Influence of Zonisamide on the LTP-like Effect Induced by Quadripulse Transcranial Magnetic Stimulation (QPS)

Tanaka, Nobuyuki; Hanajima, Ritsuko; Tsutsumi, Ryosuke; Shimizu, Takahiro; Shirota, Yasuhiko; Terao, Yasuo; Ugawa, Yoshikazu

doi:10.1016/j.brs.2015.07.002

Cited by 12 publications

(5 citation statements)

References 19 publications

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“…18 These findings of dopamine agonist effects are consistent with the results from animal studies. Zonisamide mildly enhances LTP-like effects in M1, 23 possibly through induction of dopamine release 24,25 or MAO-B inhibition. 26 This LTP enhancement may partly explain the anti-Parkinsonian effects of zonisamide.…”

Section: Dopamine and Synap Tic Pl A S Ti Cit Y In Animal S And He Al...mentioning

confidence: 99%

Physiological changes in advanced Parkinson's disease: Altered motor cortical plasticity and its significance in pathophysiology and clinical symptoms

Shimizu

Hanajima

2023

Neurology & Clinical Neurosc

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Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neurodegeneration in the substantia nigra. Dopamine plays an important role in the induction of synaptic plasticity, and plastic changes in the brain have been broadly investigated in PD. In humans, non-invasive transcranial magnetic stimulation (TMS) has been widely used for plasticity induction in the motor cortex.In this review, we will discuss how dopamine receptors are involved in the induction of neuroplasticity, changes in corticostriatal plasticity in PD model animals, effects of dopamine on motor cortical plasticity in healthy humans, changes in motor cortical plasticity in PD patients including its relationship to motor symptoms, and, finally, altered plasticity in levodopa-induced dyskinesia.

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Section: Dopamine and Synap Tic Pl A S Ti Cit Y In Animal S And He Al...mentioning

confidence: 99%

Physiological changes in advanced Parkinson's disease: Altered motor cortical plasticity and its significance in pathophysiology and clinical symptoms

Shimizu

Hanajima

2023

Neurology & Clinical Neurosc

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“…82 Finally, 1 study in 24 participants has examined the influence of zonisamide (25 mg), a T-type VGCC antagonist, using QPS5. 90 In a crossover design, participants received either zonisamide or placebo before QPS5. The MEP amplitude trended higher with zonisamide on board, though this effect was not statistically significant.…”

Section: Ion Channels (5 Studies)mentioning

confidence: 99%

“…An important caveat to the literature to date is the predominance of small sample sizes and crossover designs, with only 4 studies using samples of 20 or more participants per group or crossover arm. 11,54,62,90 As such, while there appears to be broad alignment between the ex vivo tractable species literature and the human TMS literature, more adequately powered studies are required to determine if pharmacological adjuncts to rTMS plasticity protocols deviate from the preclinical literature.…”

Section: Limitationsmentioning

confidence: 99%

Pharmacological adjuncts and transcranial magnetic stimulation-induced synaptic plasticity: a systematic review

Sohn,

Brown,

Sharma

et al. 2024

jpn

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Background: Transcranial magnetic stimulation (TMS) is a noninvasive neurostimulation modality that has been used to study human synaptic plasticity. Leveraging work in ex vivo preparations, mechanistically informed pharmacological adjuncts to TMS have been used to improve our fundamental understanding of TMS-induced synaptic plasticity. Methods: We systematically reviewed the literature pairing pharmacological adjuncts with TMS plasticity-induction protocols in humans. We searched MEDLINE, PsycINFO, and Embase from 2013 to Mar. 10, 2023. Studies published before 2013 were extracted from a previous systematic review. We included studies using repetitive TMS, theta-burst stimulation, paired associative stimulation, and quadripulse stimulation paradigms in healthy and clinical populations. Results: Thirty-six studies met our inclusion criteria (28 in healthy and 8 in clinical populations). Most pharmacological agents have targeted the glutamatergic N-methyl-d-aspartate (NMDA; 15 studies) or dopamine receptors (13 studies). The NMDA receptor is necessary for TMS-induced plasticity; however, sufficiency has not been shown across protocols. Dopaminergic modulation of TMSinduced plasticity appears to be dose-dependent. The GABAergic, cholinergic, noradrenergic, and serotonergic neurotransmitter systems have small evidence bases supporting modulation of TMS-induced plasticity, as do voltage-gated calcium and sodium channels. Studies in clinical populations suggest that pharmacological adjuncts to TMS may rescue motor cortex plasticity, with implications for therapeutic applications of TMS and a promising clinical trial in depression. Limitations: This review is limited by the predominance in the literature of studies with small sample sizes and crossover designs. Conclusion: Pharmacologically enhanced TMS largely parallels findings from ex vivo preparations. As this area expands and novel targets are tested, adequately powered samples in healthy and clinical populations will inform the mechanisms of TMS-induced plasticity in health and disease.

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“…The lack of neural plasticity was normalized by taking L-Dopa in parallel with the improvement of motor symptoms (Enomoto et al 2012). Zonisamide, one of the anti-parkinsonian drugs, normalized the LTP-like effects by QPS5 in non-responder patients with Parkinson's disease (Tanaka et al 2015).…”

Section: Parkinson's Diseasementioning

confidence: 99%

Quadripulse stimulation (QPS)

Matsumoto

Ugawa

2020

Exp Brain Res

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Quadripulse stimulation (QPS) is a newly developed stimulation method to induce neural plasticity in humans. One stimulation burst consisting of four monophasic pulses is given every 5 s for 30 min. A total of 360 bursts (1440 pulses) are given in one session. Short-interval QPS potentiates the target cortical excitability and long-interval QPS depresses it. QPS at an inter-pulse interval of 5 ms (QPS5) induces long-term potentiation (LTP)-like effects most efficiently and QPS50 induces long-term depression (LTD)-like effects most effectively in the primary motor cortex. In this mini-review, we briefly introduce QPS: (i) principle and cortical plasticity (stimulators and protocols, synaptic plasticity, underlying mechanisms, metaplasticity, axonal plasticity, and drug effects), (ii) robust and strong neural plasticity induction (variability, influence of phasic muscle contraction, independency of BDNF polymorphism, sensory cortical plasticity, neural plasticity in the contralateral hemisphere, on-line effects on the brain networks, studies of normal brain physiology, and visuomotor sequence learning), (iii) therapeutic applications to neurological and psychiatric disorders (Parkinson's disease, epilepsy, cerebrovascular disease, and major depression), (iv) safety, and (v) future issues. Based on this evidence, we propose that QPS is currently the most powerful and reliable non-invasive brain stimulation method to induce neural plasticity in humans. Keywords Repetitive transcranial magnetic stimulation (rTMS) • Quadripulse stimulation (QPS) • Synaptic plasticity • Long-term potentiation (LTP) • Long-term depression (LTD) Abbreviations BCM Bienenstock-Cooper-Munro BDNF Brain-derived neurotrophic factor fMRI Functional magnetic resonance imaging LTD Long-term depression LTP Long-term potentiation M1 Primary motor cortex MEP Motor-evoked potential NIBS Non-invasive brain stimulation NIRS Near-infrared spectroscopy QPS Quadripulse stimulation rTMS Repetitive transcranial magnetic stimulation S1 Primary sensory cortex SEP Sensory-evoked potential SMA Supplementary motor cortex TMS Transcranial magnetic stimulation

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Influence of Zonisamide on the LTP-like Effect Induced by Quadripulse Transcranial Magnetic Stimulation (QPS)

Cited by 12 publications

References 19 publications

Physiological changes in advanced Parkinson's disease: Altered motor cortical plasticity and its significance in pathophysiology and clinical symptoms

Physiological changes in advanced Parkinson's disease: Altered motor cortical plasticity and its significance in pathophysiology and clinical symptoms

Pharmacological adjuncts and transcranial magnetic stimulation-induced synaptic plasticity: a systematic review

Quadripulse stimulation (QPS)

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