Influence of tranexamic acid on postoperative autologous blood retransfusion in primary total hip and knee arthroplasty: a randomized controlled trial

Abstract

Addition of TXA to a restrictive transfusion protocol makes the use of a postoperative blood salvage system in patients undergoing primary hip and knee arthroplasty unnecessary.

Effect of a single injection of tranexamic acid on blood loss after primary hybrid TKA

“…This between-group difference in the proportion of patients that required autotransfusion suggests that a single injection of TXA may reduce the need for a postoperative autotransfusion system. The results of another recent paper [36], which evaluated the need for postoperative autologous blood retransfusion in primary knee and hip arthroplasty, also support this conclusion. In that study, fewer patients received autologous blood reinfusion in the TXA group (5/49) compared to the placebo group (42/49).…”

One step closer to sparing total blood loss and transfusion rate in total knee arthroplasty: a meta-analysis of different methods of tranexamic acid administration

“…Out of the 31 studies (Table 2), two were triple-blind [22,23], 20 were double-blind [8,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42], three were single-blind [43][44][45], one study was non-blinded [46], and the blinding was unclear in five of the studies [47][48][49][50][51]. In one study, the randomization was performed by a person/ pharmacist/resident who was not involved in the study or the care of patients [35].…”

What Is the Benefit of Tranexamic Acid vs Reinfusion Drains in Total Joint Arthroplasty?

“…No significant difference in deep-vein thrombosis, and pulmonary embolism was detected between the TA group and the placebo group.A few studies compare the effect of TA on reinfusion drains (amount of autologous blood reinfused) but to our knowledge no studies exist that directly compare the efficacy and reinfusion drains versus TA in THA and TKA in a prospective randomized fashion. In 2014, Oremus et al randomized patients with reinfusion drains to either receive intravenous TA or placebo (saline) to evaluate the influence of TA on the amount of transfused autologous blood[25].They determined that the addition of TA significantly reduced the amount of autologous reinfusion compared to placebo. There was no difference on allogenic transfusions between groups.…”