Influences of angiotensin I-converting enzyme gene insertion/deletion polymorphism on prostate cancer risk in Romania

PAVEL, ANCA GABRIELA; Stambouli, Danai; Gingu, C.; Preda, Adrian; Ismail, Gener; Baston, C.; Anton, Gabriela

doi:10.25083/rbl/24.6/1043.1049

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…There are several studies that have identified numerous genetic variants associated with PC risk and the aggressiveness of the disease 25 – 30 . In a review on the actual state of PC phenotype and GWASs, Pinto et al showed that even though GWASs provide insight on new genetic information on the aggressive form of PC, there is still a need to implement approaches to confirm these findings in independent populations.…”

Section: Discussionmentioning

confidence: 99%

Genetic variant located on chromosome 17p12 contributes to prostate cancer onset and biochemical recurrence

Pavel

Stambouli²,

Ismail

et al. 2022

Sci Rep

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The genetic contribution to prostate cancer (PC) onset and clinical heterogeneity has an important impact on the disease stratification accuracy. Despite the fact that radical prostatectomy (RP) is an effective treatment for localized PC, a considerable number of individuals develop biochemical recurrence (BCR) following surgery. In the present study, we decided to investigate the significance of genetic variability in a homogeneous group of Romanian men and to determine if genotyping could provide information regarding the possible implications of rs4054823 susceptibility loci in PC progression and outcome. A total of 78 samples from both PC and benign prostatic hyperplasia (BPH) patients were genotyped. The genotype frequencies were examined to see if there was a link between the 17p12 SNP and PC disease. When compared to the BPH group, the PC group had a significantly higher frequency of the T risk variant (P = 0.0056) and TT genotype (P = 0.0164). Subsequent analysis revealed that the TT genotype had a significantly higher frequency among younger PC patients based on their age at diagnosis and that it was related with a greater probability of BCR (P = 0.02). According to our findings, the TT genotype appears to be a risk factor for early-onset PC and a potential predictor for BCR after RP.

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Section: Discussionmentioning

confidence: 99%

Genetic variant located on chromosome 17p12 contributes to prostate cancer onset and biochemical recurrence

Pavel

Stambouli²,

Ismail

et al. 2022

Sci Rep

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“…Due to intensive research in recent years, a large volume of data concerning the association of SNPs with the overall risk for PC is available within the published literature. In genome-wide studies, multiple chromosomal regions have been associated with risk of PC onset and/or progression [ 14 , 15 , 16 , 17 , 18 ]. In this study, our main objective was to examine the cumulative effect of four common polymorphisms on the overall risk of PC.…”

Section: Discussionmentioning

confidence: 99%

Cumulative Effect Assessment of Common Genetic Variants on Prostate Cancer: Preliminary Studies

Pavel

Stambouli²,

Anton

et al. 2022

Biomedicines

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Single nucleotide polymorphisms (SNPs) are the most common type of genetic variation among people. Genome Wide Association studies (GWASs) have generated multiple genetic variants associated with prostate cancer (PC) risk. Taking into account previously identified genetic susceptibility variants, the purpose of our study was to determine the cumulative association between four common SNPs and the overall PC risk. A total of 78 specimens from both PC and benign prostate hyperplasia (BPH) patients were included in the study. Genotyping of all selected SNPs was performed using the TaqMan assay. The association between each SNP and the PC risk was assessed individually and collectively. Analysis of the association between individual SNPs and PC risk revealed that only the rs4054823 polymorphism was significantly associated with PC, and not with BPH (p < 0.001). Statistical analysis also showed that the heterozygous genotype of the rs2735839 polymorphism is more common within the BPH group than in the PC group (p = 0.042). The cumulative effect of high-risk alleles on PC was analyzed using a logistic regression model. As a result, the carriers of at least one risk allele copy in each particular region had a cumulative odd ratio (OR) of 1.42 times, compared to subjects who did not have any of these factors. In addition, the combination of these four genetic variants increased the overall risk of PC by 52%. Our study provides further evidence of the cumulative effects of genetic risk factors on overall PC risk. These results should encourage future research to explain the interactions between known susceptibility variants and their contribution to the development and progression of PC disease.

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“…Rennin angiotensin system (RAS) is a hormonal circulating system involved in systemic cardiovascular homeostasis, blood pressure regulation, neovascularization, inflammation, cell proliferation, and cell-cell adhesion. RAS has been investigated in different research studies as a prognostic biomarker and risk factor against different cancers, including prostate [2] and breast cancer [3]. In most of the neoplastic stages, overexpression of RAS components such as angiotensin II type I receptor Investigating the association of Angiotensin II Type I Receptor A1166C Polymorphism with Breast Cancer Risk in the Pakistani Population (AGTR1) and angiotensin-converting enzyme (ACE) has been reported [4].…”

Section: Introductionmentioning

confidence: 99%

Investigating the association of Angiotensin II Type I Receptor A1166C Polymorphism with Breast Cancer Risk in the Pakistani Population

Younas,

Shahid,

Khan

et al. 2024

Asian Pac J Cancer Prev

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The polymorphisms of the Renin-Angiotensin System are related to many disorders like diabetes, cardiovascular disease, and different types of cancer. Among all the polymorphisms related to AGTR1 , A1166C has been associated with several disorders, including cardiovascular diseases and breast cancer. This study was conducted to discover the association of AGTR1 polymorphism (A1166C) Renin-Angiotensin and its effect on the development and progression of breast cancer in the Pakistani population. One hundred forty participants, including seventy diagnosed breast cancer patients and seventy healthy individuals, were included in this study and genotyped with an allele-specific polymerase chain reaction. The most frequent genotype in healthy participants and breast cancer patients was CC. An insignificant (p value>0.05) risk of breast cancer was found with A1166C polymorphism in codominant (CC vs. AA OR=1.200 [0.256-5.631] and AC vs. AA 0.941 [OR=0.223-3.976]), dominant (OR=1.00 [0.240-4.167]), recessive (OR=1.230 [0.593-2.552]) and additive models (OR=1.028 [0.533-1.983]) of general population genotypes. Nonetheless, when the AA genotype was considered a reference group, a significant association was found between AC and CC genotypes and invasive ductal and ductal carcinoma development in breast cancer patients. In conclusion, this study demonstrated no significant association between AGTR1 (A1166C) polymorphism and breast cancer risk.

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Influences of angiotensin I-converting enzyme gene insertion/deletion polymorphism on prostate cancer risk in Romania

Cited by 3 publications

References 21 publications

Genetic variant located on chromosome 17p12 contributes to prostate cancer onset and biochemical recurrence

Genetic variant located on chromosome 17p12 contributes to prostate cancer onset and biochemical recurrence

Cumulative Effect Assessment of Common Genetic Variants on Prostate Cancer: Preliminary Studies

Investigating the association of Angiotensin II Type I Receptor A1166C Polymorphism with Breast Cancer Risk in the Pakistani Population

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