Influence of TNF-α and ESR1 Polymorphisms on Vascular, Hormonal and Inflammatory Biomarkers in Migraine

Shaik, Munvar Miya; Abubakar, Murtala Bello; Tan, Huay Lin; Gan, Siew Hua

doi:10.3923/jms.2018.76.86

Cited by 4 publications

(1 citation statement)

References 45 publications

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“… 43 In addition, polymorphisms in the ESR gene were found to be significant in female migraine patients, supporting these findings. 44 Genetic susceptibility to migraine is accepted, but there is no definitive framework. Among the molecules currently under investigation, miRNAs have significant potential.…”

Section: Discussionmentioning

confidence: 99%

The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p, and 15q13.3 hotspot CNVs in migraineurs

et al. 2023

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Subunit (CHRNA7) gene, and expression of gene-targeting miRNAs (hsa-miR-548e-5p and hsa-miR-3158-5p) in migraineurs (n = 102; with aura, n = 43; without aura, n = 59) and non-migraines (n =120) aged 15-60 years, comparative, case-control study was conducted. Genetic markers were compared with biochemical parameters (BMI, WBC, Urea, GFR, ESR, CRP, HBG). All analyzes were performed by quantitative Real-Time PCR (q-PCR) and fold change was calculated with the 2-ΔΔCT method. The diagnostic power of the CHRNA7 gene, CNV, and miRNAs were analyzed with the receiver operating curve (ROC). CHRNA7 gene and hsa-miR-3158-5p are down-regulated in migraineurs and the gene is controlled by this miRNA via CNVs (p<0.05). Both deletion and duplication were detected in patients with migraine for CVN numbers (P = 0.05). The number of CNV deletions was higher than duplications. When CHRNA7-CNV-hsa-miR-3158-5p was modeled together in the ROC analysis, the area under the curve (AUC) was 0.805, and the diagnostic power was "good". In migraineurs, the CHRNA7 gene can be controlled by hsa-miR-3158-5p via CNVs to modulate the mechanism of pain. These three genetic markers have diagnostic potential and may be used in antimigraine treatments.

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Section: Discussionmentioning

confidence: 99%

The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p, and 15q13.3 hotspot CNVs in migraineurs

et al. 2023

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Polymorphisms of Estrogen receptor alpha (ESR1) rs9340799, rs2234693, rs1801132, and rs2228480 and their association with migraine risk: a meta-analysis with meta-regression and trial sequential analysis

Sudershan,

Sheikh,

Wani

et al. 2024

Nucleus

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Role of TNF-α in the Pathogenesis of Migraine

Sudershan,

Sharma

et al. 2024

Pain Research and Management

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Background. Neurogenic neuroinflammation has a wide role in migraine pathogenesis including the transition from episodic migraine to chronic one. The seed molecule of neurogenic neuroinflammation, i.e., the TNF-α proinflammatory molecule, has gathered a lot of attention. This pleiotropic cytokine is a classical component of inflammatory soup, secreted by the microglial cell, and promotes a wide range of inflammatory reactions. Aim. In this review, we aimed to provide a culminating and comprehending glimpse into the TNF-α in association with the migraine. Method. A systematic literature survey method with a mixture of keywords was utilized to grasp the different elements that represent the association between TNF-α and migraine. Discussion. Highlighted the probable involvement of the TNF-α with migraine, the complexity of the matter such as activation of NF-KB signaling cascade, autoactivation, sensitization, and increased likelihood of transition cannot be neglected. Being TNF-α as a core node, it becomes the factor for linking diseases such as chronic inflammatory disorders, including COVID-19, and also interaction with other genes to develop severe conditions. Conclusion. To this end, TNF-α plays a critical role in chronification, and inhibiting its signaling would likely be a crucial strategy for migraine therapy.

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Influence of TNF-α and ESR1 Polymorphisms on Vascular, Hormonal and Inflammatory Biomarkers in Migraine

Cited by 4 publications

References 45 publications

The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p, and 15q13.3 hotspot CNVs in migraineurs

The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p, and 15q13.3 hotspot CNVs in migraineurs

Polymorphisms of Estrogen receptor alpha (ESR1) rs9340799, rs2234693, rs1801132, and rs2228480 and their association with migraine risk: a meta-analysis with meta-regression and trial sequential analysis

Role of TNF-α in the Pathogenesis of Migraine

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