Influence of zinc hydroaspartate on the anti-inflammatory and gastric activity of ketoprofen in rats

Gaweł, Magdalena; Librowski, Tadeusz; Lipkowska, Anna

doi:10.1016/s1734-1140(13)70981-2

Cited by 7 publications

(2 citation statements)

References 14 publications

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“…Particularly, Zn 2+ was selected as a cross-linker cation because its antioxidant properties may boost the efficacy of the anti-inflammatory drug encapsulated in the polymeric matrix. 19,20 Formulations F5, F10, and F20 with different drug/polymer mass ratios (from 1:20 to 1:5, as shown in Table 1) were obtained in a few minutes. As control, blank Zn-alginate beads (F) were produced too.…”

Section: Resultsmentioning

confidence: 99%

Design and In Vivo Anti-Inflammatory Effect of Ketoprofen Delayed Delivery Systems

Cerciello

Auriemma

Morello

et al. 2015

Journal of Pharmaceutical Sciences

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Section: Resultsmentioning

confidence: 99%

Design and In Vivo Anti-Inflammatory Effect of Ketoprofen Delayed Delivery Systems

Cerciello

Auriemma

Morello

et al. 2015

Journal of Pharmaceutical Sciences

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“…The engineered particles were produced by prilling/ionotropic gelation technique using alginate as gastroresistant polymer carrier and zinc as cross-linking agent. Particularly, Zn 2+ was also selected for its anti-oxidant properties that may boost the efficacy of the anti-inflammatory drug encapsulated in the polymeric matrix [43,44]. After the production, hydrated particles were then exposed to standard room conditions (22 °C; 67% RH) for 12-18 h until constant weight was reached obtaining xerogel beads.…”

Section: Methodsmentioning

confidence: 99%

NSAIDS: Design and Development of Innovative Oral Delivery Systems

Auriemma¹,

Cerciello²,

Aquino³

2017

Nonsteroidal Anti-Inflammatory Drugs

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Recently, different technologies have been used to transform active pharmaceutical ingredients (APIs) into new dosage forms. Engineered drug delivery systems may modify biopharmaceutical properties of the API achieving either immediate or delayed release according to specific therapeutic needs. Particularly, preprogrammed release of oral formulations delivering the drug at expected times may be useful in chronotherapy of early morning pathologies. The conventional approach when dealing with such diseases is to administer NSAIDs two to three times daily. This approach does not allow to fit drug release with symptoms onset resulting in inefficient therapy and poor patient compliance. NSAIDs may be very effective if administered at least 4-6 h before the pain reaches its peak in the early morning. The solution could be to design delayed drug delivery systems allowing one administration before going to sleep acting in the early morning. This chapter highlights new approaches in developing controlled delivery systems of NSAIDs potentially useful to treat both acute and chronic inflammation. The chapter illustrates the versatility of laminar jet break-up technology (prilling) to produce gel beads able to control rate and time of drug delivery. A special focus will be on particle-engineering strategies, i.e., prilling and prilling technique in tandem with microwave or supercritical fluid-assisted drying.

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Zn(II) complex derived from bidentate Schiff base ligand: Synthesis, characterization, DFT studies and evaluation of anti-inflammatory activity

Azam

Al‐Resayes

Trzęsowska-Kruszyńska

et al. 2020

Journal of Molecular Structure

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Influence of zinc hydroaspartate on the anti-inflammatory and gastric activity of ketoprofen in rats

Abstract: ZHA enhanced the anti-inflammatory effect of ketoprofen.

Cited by 7 publications

References 14 publications

Design and In Vivo Anti-Inflammatory Effect of Ketoprofen Delayed Delivery Systems

Design and In Vivo Anti-Inflammatory Effect of Ketoprofen Delayed Delivery Systems

NSAIDS: Design and Development of Innovative Oral Delivery Systems

Zn(II) complex derived from bidentate Schiff base ligand: Synthesis, characterization, DFT studies and evaluation of anti-inflammatory activity

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