Influence of whole-body vibration time on peri-implant bone healing: a histomorphometrical animal study

Ogawa, Takumi; Possemiers, Tine; Zhang, Xiaolei; Naert, Ignace; Chaudhari, Amol; Sasaki, Keiichi; Duyck, Joke

doi:10.1111/j.1600-051x.2010.01637.x

Cited by 36 publications

(47 citation statements)

References 37 publications

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“…Since the process of osseointegration of oral implants involves the bone healing process, it was assumed that HF loading might positively affect peri-implant bone healing and osseointegration. Ogawa and co-workers have confirmed a bone anabolic response of HF loading, even when applied indirectly, on the peri-implant tissue mineralization in noncompromised rat bone [24]. This was discernible during the implant osseointegration cascade at tissue level already after 7 days of healing.…”

Section: Discussionmentioning

confidence: 72%

“…WBV experiments have evidenced the advantageous effects of HF loading on bone [16][17][18] and on titanium implant osseointegration [23]. Ogawa and co-workers recently reported, by means of rat animal experiments and quantitative histology, that HF loading via WBV can promote peri-implant bone healing and enhance implant osseointegration [23,24]. However, the latter-referred experiments did not make use of an impaired bone model.…”

Section: Introductionmentioning

confidence: 99%

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High-frequency loading positively impacts titanium implant osseointegration in impaired bone

et al. 2014

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Summary High-frequency loading via whole body vibration promotes bone formation and increases bone strength. Whether this translates to positive titanium implant osseointegration in osteoporotic bone was explored in this animal study. An anabolic effect of not only bisphosphonate treatment but also high-frequency loading on implant osseointegration in osteoporotic bone was observed. Introduction The present study investigated the impact of high-frequency (HF) loading, applied via whole body vibration (WBV), on titanium implant osseointegration in healthy versus ovariectomyinduced compromised versus pharmacologically treated compromised bone. Methods A custom-made Ti implant was inserted into the metaphyseal tibia of 59 rats and left to heal for either 4 or 14 days. Rats were divided into six groups according to their hormonal and mechanical status. WBV, consisting of 10 consecutive frequency steps at an acceleration of 0.3g, was applied daily for either 4 or 14 days. Tissue samples were processed for quantitative histology at the tibial cortical and medullar level. Data were analyzed by three-way ANOVA and by post hoc pairwise comparisons. Results The bone healing response at the interface and surrounding titanium implants was negatively influenced by osteoporotic bone conditions, mainly at the trabecular bone level. Furthermore, the administration of bisphosphonates for preventing the ovariectomy-induced impaired periimplant response was successful. Finally, the effect of HF WBV loading on the peri-implant bone healing was dependent on the bone condition and was anabolic solely in untreated osteoporotic trabecular bone when applied for an extended period of time. ConclusionsThe bone healing response to implant installation is compromised in osteoporotic bone conditions, in particular at the trabecular bone compartment. Meanwhile, not only pharmacological treatment but also mechanical loading via HF WBV can exert a positive effect on implant osseointegration in this specific bone micro-environment. The peri-implant cortical bone, however, seems to be less sensitive to HF WBV loading influences.

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Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

et al. 2014

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“…Animal studies suggested that in the presence of loading, osseointegration can occur early (Branemark et al, 1999) with greater deposition of mineralized tissue around the implant (Ogawa et al, 2011). This phenomenon suggests that functional stimulation could alter the osseointegration process through the release of molecules that act as modulators of osteogenesis and osteoclastogenesis.…”

Section: Introductionmentioning

confidence: 99%

Release of Bone Markers in Immediately Loaded and Nonloaded Dental Implants

et al. 2013

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“…Specifically, WBV seems to be superior to the localized loading. WBV has been found to extensively influence periimplant bone remodelling and hence led to significant increases of BIC and BF [17,18,35]. Compared with Load frequency affects implant healing X. Zhang et al 1701 the control, more than 10 per cent extra BIC was found in case of WBV after four weeks.…”

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confidence: 99%

In vivoassessment of the effect of controlled high- and low-frequency mechanical loading on peri-implant bone healing

Zhang

Vandamme

Torcasio

et al. 2012

J. R. Soc. Interface.

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The aim of this study was to investigate the effect of controlled high-(HF) and low-frequency (LF) mechanical loading on peri-implant bone healing. Custom-made titanium implants were inserted in both tibiae of 69 adult Wistar rats. For every animal, one implant was loaded by compression through the axis of tibia (test), whereas the other one was unloaded (control). The test implants were randomly distributed among four groups receiving different loading regimes, which were determined by ex vivo calibration. Within the HF (40 Hz) or LF (2 Hz) loading category, the magnitudes were chosen as low-(LM) and high-magnitude (HM), respectively, leading to constant strain rate amplitudes for the two frequency groups. This resulted in the four loading regimes: (i) HF-LM (40 Hz-0.5 N); (ii) HF-HM (40 Hz -1 N); (iii) LF-LM (2 Hz -10 N); and (iv) LF-HM (2 Hz -20 N) loading. Loading was performed five times per week and lasted for one or four weeks. Tissue samples were processed for histology and histomorphometry (bone-to-implant contact, BIC; and peri-implant bone fraction, BF) at the cortical and medullar level. Data were analysed statistically with ANOVA and paired t-tests with the significance level set at 0.05. For the one-week experiments, an increased BF adjacent to the implant surface at the cortical level was exclusively induced by the LF-HM loading regime (2 Hz-20 N). Four weeks of loading resulted in a significant effect on BIC (and not on BF) in case of HF-LM loading (40 Hz -0.5 N) and LF-HM loading (2 Hz -20 N): BIC at the cortical level significantly increased under both loading regimes, whereas BIC at the medullar level was positively influenced only in case of HF-LM loading. Mechanical loading at both HF and LF affects osseointegration and peri-implant BF. Higher loading magnitudes (and accompanying elevated tissue strains) are required under LF loading to provoke a positive peri-implant bone response, compared with HF loading. A sustained period of loading at HF is needed to result in an overall enhanced osseointegration.

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Influence of whole-body vibration time on peri-implant bone healing: a histomorphometrical animal study

Abstract: time of loading significantly influenced the effect of the WBV on peri-implant bone healing. Twice 1.25 min. of loading appears to have the most favourable effect. LMHF loading with a particular time sequence can stimulate peri-implant bone healing and formation.

Cited by 36 publications

References 37 publications

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

Release of Bone Markers in Immediately Loaded and Nonloaded Dental Implants

In vivoassessment of the effect of controlled high- and low-frequency mechanical loading on peri-implant bone healing

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