Influence of varying estrogen levels on trigeminal CGRP release in healthy women

Ibrahimi, Khatera; Danser, A.H. Jan; Cm, Villalón; Meiracker, AH van den; MaassenVanDenBrink, Antoinette

doi:10.1186/1129-2377-14-s1-p123

Cited by 7 publications

(3 citation statements)

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“…PG can cause neurogenic inflammation by promoting the release of CGRP neuropeptides substance P and neurokinins, thereby increasing the susceptibility of blood vessels to PG, which has been implicated in neurogenic inflammation [24,25]. Furthermore, changes in estrogen concentration during menstruation influences the sensitivity of the transient receptor potential vanilloid antagonist (TRPV1) receptors, therefore increasing the amount of CGRP in the terminals of perivascular nerves [26].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, changes in estrogen concentration during menstruation influences the sensitivity of the transient receptor potential vanilloid antagonist (TRPV1) receptors, therefore increasing the amount of CGRP in the terminals of perivascular nerves [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…Altogether, these findings suggest that estrogen fluctuations are involved in migraine attacks worsening during the perimenstrual window through several mechanisms directly or indirectly involving the CGRP pathway [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness and Safety of CGRP-mAbs in Menstrual-Related Migraine: A Real-World Experience

et al. 2021

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Introduction: Migraine shows a significantly higher prevalence in women, especially during reproductive age when menstrual-related hormonal fluctuations represent the most common migraine trigger. Indeed, over 50% of patients report a higher occurrence of migraine attacks during the perimenstrual window. Menstrual migraine attacks are consistently referred to as more disabling, less responsive to symptomatic treatments, longer in duration, and more prone to relapse than non-menstrual migraine attacks. Evidence strongly suggests that estrogen fluctuations are involved in migraine attacks worsening during the perimenstrual window through several mechanisms directly or indirectly involving the CGRP pathway. We aimed to evaluate whether mAbs blocking CGRP-

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%