Release of Bone Markers in Immediately Loaded and Nonloaded Dental Implants

Prati, Alexandre Javaroni; Casati, Márcio Zaffalon; Ribeiro, Fernanda Vieira; Cirano, Fabiano Ribeiro; Pastore, Gabriel Pires; Pimentel, Suzana Peres; Casarin, Renato Corrêa Viana

doi:10.1177/0022034513504951

Cited by 26 publications

(32 citation statements)

References 28 publications

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“…Moreover, additional studies are required to investigate the profile of bone-related markers around implants in T2DM patients after functional loading, because loading may modulate bone mediator release around dental implants. 40 Furthermore, future longitudinal clinical evaluations of dental implants placed in diabetic individuals of differing glycaemic status are necessary to support the molecular outcomes of the present investigation and to determine the impact of hyperglycaemia on implant integration and on the rate of implant failure and complications in this patient profile group. The study of the mutual effects of the skeleton and the immune system at the cellular and molecular levels in T2DM conditions may allow the development of effective and safer therapeutic strategies in the coming years, in addition to providing evidence of the impact of glycaemic control in healing around implants.…”

Section: Discussionmentioning

confidence: 92%

Impact of type 2 diabetes on the gene expression of bone-related factors at sites receiving dental implants

Conte

Ghiraldini

Casarin

et al. 2015

International Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 92%

Impact of type 2 diabetes on the gene expression of bone-related factors at sites receiving dental implants

Conte

Ghiraldini

Casarin

et al. 2015

International Journal of Oral and Maxillofacial Surgery

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“…Their pilot study demonstrated that gene expression for OC was high 7 weeks after implant placement. Prati et al [32] studied the release of bone markers during the osseointegration period using the Luminex assay. They revealed that OC level was high 8 weeks after implant placement in their nonloaded group.…”

Section: Discussionmentioning

confidence: 99%

Relation between the stability of dental implants and two biological markers during the healing period: a prospective clinical study

Tirachaimongkol

Pothacharoen²,

Reichart

et al. 2016

Int J Implant Dent

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ObjectivesThe purposes of this study were to examine the correlation between the stability of dental implants and bone formation markers during the healing period and to monitor the stability of dental implants using the resonance frequency analysis (RFA) method. The null hypothesis of the study is no correlation between the stability of dental implant and bone formation markers.MethodsThe study is a prospective clinical study during the 3-month healing period of implant. At implant placement (PW Plus, Nakhon Pathom, Thailand) and after 1, 2, 3, 4, 6, 8, 10, and 12 weeks, RFA assessments were performed and gingival (GCF)/peri-implant crevicular fluids (PICF) were collected from ten patients. The level of osteocalcin (OC) was measured by using ELISA kits, and the level of alkaline phosphatase (ALP) activity was measured by colorimetric analysis. Repeated measures analysis of variance, the Friedman test, the Mann-Whitney U test, and the Pearson correlation were performed for data analysis.ResultsThere was a statistical decrease in the mean implant stability quotient (ISQ) values between 1 and 3 weeks (P < 0.05). The ISQ values recovered to the initial values at 4 weeks. There was no statistical difference in the ALP level at each measurement, while there was a statistical increase in the OC level at 6, 8, 10, and 12 weeks when compared with 1 week (P < 0.05). There was a significant correlation between ALP levels and ISQ values (r = 0.226, P < 0.05). There was a statistically significant correlation between OC levels and ISQ values at 1–12 weeks (r = 0.245, P < 0.05).ConclusionsThe ISQ values were weakly correlated with both ALP and OC. The three-thread-design implant showed a high stability through healing period.

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“…In addition, further studies are required to investigate the profile of bone-related biomarkers around implants in smoking patients after functional loading, because the loading might modulate bone mediator release around dental implants. 52 Another important and clinically interesting evaluation to be performed is the effect of bone cessation protocols on ''bone quality.'' Some studies have shown clinical and cellular benefits, 33,53,54 but no study has investigated the gene expression of bone-related markers.…”

Section: Discussionmentioning

confidence: 99%

Smoking Modulates Gene Expression of Type I Collagen, Bone Sialoprotein, and Osteocalcin in Human Alveolar Bone

Campos

Prati

Cirano

et al. 2015

Journal of Oral and Maxillofacial Surgery

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Release of Bone Markers in Immediately Loaded and Nonloaded Dental Implants

Cited by 26 publications

References 28 publications

Impact of type 2 diabetes on the gene expression of bone-related factors at sites receiving dental implants

Impact of type 2 diabetes on the gene expression of bone-related factors at sites receiving dental implants

Relation between the stability of dental implants and two biological markers during the healing period: a prospective clinical study

Smoking Modulates Gene Expression of Type I Collagen, Bone Sialoprotein, and Osteocalcin in Human Alveolar Bone

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