurons

In-vitro and in-vivo wound healing studies of Ag@TiO2NRs/GG hydrogel film for skin tissue regeneration

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Product

Resources

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In-vitro and in-vivo wound healing studies of Ag@TiO₂NRs/GG hydrogel film for skin tissue regeneration