Influences of a standardized food matrix and gastrointestinal fluids on the physicochemical properties of titanium dioxide nanoparticles

Li, Yan; Jiang, Kun; Cao, Hui; Yuan, Min; Xu, Fei

doi:10.1039/d0ra09706c

Cited by 17 publications

(8 citation statements)

References 44 publications

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“…The lack of significant effect on

cells in mice fed

through food pellets could be due to the binding of food components on the NPs forming a protein/biomolecule corona, which could affect interaction with immune cells. Indeed, in vitro and/or in vivo studies demonstrated that food components influence the absorption and toxicity of inorganic NPs, such as zinc oxide (ZnO), 59 , 60 silver (Ag), 61 , 62 titanium dioxide (

), 63 , 64 and

. 65 , 66 In addition, amorphous silica NPs enhanced exogenous antigen entry and cross-presentation in vitro in murine DC, and this effect was suppressed after the modification of the NPs with either surface amine groups or carboxyl groups.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Effects of Chronic Oral Exposure to the Food Additive Silicon Dioxide on Oral Tolerance Induction and Food Sensitivities in Mice

Lamas,

Martins Breyner,

Malaisé

et al. 2024

Environ Health Perspect

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Background: The increasing prevalence of food sensitivities has been attributed to changes in gut microenvironment; however, ubiquitous environmental triggers such as inorganic nanoparticles (NPs) used as food additives have not been thoroughly investigated. Objectives: We explored the impact of the NP-structured food-grade silicon dioxide ( ) on intestinal immune response involved in oral tolerance (OT) induction and evaluated the consequences of oral chronic exposure to this food-additive using a mouse model of OT to ovalbumin (OVA) and on gluten immunopathology in mice expressing the celiac disease risk gene, HLA-DQ8. Methods: Viability, proliferation, and cytokine production of mesenteric lymph node (MLN) cells were evaluated after exposure to . C57BL/6J mice and a mouse model of OT to OVA were orally exposed to or vehicle for 60 d. Fecal lipocalin-2 (Lcn-2), anti-OVA IgG, cytokine production, and immune cell populations were analyzed. Nonobese diabetic (NOD) mice expressing HLA-DQ8 (NOD/DQ8), exposed to or vehicle, were immunized with gluten and immunopathology was investigated. Results: MLN cells exposed to presented less proliferative T cells and lower secretion of interleukin 10 (IL-10) and transforming growth factor beta ( ) by T regulatory and cells compared to control, two factors mediating OT. Mice given exhibited intestinal Lcn-2 level and interferon gamma ( ) secretion, showing inflammation and less production of IL-10 and . These effects were also observed in OVA-tolerized mice exposed to , in addition to a breakdown of OT and a lower intestinal frequency of T cells. In NOD/DQ8 mice immunized with gluten, the villus-to-crypt ratio was decreased while the intraepithelial lymphocyte counts and the Th1 inflammatory response were aggravated after treatment. Discussion: Our results suggest that chronic oral exposure to blocked oral tolerance induction to OVA, and worsened gluten-induced immunopathology in NOD/DQ8 mice. The results should prompt investigation on the link between exposure and food sensitivities in humans. https://doi.org/10.1289/EHP12758

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“…The lack of significant effect on

cells in mice fed

), 63 , 64 and

Section: Discussionmentioning

confidence: 99%

Evaluating the Effects of Chronic Oral Exposure to the Food Additive Silicon Dioxide on Oral Tolerance Induction and Food Sensitivities in Mice

Lamas,

Martins Breyner,

Malaisé

et al. 2024

Environ Health Perspect

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“…There was a slight reduction in particle size as the coated nanoparticles passed through the gastrointestinal tract, suggesting that there was some disruption of the nanoparticle aggregates. 48,49 This effect may have been due to the changes in solution conditions, molecular interactions, and enzyme activity discussed earlier. For instance, some of the whey proteins may have been hydrolyzed by digestive enzymes in the stomach and the small intestine.…”

Section: Particle Size and ζ-Potential Changes Duringmentioning

confidence: 98%

Impact of Whey Protein Corona Formation around TiO₂ Nanoparticles on Their Physiochemical Properties and Gastrointestinal Fate

Shan,

Guo,

et al. 2024

J. Agric. Food Chem.

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Previously, we found that whey proteins form biomolecular coronas around titanium dioxide (TiO 2 ) nanoparticles.Here, the gastrointestinal fate of whey protein-coated TiO 2 nanoparticles and their interactions with gut microbiota were investigated. The antioxidant activity of protein-coated nanoparticles was enhanced after simulated digestion. The structure of the whey proteins was changed after they adsorbed to the surfaces of the TiO 2 nanoparticles, which reduced their hydrolysis under simulated gastrointestinal conditions. The presence of protein coronas also regulated the impact of the TiO 2 nanoparticles on colonic fermentation, including promoting the production of short-chain fatty acids. Bare TiO 2 nanoparticles significantly increased the proportion of harmful bacteria and decreased the proportion of beneficial bacteria, but the presence of protein coronas alleviated this effect. In particular, the proportion of beneficial bacteria, such as Bacteroides and Bif idobacterium, was enhanced for the coated nanoparticles. Our results suggest that the formation of a whey protein corona around TiO 2 nanoparticles may have beneficial effects on their behavior within the colon. This study provides valuable new insights into the potential impact of protein coronas on the gastrointestinal fate of inorganic nanoparticles.

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“…The transformations of food-relevant NPs in the simulated gastrointestinal fluids have been investigated in several studies. 24,25,46,47 It has been shown that in simulated oral digestion step NP properties are relatively less modified than in the gastric or intestinal phases, 46,47 while protein corona formation on NPs in saliva has been shown to be NP type-dependent and potentially affect the digestive and antimicrobial properties of saliva. 48 However, previous studies have not considered the combined effects of the salivary environment and bacterial secreted compounds on NP transformation.…”

Section: Transformation Of Nps and Food-grade Tio 2 In Spent Artifici...mentioning

confidence: 99%

Food-related engineered nanoparticles and food-grade TiO₂ impact the metabolism of a human commensal bacterial strain in physiologically relevant conditions

Zhang

Huang

et al. 2023

Environ. Sci.: Nano

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Influences of a standardized food matrix and gastrointestinal fluids on the physicochemical properties of titanium dioxide nanoparticles

Abstract: In this study, a standardized food model (SFM) and simulated gastrointestinal fluids have been used to study the fate of e-TiO2-NPs following a three-step digestion model in vitro.

Cited by 17 publications

References 44 publications

Evaluating the Effects of Chronic Oral Exposure to the Food Additive Silicon Dioxide on Oral Tolerance Induction and Food Sensitivities in Mice

Evaluating the Effects of Chronic Oral Exposure to the Food Additive Silicon Dioxide on Oral Tolerance Induction and Food Sensitivities in Mice

Impact of Whey Protein Corona Formation around TiO₂ Nanoparticles on Their Physiochemical Properties and Gastrointestinal Fate

Food-related engineered nanoparticles and food-grade TiO₂ impact the metabolism of a human commensal bacterial strain in physiologically relevant conditions

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Influences of a standardized food matrix and gastrointestinal fluids on the physicochemical properties of titanium dioxide nanoparticles

Abstract: In this study, a standardized food model (SFM) and simulated gastrointestinal fluids have been used to study the fate of e-TiO2-NPs following a three-step digestion model in vitro.

Cited by 17 publications

References 44 publications

Evaluating the Effects of Chronic Oral Exposure to the Food Additive Silicon Dioxide on Oral Tolerance Induction and Food Sensitivities in Mice

Evaluating the Effects of Chronic Oral Exposure to the Food Additive Silicon Dioxide on Oral Tolerance Induction and Food Sensitivities in Mice

Impact of Whey Protein Corona Formation around TiO2 Nanoparticles on Their Physiochemical Properties and Gastrointestinal Fate

Food-related engineered nanoparticles and food-grade TiO2 impact the metabolism of a human commensal bacterial strain in physiologically relevant conditions

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Product

Resources

About

Impact of Whey Protein Corona Formation around TiO₂ Nanoparticles on Their Physiochemical Properties and Gastrointestinal Fate

Food-related engineered nanoparticles and food-grade TiO₂ impact the metabolism of a human commensal bacterial strain in physiologically relevant conditions