Influence of vasospasm on visual function

Gasser, P.; Flammer, Josef

doi:10.1007/bf00144735

Cited by 113 publications

(48 citation statements)

References 56 publications

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“…Our findings support the hypothesis that peripheral vasospasm may be involved in the pathogenesis of LTG [6, 7]even in the absence of migraine, which is in agreement with the observations of Drance et al [8]and Gasser and Flammer [9]. Our LTG group had significantly greater maximum flow, and lower minimum flow after cold provocation compared to both normal and POAG groups.…”

Section: Discussionsupporting

confidence: 82%

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Blood Flow Velocity in the Peripheral Circulation of Glaucoma Patients

O’Brien¹,

Butt²

1999

Ophthalmologica

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Using the laser Doppler technique we measured finger blood flow velocity in 25 untreated primary open-angle glaucoma (POAG), 22 untreated low-tension glaucoma (LTG) and 19 age-matched normal subjects. Four blood flow measurements were recorded: baseline flow, after immersion in warm water for 2 min (40°C maximum flow), after 10 s exposure to cold water (4°C minimum flow) and time to recover to baseline flow after cold immersion. Significant differences between the LTG group and both the normal and POAG groups were found in a greater maximum flow (p = 0.03 and p = 0.01, respectively), a lower minimum flow (p = 0.04 and p = 0.03, respectively) and a longer recovery time to baseline flow (p = 0.0001 for both the normal and POAG groups). A longer recovery time to baseline flow (p = 0.008) in POAG was the only difference between the normal and POAG groups. Both glaucoma groups had more systemic vascular disease than normal, and there were more smokers in the POAG group than normals. Subgroup assessment performed with migraine, vascular disease and smoking subjects excluded from the analysis did not alter the overall results. We conclude that systemic vasospasm is a strong feature of low-tension glaucoma.

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Section: Discussionsupporting

confidence: 82%

“…Among these factors, the so-called ocular and peripheral vasospasm is thought to play a significant role [6, 7]. Drance et al [8]and later Gasser and Flammer [9]have measured finger blood flow velocity in glaucoma patients using laser Doppler and nailfold capillaroscopy techniques, respectively.…”

Section: Introductionmentioning

confidence: 99%

Blood Flow Velocity in the Peripheral Circulation of Glaucoma Patients

O’Brien¹,

Butt²

1999

Ophthalmologica

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“…Studien von Flammer [5], Flammer et al [6], Flammer und Guthauser [7] und Gasser und Flammer [8] weisen auf einen solchen Zusammenhang auch bei den primären Offenwinkelglaukomen eventuell mit einer vasospastischen Komponente, wie sie beispielsweise bei Migräne vorliegt, hin.…”

Section: Introductionunclassified

Okuläre Pulsamplitude bei okulärer Hypertension und verschiedenen Glaukomformen

Rückmann²,

Mittag³

1997

Ophthalmologica

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The present study was designed to investigate choroidal perfusion in primary open-angle glaucoma patients with statistically elevated (HPG) and statistically normal (NPG) intraocular pressure (IOP) and in ocular hypertensive volunteers (OHT) before and after application of topical antiglaucomatous drugs. When compared to age-matched healthy controls, ocular pulse amplitude (OPA) and IOP were significantly increased in OHT and unchanged in HPG; in NPG, the IOP was unchanged, and the OPA was significantly reduced. The topical antiglaucomatous drugs used in this study reduced IOP, but did not increase OPA. When compared to HPG and NPG, OHT subjects showed increased choroidal perfusion which may help to prevent glaucomatous optic nerve damage.

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“…Although previous reports have cited a high occurrence of functional peripheral vasospasm (up to about 65%), 20,23 only 16 LoGTS participants (8.4%) reported a history compatible with Raynaud's phenomenon.…”

Section: Vasospasmmentioning

confidence: 78%