Influence of Vitamin D & Calcium Supplementation in the Management of Periodontitis

Vitamin D levels and risk for periodontal disease: A systematic review

“…Only 1 study investigated the benefits of this supplementation but their analyses only focused on gingivitis and, therefore, it was not included in this review. Other studies used vitamin D supplementation along with other components involved in bone metabolism, such as calcium and teriparatide, showing overall good results; however, they were also excluded from this review as their actions appear to be synergistic, leading to confounding bias. The interventional studies included in this review provided post‐hoc or secondary analysis of studies planned to assess other objectives, importantly having small sample sizes probably leading to underpowered comparisons.…”

The Potential Role of Systemic Calcium in Periodontal Disease

“…Limitations of the study were the 3 months time frame and that medically compromised subjects with periodontitis were not included. 27 …”

“…24 Another study from India looked for any influence of calcium and vitamin D supplementation in periodontitis treatment outcome in otherwise healthy subjects whose serum calcium and vitamin D levels are in the normal range. 27 The primary objective was to evaluate the effect of vitamin D and calcium supplementation in the management of periodontitis. A secondary objective was to assess whether calcium and vitamin D oral supplementation influences alveolar density.…”

Vitamin D attenuates human gingival fibroblast inflammatory cytokine production following advanced glycation end product interaction with receptors for AGE

“…These activities contribute to the beneficial effects of 1,25D3 on oral health when used with conventional periodontal therapies. Dietary supplementation with 1,25D3 and calcium may improve periodontal health, and a recent review concluded that vitamin D plays a “perioprotective role,” by regulating innate and adaptive immune responses …”