Influences of protein films on antibacterial or bacteria-repellent surface coatings in a model system using silicon wafers

Antibacterial resin monomers based on quaternary ammonium and their benefits in restorative dentistry

“…This explanation is further supported by the observation that silicon wafer surfaces coupled with a high density of MDPB exhibited killing effects upon bacteria in contact with the surface [34]. What remains to be determined in the future is the detailed mechanism by which quaternary ammonium monomer-bearing polymers inhibit bacterial activity.…”

“…One limitation of modifying resinous materials with cationic monomers is that the modified surfaces are rather prone to protein adsorption and the adsorbed protein film can reduce the original antibacterial effects of the immobilized bactericide [34]. Such an effect of the adsorbed protein layer may be induced by the shielding of cationic surface charges, which are essential for the antibacterial activities [31][32][33].…”

Chlorhexidine delivery system from titanium/polybenzyl acrylate coating: Evaluation of cytotoxicity and early bacterial adhesion

“…Other researchers reported that surface properties do not seem to correlate with the grade of adhesion of Streptococcus Mutans on dental materials. 49 Mü ller et al, 50 demonstrated that proteins adsorbed from physiological fluids, such as serum and saliva, are able to significantly alter the physicochemical properties of underlying surfaces, which in turn greatly influences subsequent early bacterial aggregation. Protein layers generated by adsorption from physiological fluid increased or decreased Streptoccocus adhesion depending on the type of protein film and bacterial strain examined.…”

Novel self-etch adhesive with antibacterial and protein-repellent functions to prevent enamel demineralization

“…However, one drawback of QAMs is that the adsorption of salivary proteins on the surfaces could decrease the efficacy of "contact-inhibition" 56) . Indeed, several studies confirmed that a saliva-derived protein film on the cationic antibacterial surface reduced the original bactericidal effect 57,58) . The enzymatic MTT reduction can be used for assessment of the metabolic activity of microorganisms.…”