Influences upon pediatricians&amp;rsquo; willingness to refer patients to clinical research

Dalen, Jeanne; Annett, Robert D.; Brody, Janet L.; Perryman, Mandy

doi:10.2147/oajct.s8244

Cited by 6 publications

(7 citation statements)

References 20 publications

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“…It is important for doctors and nurse clinicians to build effective communication with their patients to help alleviate fears relating to participation. Although it is recommended that physicians should proactively initiate research recruitment discussions with their patients, they have to remain watchful about the possibility of undue compulsion, which can lead to influence bias [20].…”

Section: Discussionmentioning

confidence: 99%

Attitude of Asian Parkinson Patients towards Clinical Research and Tissue Donation

Khan

Foo

Chia

et al. 2020

Parkinson's Disease

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Objective. e success of clinical research and tissue donation programs are highly dependent on recruitment of willing volunteers. A comprehensive survey of patient preferences and attitudes can help identify and address barriers hindering the recruitment for research. Method. is is a cross-sectional study on 105 Parkinson's disease patients who completed an interviewer-administered questionnaire. Results. Out of 105 respondents, 48% of patients had either already participated in clinical research or were keen to participate. About 80% believed clinical research to be safe for their health and privacy. More than 70% of participants were willing to donate blood, urine, or stool, while 16% were agreeable for cerebrospinal fluid sample donation. Motivating factors for clinical research included altruism (64%) and contribution to advance medical knowledge (64%). Common reasons for unwillingness towards clinical research included the risks involved (43%), time constraints (33%), and mobility challenges (24%). Conclusion. e attitude of Singaporean Parkinson patients toward clinical research and tissue donation is encouraging with about half of the participants willing to support clinical research. ree-quarters of patients would support tissue donations. Participation in research may be further increased with greater patient and public education to overcome misconceptions and also by limiting the demands of studies.

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Section: Discussionmentioning

confidence: 99%

Attitude of Asian Parkinson Patients towards Clinical Research and Tissue Donation

Khan

Foo

Chia

et al. 2020

Parkinson's Disease

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“…This suggested that increasing communication between trial investigators and veterinary practitioners could facilitate subject recruitment to veterinary clinical trials. 21 …”

Section: Discussionmentioning

confidence: 99%

“…A few studies 11,21,25,26 in human medicine have involved use of small groups of physicians and more in-depth discussions to explore attitudes toward clinical research. Although such studies generally have far fewer participants, the ability to ask follow-up questions can provide details not accessible through a survey tool, even with free-text options.…”

Section: Discussionmentioning

confidence: 99%

Attitudes of small animal practitioners toward participation in veterinary clinical trials

Gruen¹,

Griffith²,

Caney³

et al. 2017

javma

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OBJECTIVE To determine attitudes of small animal practitioners toward veterinary clinical trials and variables influencing their likelihood of participating in such trials. DESIGN Cross-sectional survey. SAMPLE Small animal practitioners with membership in 1 of 2 online veterinary communities (n = 163 and 652). PROCEDURES An online survey was developed for each of 2 veterinary communities, and invitations to participate were sent via email. Each survey included questions designed to collect information on the respondents’ willingness to enroll their patients in clinical trials and to recommend participation to clients for their pets. RESULTS More than 80% of respondents to each survey indicated that they spend no time in clinical research. A high proportion of respondents were likely or extremely likely to recommend clinical trial participation to clients for their pets when those trials involved treatments licensed in other countries, novel treatments, respected investigators, or sponsoring by academic institutions, among other reasons. Reasons for not recommending participation included distance, time restrictions, and lack of awareness of ongoing clinical trials; 28% of respondents indicated that they did not usually learn about such clinical trials. Most respondents (79% to 92%) rated their recommendation of a trial as important to their client’s willingness to participate. CONCLUSIONS AND CLINICAL RELEVANCE Participation in veterinary clinical trials by small animal practitioners and their clients and patients appeared low. Efforts should be increased to raise practitioner awareness of clinical trials for which patients might qualify. Specific elements of trial design were identified that could be modified to increase participation.

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“…Our findings suggest that as with pediatricians, scientific merit is an important contributor to nurses' attitudes about a study. (6) The majority were interested to know the results of the THAPCA trials, indicating a level of engagement beyond simply completing study procedures as part of their patient care duties. Presenting study results to clinical caregivers may ensure that these important research partners feel informed and valued, fostering interest in future research participation.…”

Section: Discussionmentioning

confidence: 99%

“…However, pediatricians are often reluctant to refer their patients for research studies (5, 6) due to potential risks from treatment side effects, patient inconvenience, lack of physician time/resources and risk to the doctor-patient relationship. (7-9)…”

Section: Introductionmentioning

confidence: 99%

Nurses’ Attitudes Toward Clinical Research

Browning

Page

Kuhn

et al. 2016

Pediatric Critical Care Medicine

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Objectives To understand factors affecting nurses' attitudes towards the Therapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) trials and association with approach/consent rates. Design, setting and participants Cross sectional survey of pediatric/cardiac intensive care nurses' perceptions of the trials, conducted at 16 of 38 self-selected study sites. Measurements The primary outcome was the proportion of nurses with positive perceptions, as defined by agree or strongly agree with the statement “I am happy to take care of a THAPCA patient”. Associations between perceptions and study approach/consent rates were also explored. Results Of 2241 nurses invited, 1387 (62%) completed the survey and 77% reported positive perceptions of the trials. Nurses, who felt positively about the scientific question, the study team, and training received, were more likely to have positive perceptions of the trials (p <0.001). Nurses who had previously cared for a research patient had significantly more positive perceptions of THAPCA compared with those who had not (79% vs. 54%, p<0.001). Of the 754 nurses who cared for a THAPCA patient, 82% had positive perceptions, despite 86% reporting it required more work. Sixty-nine percent believed that hypothermia reduces brain injury and mortality; sites had lower consent rates when their nurses believed that hypothermia was beneficial. Institution-specific approach rates were positively correlated with nurses' perceptions of institutional support for the trial (r=0.54, p=0.04), intensive care unit support (r=0.61, p=0.02), and the importance of conducting the trial in children (r=0.61, p=0.01). Conclusions The majority of nurses had positive perceptions of the THAPCA trials. Institutional, colleague and study team support and training were contributing factors. Despite increased work, nurses remained enthusiastic demonstrating that studies with intensive bedside nursing procedures are feasible. Institutions whose nurses believed hypothermia was beneficial had lower consent rates suggesting that educating nurses on study rationale and equipoise may enhance study participation.

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Influences upon pediatricians’ willingness to refer patients to clinical research

Cited by 6 publications

References 20 publications

Attitude of Asian Parkinson Patients towards Clinical Research and Tissue Donation

Attitude of Asian Parkinson Patients towards Clinical Research and Tissue Donation

Attitudes of small animal practitioners toward participation in veterinary clinical trials

Nurses’ Attitudes Toward Clinical Research

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