Postmenopausal osteoporosis is associated with the regulation of SP, CGRP, VIP, and NPY

Liu, Xiaoguang; Liu, Hengrui; Xiong, Yingquan; Yang, Li; Wang, Chaopeng; Zhang, Ronghua; Zhu, Xiaofeng

doi:10.1016/j.biopha.2018.04.044

Cited by 68 publications

(44 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A large number of neuropeptides regulating bone metabolism may represent a regulatory pathway for the pathogenesis of osteoporosis. Liu et al (44) reported that after constructing a model of osteoporosis in adult female rats, ovariectomy (OVX) reduced SP in the bone. Liu et al (45) indicated that epimedium treatment reduced the effects of osteoporosis through a brain/spinal cord/bone axis by increasing bone SP.…”

Section: Osteoporosismentioning

confidence: 99%

The Role of Substance P in the Regulation of Bone and Cartilage Metabolic Activity

Lin

et al. 2020

Front. Endocrinol.

View full text Add to dashboard Cite

Substance P (SP) is a neuropeptide that is released from sensory nerve endings and is widely present in nerve fibers. It acts on bones and related tissues by binding to receptors, thereby regulating bone metabolism, cartilage metabolism, and fracture healing. SP has attracted widespread attention as a signaling substance that can be recognized by both the immune system and the nervous system. Previous studies have shown that bone and chondrocytes can synthesize and secrete sensory neuropeptides and express their receptors, and can promote proliferation, differentiation, apoptosis, matrix synthesis, and the degradation of target cells through autocrine/paracrine modes. In this paper, we review the research progress made in this field in recent years in order to provide a reference for further understanding the regulatory mechanism of bone and cartilage physiology and pathological metabolism.

show abstract

Section: Osteoporosismentioning

confidence: 99%

The Role of Substance P in the Regulation of Bone and Cartilage Metabolic Activity

Lin

et al. 2020

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…With the progress of the aging population in society, PMOP has became a frequent public health disease 18 . BSHX formula, severing as a complementary and alternative medicine, present an anti-PMOP effects in clinic and can prevent bone loss in OVX mice 8 , but its mechanism remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Exploring the mechanism of Bushenhuoxue formula acting on postmenopausal osteoporosis via network pharmacology and experimental validation

Wang²,

He³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Bushenhuoxue (BSHX) formula, a ten-compound herbal decoction, has been used to treat postmenopausal osteoporosis (PMOP) in China for decades. Our previous study also revealed the anti-PMOP effects of BSHX formula in ovariectomized (OVX) mice. However, its pharmacological mechanisms remain unknown. Methods: Network pharmacology followed by animal experiments was used to explore the action mechanism of BSHX formula. Firstly, we obtained the chemical compounds and potential targets of BSHX formula using TCMSP and TCMID databases. Simultaneously, GeneCards and DisGeNET databases were used to determine the targets in PMOP. Based on their overlapping genes between BSHX formula and PMOP, a protein-protein interaction (PPI) network was constructed for screening hub-targets. GO and KEGG enrichment analyses were further performed to identify the critical biological processes and signaling pathways. In vivo experimental study, an OVX mouse model was established to determine the anti-PMOP effects of BSHX formula via Micro-CT assay and ABH staining. The expressions of β-catenin, alkaline phosphatase (ALP), vascular endothelial growth factor (VEGF) and CD31 were detected by immunohistochemistry.Results: A total of 218 active ingredients and 274 related targets were identified in BSHX formula. After matching with 292 therapeutic targets of PMOP, 64 overlapping genes were obtained and further used to build a PPI network in which CTNNB1 and VEGFA played a central role. GO and KEGG enrichment analyses indicated that the anti-PMOP effects of BSHX formula were mainly associated with cell proliferation, angiogenesis and their regulated pathways including β-catenin signaling and VEGF signaling. In mouse experiments, we revealed that bone mass and blood vessels in the OVX mice were significantly enhanced after treated with BSHX formula for 8 weeks. Moreover, down-regulations of β-catenin, ALP, VEGF and CD31 caused by OVX surgery were significantly restored by BSHX formula.Conclusions: Through network pharmacology and an experimental validation, we have revealed that BSHX formula exerts anti-PMOP effects mainly through promoting β-catenin-mediated osteogenesis and VEGF-mediated angiogenesis. BSHX formula can be considered as a new option for the treatment of PMOP.

show abstract

“…[ 80 ] The neuropeptide can stimulate functional receptors on osteoblasts, promote cAMP production and downregulate osteoclast production. [ 81,82 ] Vasoactive intestinal peptide also promotes osteogenic differentiation of bone lineage cells, stimulates angiogenesis with enhanced tube formation of endothelial cells, and increases vascular endothelial growth factor expression in BMSCs. [ 83 ]…”

Section: Possible Signals From Intrabony Nerves To Bonementioning

confidence: 99%

Crosstalk between Bone and Nerves within Bone

et al. 2021

View full text Add to dashboard Cite

For the past two decades, the function of intrabony nerves on bone has been a subject of intense research, while the function of bone on intrabony nerves is still hidden in the corner. In the present review, the possible crosstalk between bone and intrabony peripheral nerves will be comprehensively analyzed. Peripheral nerves participate in bone development and repair via a host of signals generated through the secretion of neurotransmitters, neuropeptides, axon guidance factors and neurotrophins, with additional contribution from nerve‐resident cells. In return, bone contributes to this microenvironmental rendezvous by housing the nerves within its internal milieu to provide mechanical support and a protective shelf. A large ensemble of chemical, mechanical, and electrical cues works in harmony with bone marrow stromal cells in the regulation of intrabony nerves. The crosstalk between bone and nerves is not limited to the physiological state, but also involved in various bone diseases including osteoporosis, osteoarthritis, heterotopic ossification, psychological stress‐related bone abnormalities, and bone related tumors. This crosstalk may be harnessed in the design of tissue engineering scaffolds for repair of bone defects or be targeted for treatment of diseases related to bone and peripheral nerves.

show abstract

Postmenopausal osteoporosis is associated with the regulation of SP, CGRP, VIP, and NPY

Cited by 68 publications

References 40 publications

The Role of Substance P in the Regulation of Bone and Cartilage Metabolic Activity

The Role of Substance P in the Regulation of Bone and Cartilage Metabolic Activity

Exploring the mechanism of Bushenhuoxue formula acting on postmenopausal osteoporosis via network pharmacology and experimental validation

Crosstalk between Bone and Nerves within Bone

Contact Info

Product

Resources

About