Influences of different adenosine receptor subtypes on catalepsy in mice

Zarrindast, Mohammad Reza; Modabber, M; Sabetkasai, M

doi:10.1007/bf02245707

Cited by 30 publications

(21 citation statements)

References 35 publications

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“…A similar inhibition by A2 (Simpson et al, 1992). It has also been invoked to explain the interactions of adenosine receptor agonists on catalepsy observed by Zarrindast et al (1993). It is interesting to note the lack of effect of CPX alone.…”

Section: Discussionmentioning

confidence: 84%

Anxiolytic activity of adenosine receptor activation in mice

Jain

Kemp

Adeyemo

et al. 1995

British J Pharmacology

113

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1 Purine analogues have been examined for anxiolytic-and anxiogenic-like activity in mice, by use of the elevated plus-maze.2 The selective Al receptor agonist, N6-cyclopentyladenosine (CPA) had marked anxiolytic-like activity at 1O and 50 gg kg-, with no effect on locomotor performance at these doses.3 The Al selective adenosine receptor antagonist, 1,3-dipropyl-8-cyclopentylxanthine (CPX) had no significant effect on anxiety-related measures or locomotor behaviour, but blocked the anxiolytic-like activity of CPA. The hydrophilic xanthine, 8-(p-sulphophenyl) theophylline did not prevent anxiolysis by CPA. 4 Caffeine had anxiogenic-like activity at 30 mg kg-' which was prevented by CPA at 50 Yg kg-. 5The A2 receptor agonist, Nl-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)-ethyl]adenosine (DPMA) had no effect on anxiety behaviour but depressed locomotor activity at the highest dose tested of 1 mg kg-'. The A2 receptor antagonist, 1,3-dimethyl-1-propargylxanthine (DMPX) had no effect on anxiety-related measures or locomotion and did not modify the anxiolytic-like activity of CPA. 6 Administration of DPMA in combination with anxiolytic doses of CPA prevented the anxiolytic-like activity of the latter.7 The results suggest that the selective activation of central Al adenosine receptors induces anxiolyticlike behaviour, while the activation of A2 sites causes locomotor depression and reduces the effects of Al receptor activation. The absence of any effect of CPX alone suggests that the receptors involved in modulating behaviour in the elevated plus-maze in mice are not activated tonically by endogenous adenosine.

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Section: Discussionmentioning

confidence: 84%

Anxiolytic activity of adenosine receptor activation in mice

Jain

Kemp

Adeyemo

et al. 1995

British J Pharmacology

113

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“…Catalepsy was evaluated by placing the animal with both forelegs over a horizontal glass bar (diameter: 0.5 cm) elevated 4.5 cm from floor (Sanberg et al 1988). The time (s) during which the mouse maintained this position was recorded for up to 300 s (Zarindast et al 1993). Catalepsy was considered finished when the forepaw touched the floor or when the mouse climbed upon the bar.…”

Section: Hanging-bar Testmentioning

confidence: 99%

Motor effects of acute and chronic inhibition of nitric oxide synthesis in mice

Bel

Souza

Guimarães³

et al. 2002

Psychopharmacology

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“…Adenosine A 2 A agonists show a clear separation between the doses inducing motor depression and ataxia (Heffner et al 1989). Furthermore, adenosine A 2 A agonists have been described to induce cata-lepsy after their central or systemic administration (Ferre et al 1991a;Zarrindast et al 1993;Kanda et al 1994;Hauber and Miinkle 1995;Kafka and Corbett 1996). Finally, adenosine A 2 A agonists, as well as A 1 agonists, have been reported to reduce conditioned avoidance responding (Martin et al 1993).…”

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confidence: 99%

Adenosine A2A Agonists: A Potential New Type of Atypical Antipsychotic

Rimondini¹

1997

Neuropsychopharmacology

143

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The systemic intraperitoneal (i.p.) The systemic administration of adenosine agonists in rodents has been shown to induce a pronounced dosedependent depression of spontaneous motor activity (Vapaatalo et al. 1975;Snyder et al. 1981;Durcan and Morgan 1989;Heffner et al. 1989;Nikodijevic et al. 1991;Jacobson et al. 1993;Ferre et al. 1994a). This behavioral effect is most probably mediated at the central level, since it is also induced after their intraventricular or intracerebral administration (Barraco et al. 1983(Barraco et al. , 1993. Furthermore, the administration of an adenosine antagonist which poorly penetrates the blood-brain barrier could not counteract an adenosine agonist-induced motor depression (Durcan and Morgan 1989b;Nikodijevic et al. 1991

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Influences of different adenosine receptor subtypes on catalepsy in mice

Cited by 30 publications

References 35 publications

Anxiolytic activity of adenosine receptor activation in mice

Anxiolytic activity of adenosine receptor activation in mice

Motor effects of acute and chronic inhibition of nitric oxide synthesis in mice

Adenosine A2A Agonists: A Potential New Type of Atypical Antipsychotic

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