Influence of ZFHX3 Polymorphisms on the Risk of Ischemic Stroke in Chinese Han Population

Hu, Wei; Wang, Gang; Wang, Pei; Jin, Hong; Liu, Jianmin; Dang, Xingbo

doi:10.1007/s12012-023-09783-9

Cited by 2 publications

(2 citation statements)

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“…In addition, several studies have found that SNP rs7193343, located on ZFHX3 , is associated with prognostic recovery in cardioembolic stroke, a subtype of IS ( Gudbjartsson et al, 2009 ). Another study, Hu et al identified SNP rs879324, located on ZFHX3 , as an important factor influencing IS in the Chinese Han population by multifactor dimension reduction (MDR) software and least absolute shrinkage and selection operator (LASSO) logistic regression ( Hu et al, 2023 ). Tseveleki et al found that CREBBP , a gene related to the cellular stress response, was upregulated in a mouse model of permanent middle cerebral artery occlusion ( Tseveleki et al, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

“…Fan et al reported that CDKN1A/JUN could be a robust and promising gene-pair diagnostic biomarker for IS, regulating ferroptosis during IS progression via the C9orf106/C9orf139 -miR-22-3p -CDKN1A and GAS5-miR-139-5p/miR-429-JUN axes (Fan et al, 2022). In addition, several studies have found that SNP rs7193343, located on ZFHX3, is associated with prognostic recovery in cardioembolic stroke, a subtype of IS (Gudbjartsson et al, 2009) Frontiers in Genetics frontiersin.org 14 (Hu et al, 2023). Tseveleki et al found that CREBBP, a gene related to the cellular stress response, was upregulated in a mouse model of permanent middle cerebral artery occlusion (Tseveleki et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

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Integrated analysis of circRNA-associated ceRNA network in ischemic stroke

Fan

Wang

et al. 2023

Front. Genet.

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Introduction: Stroke, of which ischemic stroke (IS) is the major type, is the second leading cause of disability and death worldwide. Circular RNAs (circRNAs) are reported to play important role in the physiology and pathology of IS. CircRNAs often act as competing endogenous RNA (ceRNA) to regulate gene expression by acting as miRNA sponges. However, whole transcriptome-wide screenings of circRNA-mediated ceRNA networks associated with IS are still lacking. In the present study, we constructed a circRNA-miRNA-mRNA ceRNA network by whole transcriptome-wide analysis.Methods: CircRNAs, miRNAs and mRNAs expression profiles were downloaded from the Gene Expression Omnibus (GEO) datasets. We identified differentially expressed (DE) circRNAs, miRNAs, and mRNAs in IS patients. StarBase and CircBank databases were used to predict the miRNA targets of DEcircRNAs, and mirDIP database was used to predict the mRNA targets of DEmiRNAs. CircRNA-miRNA pairs and miRNA-mRNA pairs were established. Then, we identified hub genes via protein-protein interaction analysis and constructed a core ceRNA sub-network.Results: In total, 276 DEcircRNAs, 43 DEmiRNAs, and 1926 DEmRNAs were explored. The ceRNA network included 69 circRNAs, 24 miRNAs, and 92 mRNAs. The core ceRNA subnetwork included hsa_circ_0011474, hsa_circ_0023110, CDKN1A, FHL2, RPS2, CDK19, KAT6A, CBX1, BRD4, and ZFHX3.Discussion: In conclusion, we established a novel hsa_circ_0011474 - hsa-miR-20a-5p/hsa-miR-17-5p - CDKN1A ceRNA regulatory axis associated with IS. Our findings provide new insights into the pathogenesis of IS and offer promising diagnostic and predictive biomarkers.

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Section: Discussionmentioning

confidence: 99%