Influence of “Thireomagnile” and “Thyrioton” preparations on the antioxidant status of pregnant cows with symptoms of endotoxicosis

Grymak, Y.; Skoromna, O.; Stadnytska, O. I.; Sobolev, O. I.; Gutyj, B. V.; Shalovylo, S. H.; Hachak, Yuriy; Grabovska, O. S.; Бушуєва, Інна Володимирівна; Denys, Gerald A.; Hudyma, V.; Pakholkiv, N.; Jarochovich, I.; Nahirniak, T.; Pavliv, Oleksandra; Фарионик, Т В; Bratyuk, V.

doi:10.15421/2020_19

Cited by 34 publications

(31 citation statements)

References 14 publications

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“…Today a considerable number of reports is dedicated to the role of lipid peroxidation in the development of many diseases of noninfectious and infectious etiology (encephalomalacia and exudative chicken diathesis, white muscle disease, gastrointestinal, respiratory and metabolic diseases, in particular microelementosis, kidney and liver damage, endometri-tis, mastitis etc.) (Gutyj et al, 2019;Grymak et al, 2020). However, there has been insufficient research on the role of lipid peroxidation in cattle from the areas under the technogenic pollution.…”

Section: Discussionmentioning

confidence: 99%

Effect of zinc nanoaquacitrate on the biochemical and productive parameters of the organism of rabbits

Бойко¹,

Honchar²,

Lesyk

et al. 2020

Regul. Mech. Biosyst.

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Zinc is an essential microelement for the organism of animals, and its deficiency reduces the synthesis and degradation of proteins, lipids, carbohydrates and nucleic acids, and also decreases the metabolism of vital microelements. The objective of the study was determining the effect of various amounts of zinc nanoaquacitrate on the biochemical parameters of blood and productivity of the organism of rabbits after weaning on 50th to 86th days of life. Compared with the control group, intake of zinc nanoaquacitrate by the animals of the experimental groups exhibited dose-dependent effect on separate biochemical parameters which characterize the processes of lipid and mineral metabolisms, which manifested in the increase in their content in the blood on the 12th, 24th and 36th days of the experiment. Watering rabbits with zinc citrate in the dose of Zn 0.25 mg/kg after weaning determined its physiological effect on the biochemical parameters of their organism, expressed in the most statistically reliable changes compared with other tested amounts, particularly a higher level of the total protein, increase in the activities of glutathione reductase, alanine aminotransferase, catalase and alkaline phosphatase and decrease in the levels of cholesterol, lipid hydroperoxides, compared with the control, which may indicate the positive effect of the applied additives on certain biochemical parameters of the rabbits’ organism. Additional use of zinc citrate in the dose of 0.50 mg/kg of body weight was manifested in their blood by significant increase in the activities of catalase and glutathione reductase, lower level of lipid hydroperoxides and increase in the organism’s growth parameter by 3.1% in the final period of the study. Watering zinc citrate in the amount of 0.75 mg/kg of body weight provoked probable decrease in the level of cholesterol and triacylglycerols and increases in catalase and glutathione reductase, increase in activity of alanine aminotrasferase and decrease in lipid hydroperoxides, which determined the stimulating effect on the growth of the organism with 8.4% higher total gain of body weight after 36 days of the experiment. From a general perspective, the research indicates that intake of lowest amount of zinc citrate was characterized by the greatest effect on the biochemical blood parameters, whereas the use of greater amounts of organic compound of zinc showed positive effect on the processes of growth and development of the organism of rabbits after weaning. Of practical importance is the study of the effect of watering zinc nanoaquacitrate in the physiologically substantiated amounts on biochemical blood parameters and growth and survivability of the offspring and organism of the mother rabbit in the period of lactation.

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Section: Discussionmentioning

confidence: 99%

Effect of zinc nanoaquacitrate on the biochemical and productive parameters of the organism of rabbits

Бойко¹,

Honchar²,

Lesyk

et al. 2020

Regul. Mech. Biosyst.

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“…Therefore, during peroxidation of lipids with active forms of oxygen, other active radicals form (peroxides, epoxides, aldehydes, ketons, alcohols, dialdehydes) which can covalently interact with separately functional groups of proteins, leading to destruction of their amino acid residues (Boyko et al, 2016;Kisera et al, 2019). All this may cause modification of the phospholipid bilayer of cellular markers, particularly emergence of oxidation products in the hydrophobic region, which initiate the processes of ionic transport, change in the conformational isomerism of protein and lipid composition, and from there the structural and functional properties of membranes (Kulyaba et al, 2019;Grymak et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Association of BoLA-DRB3.2 alleles with fusobacteriosis in cows

Suprovych

Kolinchuk

et al. 2020

Regul. Mech. Biosyst.

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The Major Histocompatability Complex (MHC) determines the immune response to pathogens, and its genes are promising candidates for the search of associations with diseases. A special role is played by BoLA-DRB3 gene, the product of which directly participates in the binding of alien antigens and conditions the specificity of the immune response. The second exon of this gene codes β1-domain of class II antigens, which is necessary for binding a broad spectrum of alien antigens. Exon 2 of BoLA-DRB3 gene is extremely polymorphic, giving the possibility to search the associations of its alleles with various diseases. The article provides the results of the study on polymorphism of alleles of BoLA-DRB3.2 gene for detection of its associations with sensitivity to fusobacteriosis (necrobacteriosis) of cows. The survey was performed using PCR-RFLP method with DNA of blood from 176 cows of two herds of Ukrainian black-and-white dairy breed. As a result of the studies, in the first herd, 25 BoLA-DRB3.2 alleles were found. In the selections of nectobacteriosis susceptible and resistant cows, we found 22 and 21 variants respectively. In the second herd, in the general selection and group of healthy animals, 27 alleles were typed, and 22 in the group of susceptible cows. BoLA-DRB3.2*22 allele was the commonest in both herds in both general selections and groups of nectobacteriosis-resistant cows. In the selection of susceptible animals, the commonest was the variant BoLA-DRB3.2*16. We determined statistically significant associations of BoLA-DRB3.2 alleles with sensitivity to nectobacteriosis of cattle. BoLA-DRB3.2*03 and *22 alleles associate with nectobacteriosis-resistant, while *16 and *23 – with nectobacteriosis-susceptible cows of the both studied groups. Also, in the first herd, another allele was found – *24, indicating close relationship with the disease. The studies of polymorphism of BoLA-DRB3 gene expand the knowledge about genetic peculiarities of the Ukrainian black-and-white dairy breed. The identified molecular-genetic markers could be useful for breeders whose work is oriented towards the formation of herds which are resistant to diseases of the limbs in cattle.

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“…ВРО є процесом безпосереднього переносу кисню на субстрат з утворенням перекисів, кетонів, альдегідів, причому ці реакції є ланцюговими. До процесів пероксидного окиснення схильні деякі амінокислоти, білки, вода, вуглеводи, але в організмі вирішальне значення мають ліпіди за рахунок ненасичених жирних кислот (НЖК), що входять до їх складу (Min & Boff, 2006;Valko et al, 2007;Grymak et al, 2020;Slobodian & Hutyi, 2020).…”

Section: вступunclassified

Correction of the state of antioxidant protection system of the fowl’s organism under the circumstances of being poisoned by Derosal

Kochevenko¹,

Zhukova²,

Bobrytska³

et al. 2020

SMLNUVMB

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In fact, Free radical oxidation is one of the required factors of homeostasis as far as the active forms of oxygen, which have unpaired electron, perform useful functions, they are necessary intermediaries of numerous processes of normal cells’ functioning such as biosynthesis of prostaglandins and leukotriene as well as other biologically active substances. Also, they take part in pathological processes such as: inflammation, fever and others. Free radical oxidation is the process of direct oxygen transferring to the substrate forming peroxide, ketones, aldehydes, etc. Some amino acids, proteins, water and carbohydrates prone to the processes of peroxidation, but crucial place is granted to lipids at the expanse of fatty acids which are included to their composition. The article highlights the information concerning the analysis of the state of antioxidant system of hens in the process of feeding them with subtoxic doses of fungicide of Derosal (BAYER, Germany) (0.1 LD50 for a fowl, 900 mg/kg of the body mass) which active ingredient is benzimidazole carbamate (carbendazim, BMC). It presents the changes of these indicators in the process of using pharmacological and natural antioxidants. The analysis has figured out that giving Derosal to the hens without corrections (II group) has been followed with the activation of the process of lipids’ peroxidation (POL) in the blood plasma, that is followed with the increase of concentration of primary and secondary lipoperoxidation products – diene conjugates (DC) and TBA-active products on the average up to 21.0–25.0 %, catalase activity – up to 38.5 % and decrease of superoxide dismutase activity (SOD) up to 21.8 % and АОА – up to 17.8 %, that shows the adverse effects of pesticides on the system of antioxidant protection of the organism. In the fowls’ groups III, IV and V the adding of antioxidant E-selenium, ascorbic acid and thermally untreated buckwheat seeds as the source of quercetins and anthocyanins has led to the induction of antioxidant resources that is shown by the decrease in comparison with the control of content of diene conjugates, malonic dialdehyde and catalase (in average up to 13.6–33.6–18.0 % accordingly) and compensatory strengthening of superoxide dismutase activity and general activity of antioxidant (АОА) on the average up to 44.9–72.1–76.5 % and 15.3–13.4–21.7 % accordingly. In comparison with group II the activity of catalase has been lower as well as the activity of superoxide dismutase has been higher in all the groups almost in 1.5–2 times (Р ≤ 0.001).

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Influence of “Thireomagnile” and “Thyrioton” preparations on the antioxidant status of pregnant cows with symptoms of endotoxicosis

Cited by 34 publications

References 14 publications

Effect of zinc nanoaquacitrate on the biochemical and productive parameters of the organism of rabbits

Effect of zinc nanoaquacitrate on the biochemical and productive parameters of the organism of rabbits

Association of BoLA-DRB3.2 alleles with fusobacteriosis in cows

Correction of the state of antioxidant protection system of the fowl’s organism under the circumstances of being poisoned by Derosal

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