Mechanochemical processing of bulk solids has developed in the last three decades into a powerful and popular tool for the green synthesis and transformation of various classes of materials. Due to its efficiency and unique reactivity, mechanochemistry is becoming an integral part of synthetic laboratories and industrial procedures. However, despite its increasing popularity and usefulness, mechanochemistry is primarily based on simple techniques like grinding by hand -where the outcome often depends on the consistency and strength of the experimentalist -or milling in comminution devices, where a certain level of control is achieved through defining the frequency of milling and the weight of the milling media. Recently, however, mechanochemical reactivity started being complemented and altered by other energy sources commonly used in solution-based chemistry. Milling under controlled temperature, or photo-, sono-, and electro impulses in newly developed experimental setups has led to reactions not achievable by conventional mechanochemical processing. This Perspective describes the new reactivity discovered through these combinations of energy inputs, as well as the advances in equipment tailored to synthetic mechanochemistry that enabled them. We propose that these techniqueshere termed thermomechanochemistry, sono-mechanochemistry, electro-mechanochemistry, and photomechanochemistryrepresent a significant advance in modern mechanochemistry and herald a new level of solid-state reactivity: Mechanochemistry 2.0.