The use of particleboard has currently expanded, mainly due to the need for wood conservation. Therefore, this study aimed to evaluate the physical-mechanical properties and temperature variation of particleboards, by analyzing the addition of 1% ZnO nanoparticles in polyurethane resin based on castor oil, in comparison to particleboard without nanoparticles. The polyurethane resin offers enhanced performance in water contact and is formaldehyde-free, thus making it more sustainable. The properties assessed included density, moisture content, thickness swelling, water absorption, modulus of elasticity, and rupture modulus in static bending, following the specifications of Brazilian (ABNT NBR 14810: 2013), European (EN 312:2010), and American (ANSI 208:2018) standards. Additionally, the analysis included an assessment of pressing temperature variation. The results indicate that the addition of ZnO nanoparticles improved the properties of the particleboard, particularly in wet conditions, which are typically challenging for wood products. These enhancements can be attributed to the improved temperature variation facilitated by the nanoparticles, as observed through temperature analysis. Thus, the incorporation of nanoparticles contributed to the advantages of using a more sustainable resin, leading to advancements in the timber industry.