Influences of temperature and threshold effect of NaCl concentration on Alpias vulpinus OCT

Bellocco, Ersilia; Barreca, Davide; Laganà, Giuseppina; Tellone, Ester; Ficarra, Silvana; Migliardo, F.; Leuzzi, Ugo; Magazù, Salvatore; Galtieri, Antonio

doi:10.1016/j.ijbiomac.2008.09.008

Cited by 16 publications

(3 citation statements)

References 33 publications

(33 reference statements)

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“…As shown in our previous works [46,47], OCT activity decreased as a function of temperature and the value of T m for the enzyme (62.9 • C) increased in presence of some salt additives and trehalose.…”

Section: Discussionsupporting

confidence: 68%

Stabilization effects of kosmotrope systems on ornithine carbamoyltransferase

Barreca

Bellocco

Galli

et al. 2009

International Journal of Biological Macromolecules

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Section: Discussionsupporting

confidence: 68%

Stabilization effects of kosmotrope systems on ornithine carbamoyltransferase

Barreca

Bellocco

Galli

et al. 2009

International Journal of Biological Macromolecules

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“…As SLNs are composed of biocompatible and physiological lipids, they are less toxic than polymeric nanoparticles ( 67 ). They work well with both hydrophilic and lipophilic drugs, preventing contact with hydrophobic solvent macromolecules ( 68 ). SLNs are useful in the delivery of macromolecules by dermal, pulmonary, oral, intravenous, and ophthalmic routes ( 69 ).…”

Section: Classification Of Lbnpsmentioning

confidence: 99%

Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Waheed,

Ali,

Tabassum

et al. 2024

Front. Oncol.

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Cancer is a severe disease that results in death in all countries of the world. A nano-based drug delivery approach is the best alternative, directly targeting cancer tumor cells with improved drug cellular uptake. Different types of nanoparticle-based drug carriers are advanced for the treatment of cancer, and to increase the therapeutic effectiveness and safety of cancer therapy, many substances have been looked into as drug carriers. Lipid-based nanoparticles (LBNPs) have significantly attracted interest recently. These natural biomolecules that alternate to other polymers are frequently recycled in medicine due to their amphipathic properties. Lipid nanoparticles typically provide a variety of benefits, including biocompatibility and biodegradability. This review covers different classes of LBNPs, including their characterization and different synthesis technologies. This review discusses the most significant advancements in lipid nanoparticle technology and their use in medicine administration. Moreover, the review also emphasized the applications of lipid nanoparticles that are used in different cancer treatment types.

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“…The binding of molecules to macromolecules involves mainly non-covalent interactions (such as hydrogen bonds, van der Waals forces, hydrophobic, and electrostatic interactions). These types of forces can be analyzed by determining the thermodynamic parameters of the binding reaction [13,[28][29][30][31][32][33][34][35]. Therefore, the thermodynamic parameters dependent on temperature were calculated from the van't Hoff plot to characterize the forces acting between nitrofurantoin and HSA.…”

Section: Thermodynamics and Acting Forcesmentioning

confidence: 99%

Molecular Basis of Interactions between the Antibiotic Nitrofurantoin and Human Serum Albumin: A Mechanism for the Rapid Drug Blood Transportation

Calderaro

Maugeri

Magazù

et al. 2021

IJMS

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Nitrofurantoin is an antimicrobial agent obtained through the addition of a nitro group and a side chain containing hydantoin to a furan ring. The interactions of the antibiotic with human serum albumin (HSA) have been investigated by fluorescence, UV-VIS, Fourier transform infrared spectroscopy (FTIR) spectroscopy, and protein-ligand docking studies. The fluorescence studies indicate that the binding site of the additive involves modifications of the environment around Trp214 at the level of subdomain IIA. Fluorescence and UV-VIS spectroscopy, displacement studies, and FTIR experiments show the association mode of nitrofurantoin to HSA, suggesting that the primary binding site of the antibiotic is located in Sudlow’s site I. Molecular modeling suggests that nitrofurantoin is involved in the formation of hydrogen bonds with Trp214, Arg218, and Ser454, and is located in the hydrophobic cavity of subdomain IIA. Moreover, the curve-fitting results of the infrared Amide I’ band indicate that the binding of nitrofurantoin induces little change in the protein secondary structure. Overall, these data clarify the blood transportation process of nitrofurantoin and its rapid transfer to the kidney for its elimination, hence leading to a better understanding of its biological effects and being able to design other molecules, based on nitrofurantoin, with a higher biological potential.

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Influences of temperature and threshold effect of NaCl concentration on Alpias vulpinus OCT

Cited by 16 publications

References 33 publications

Stabilization effects of kosmotrope systems on ornithine carbamoyltransferase

Stabilization effects of kosmotrope systems on ornithine carbamoyltransferase

Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Molecular Basis of Interactions between the Antibiotic Nitrofurantoin and Human Serum Albumin: A Mechanism for the Rapid Drug Blood Transportation

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