Influence of VO2 Nanoparticle Morphology on the Colorimetric Assay of H2O2 and Glucose

Abstract

Nanozyme-based colorimetric sensors have received considerable attention due to their unique properties. The size, shape, and surface chemistry of these nanozymes could dramatically influence their sensing behaviors. Herein, a comparative study of VO2 nanoparticles with different morphologies (nanofibers, nanosheets, and nanorods) was conducted and applied to the sensitive colorimetric detection of H2O2 and glucose. The peroxidase-like activities and mechanisms of VO2 nanoparticles were analyzed. Among the VO2 nanoparticles, VO2 nanofibers exhibited the best peroxidase-like activity. Finally, a comparative quantitative detections of H2O2 and glucose were done on fiber, sheet, and rod nanoparticles. Under the optimal reaction conditions, the lower limit of detection (LOD) of the VO2 nanofibers, nanosheets, and nanorods for H2O2 are found to be 0.018, 0.266, and 0.41 mM, respectively. The VO2 nanofibers, nanosheets, and nanorods show the linear response for H2O2 from 0.025–10, 0.488–62.5, and 0.488–15.625 mM, respectively. The lower limit of detection (LOD) of the VO2 nanofibers, nanosheets, and nanorods for glucose are found to be 0.009, 0.348, and 0.437 mM, respectively. The VO2 nanofibers, nanosheets, and nanorods show the linear response for glucose from 0.01–10, 0.625–15, and 0.625–10 mM, respectively. The proposed work will contribute to the nanozyme-based colorimetric assay.

Peroxidase‐Like Activity of Smart Nanomaterials and Their Advanced Application in Colorimetric Glucose Biosensors

“…Owing to the shape, size, and surface chemistry of nanomaterials can dramatically influence their catalytic activities. A comparative study of peroxidase‐like activity of VO 2 nanomaterials with different morphologies (nanofibers, nanosheets, and nanorods) was reported by Qi et al The peroxidase‐like activity of various VO 2 nanomaterials was investigated upon catalysis of H 2 O 2 with peroxidase substrate TMB. Results showed that the VO 2 nanofibers showed a higher affinity for H 2 O 2 than VO 2 nanosheets, VO 2 nanorods, Fe 3 O 4 MNPs, and HRP.…”

“…The morphology and shape of nanomaterials also hold an important position in tuning their peroxidase‐like catalytic activity. In Qi's report, they synthesized vanadium dioxide nanomaterials with different morphologies (nanofibers, nanosheets, and nanorods) and compared their peroxidase‐like activities. Simultaneously, a comparative quantitative detections of glucose was done on nanofibers, nanosheets, and nanorods.…”

Antioxidant Materials Based on 2D Nanostructures: A Review on Recent Progresses

“…Aside from its peroxidase mimic, a layered V 2 O 5 2D structure was also used to detect GSH via an oxidase-type mechanism [147]. Lower valence state vanadium oxide, VO 2 was investigated in various morphologies [109]. Fibrillar, lamellar and elongated NPs were tested against TMB substrate and it was pointed out that VO 2 sheets exhibited the best kinetic overall parameters in regard of K m and v max .…”

Progress and Trend on the Regulation Methods for Nanozyme Activity and Its Application

“…The shape and morphology of nanozymes plays a key role in regulating their catalytic activity [49][50][51][52]. Tian et al have investigated the effect of different morphologies (nanosheets, nanofibers, and nanorods) of VO2 nanoparticles on the colorimetric assay for H2O2 and glucose [53]. It is found that VO2 nanofibers exhibit the highest peroxidase-like activity, since the specific surface area of VO2 nanofibers is much larger than that of VO2 nanosheets and nanorods.…”