Influence of water and food consumption on inadvertent antibiotics intake among general population

Ji, Kyunghee; Kho, Younglim; Park, Changu; Paek, Dohyeon; Ryu, Pan Dong; Paek, Domyung; Kim, Minyoung; Kim, Pan-Gyi; Choi, Kyungho

doi:10.1016/j.envres.2010.06.008

Cited by 94 publications

(48 citation statements)

References 35 publications

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“…These observations may indicate antibiotic therapy as a contributor to late-onset neonatal sepsis, as a significant proportion of these children are infected with bacterial species that were already present within the gut and these children received more antibiotics prior to septicaemia 16. In addition, low levels of antibiotics are known to contaminate food and water sources,3 suggesting a role for antibiotics in the dramatic increase in obesity and inflammatory diseases that could be independent of intentional antibiotic therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Since their introduction, medical antibiotic use has increased dramatically in the USA with a particular increase in the use of broad spectrum antibiotics in recent years 1. In addition, low-dose antibiotics have been used for agricultural purposes for >50 years,2 leading a nearly ubiquitous exposure to low levels of antibiotics in food and water for individuals who are not receiving antibiotic therapy for therapeutic purposes3 4 Epidemiological studies suggest that this increasing exposure to antibiotics is associated with an increased risk for developing inflammatory diseases including autoimmune disease, inflammatory bowel disease, coeliac disease, food allergy, asthma and obesity 5–11. The spectrum and number of inflammatory disorders associated with antibiotic use and the association of these disorders with a variety of antibiotics suggests that this increased risk is not due to side effects of specific antibiotics, but rather a shared effect across multiple antibiotics impacting a risk for general inflammatory responses.…”

Section: Introductionmentioning

confidence: 99%

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Antibiotics promote inflammation through the translocation of native commensal colonic bacteria

Knoop

McDonald

Kulkarni

et al. 2015

Gut

218

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Objective Antibiotic use is associated with an increased risk of developing multiple inflammatory disorders, which in turn are linked to alterations in the intestinal microbiota. How these alterations in the intestinal microbiota translate into an increased risk for inflammatory responses is largely unknown. Here we investigated if and how antibiotics promote inflammation via the translocation of live native gut commensal bacteria. Design Oral antibiotics were given to wildtype and induced mutant mouse strains and the effects on bacterial translocation, inflammatory responses, and the susceptibility to colitis were evaluated. The sources of the bacteria and the pathways required for bacterial translocation were evaluated using induced mutant mouse strains, 16s rRNA sequencing to characterize the microbial communities, and in vivo and ex vivo imaging techniques. Results Oral antibiotics induced the translocation of live native commensal bacteria across the colonic epithelium, promoting inflammatory responses, and predisposing to increased disease in response to coincident injury. Bacterial translocation resulted from decreased microbial signals delivered to colonic goblets cells (GCs), was associated with the formation of colonic goblet cell associated antigen passages (GAPs), was abolished when GCs were depleted, and required CX3CR1+ dendritic cells (DCs). Bacterial translocation occurred following a single dose of most antibiotics tested, and the predisposition for increased inflammation was only associated with antibiotics inducing bacterial translocation. Conclusions These findings reveal an unexpected outcome of antibiotic therapy and suggest that bacterial translocation as a result of alterations in the intestinal microflora may provide a link between increasing antibiotic use and the increased incidence of inflammatory disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antibiotics promote inflammation through the translocation of native commensal colonic bacteria

Knoop

McDonald

Kulkarni

et al. 2015

Gut

218

View full text Add to dashboard Cite

show abstract

“…The bioaccumulation of antibiotics in humans may cause hypersensitivity reactions, gastrointestinal disorders, liver damages, mutagenicity, carcinogenicity, and reproductive toxicity [ 40 , 41 ]. Several studies revealed that children are widely exposed to antibiotics from dietary intake at low dosage levels [ 42 , 43 , 44 ]. In addition, studies in mice revealed that exposure in low concentrations of residual antibiotics during developmental periods affects the metabolism, gut microbiota, and adipogenesis, which can lead to obesity and diabetes [ 45 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary Exposure Assessment of Veterinary Antibiotics in Pork Meat on Children and Adolescents in Cyprus

Kyriakides

Lazaris

Arsenoglou

et al. 2020

Foods

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In recent years, huge amounts of antibiotics have been administered to farm animals, and as a result, residues of these antibiotics can accumulate in livestock products and, once consumed, may be transmitted to humans. Farm animals’ antibiotic treatment may therefore present a risk for consumers health, especially for children and adolescents. In children, the immune system is not fully developed, and thus, they are more susceptible than adults to resistant bacteria. A dietary exposure assessment was conducted on veterinary antibiotics found in raw pork meat among children and adolescents in Cyprus, since pork is the most consumed red meat in Cypriot population. The study was based on the results of the occurrence of 45 residual antibiotics in raw pork meat samples in Cyprus between 2012 and 2017 in combination with data on the consumption of pork meat on children and adolescents taken from the latest demographic report in Cyprus. Estimated daily intake (EDI) values of veterinary antibiotics for children aged 6–9 years old, were higher compared to EDI values for adolescents aged 10–17 years old. The percentage ratio of the estimated daily intake to the acceptable daily intake for all the veterinary antibiotic residues was less than 5.6. The results indicate that antibiotic residues in pork meat of inland production are below the acceptable daily intake and are of low risk to human health related to the exposure of antibiotics. Nevertheless, continuous exposure to low levels of antibiotic residues in respect to age vulnerability should be of a great concern.

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“…Given that the mother had not been treated with antibiotics during pregnancy, delivery, and breastfeeding and that the first reaction occured at the start of a first treatment with amoxicillin, the child may have been sensitized by transplacental and/or breast milk transfer of penicillin contaminating foods ingested by his mother, and/or by direct ingestion of contaminated foods during his first year of life. It is well known that foods may be contaminated by drugs, that these drugs are excreted in the urine of exposed individuals , and can cause sensitization and allergic reactions . Moreover, it has been shown that drugs ingested by the mother can be transmitted to the children transplacentally and by breast milk .…”

mentioning

confidence: 99%

An unusual case of penile non‐pigmenting fixed drug eruption in a child

Keli-Bhija

Blic

Ponvert

2015

Pediatric Allergy Immunology

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Influence of water and food consumption on inadvertent antibiotics intake among general population

Cited by 94 publications

References 35 publications

Antibiotics promote inflammation through the translocation of native commensal colonic bacteria

Antibiotics promote inflammation through the translocation of native commensal colonic bacteria

Dietary Exposure Assessment of Veterinary Antibiotics in Pork Meat on Children and Adolescents in Cyprus

An unusual case of penile non‐pigmenting fixed drug eruption in a child

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