Influencia pronóstica de la pérdida de la expresión del antígeno del grupo sanguíneo A en el carcinoma no microcítico de pulmón en estadio I patológico

León-Atance, Pablo; Moreno-Mata, Nicolás; González-Aragoneses, Federico; Cañizares-Carretero, Miguel Ángel; Poblet-Martínez, Enrique; Genovés-Crespo, Marta; García-Jiménez, María Dolores; Honguero-Martínez, Antonio Francisco; Rombolá, Carlos A.; Simón-Adiego, Carlos María; Peñalver-Pacual, Rafael; Álvarez-Fernández, Emilio

doi:10.1016/j.arbres.2011.10.003

Cited by 9 publications

(4 citation statements)

References 22 publications

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“…For instance, A blood type is associated with risk of gastric cancer 14,15, attributed to A blood type alleles affected the fucosyltransferase enzymes which are involved in Lewis antigen formation known to be important factors in H. pylori adhesion and infection dentified by phenotype analysis 16. Likewise, A blood type is associated with unfavorable survivals in some other tumors, such as breast cancer 18,19, lung cancer 20,21 and so on. O blood type is associated with a reduced risk of pancreatic cancer 10-12, which may be attributed to ABO blood group IgM isoagglutinins interact with tumor-associated O-glycan structures in pancreatic cancer 12.…”

Section: Discussionmentioning

confidence: 99%

“…The ABO gene, located on chromosome 9q34.1 to 9q34.2, encodes a specific glycosyl transferase that synthesizes A and B agglutinogens to form the ABO blood type agglutinogens 7, expressed by erythrocytes, most epithelial cells, endothelial cells and so on8. Relationship between the ABO blood type and prognosis have been reported in many tumor types, such as leukemia 9, pancreatic cancer 10-12, bladder cancer 13, gastric cancer 14-16, renal cell carcinoma 17, breast cancer 18,19, lung cancer 20,21 and so on.…”

Section: Introductionmentioning

confidence: 99%

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O Blood Type Is Associated with Unfavorable Distant-metastasis-free Survival in Female Patients with Nasopharyngeal Carcinoma: A Retrospective Study of 2439 Patients from Epidemic Area

Wang¹,

Zhou²,

Chen³

et al. 2019

J. Cancer

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Purpose : To identify the association between ABO blood type and the survivals in nasopharyngeal carcinoma patients. Patients and methods : We retrospectively analyzed 2439 consecutive non-metastasis nasopharyngeal carcinoma patients between January 2001 and December 2004 at the Sun Yat-sen University Cancer Center. Survival outcomes were compared using Kaplan-Meier method. Univariate and multivariate analysis was performed by Cox regression model. Chi-square test was performed to compare categorical variables. Results : In the whole patients, compared with non-O blood type (A, B, and AB) patients, O blood type patients had significantly lower 5-year distant metastasis-free survival (DMFS) (adjusted hazard ratio (aHR)= 1.268, 95% CI 1.010-1.592, P=0.041). Moreover, we observed in female patients, O blood type patients had significantly lower 5-year overall survival (OS), disease-specific survival (DSS) and DMFS than those with non-O blood type (aHR=1.495, 95% CI 1.032-2.165, P=0.034 for OS; aHR=1.566, 95% CI 1.054-2.328, P=0.026 for DSS; aHR=1.779, 95% CI 1.056-2.998, P=0.030 for DMFS). In male patients, there was no significant difference observed between O blood type patients and non-O blood type patients in any survival endpoints. Conclusion : O blood type was associated with an unfavorable DMFS in female patients with nasopharyngeal carcinoma in epidemic area, which might contribute to unfavorable OS and DSS in female patients, even contribute to a lower DMFS in the whole patients. It might be beneficial to predict metastasis so as to guide the treatment in female patients with nasopharyngeal carcinoma in epidemic area.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

O Blood Type Is Associated with Unfavorable Distant-metastasis-free Survival in Female Patients with Nasopharyngeal Carcinoma: A Retrospective Study of 2439 Patients from Epidemic Area

Wang¹,

Zhou²,

Chen³

et al. 2019

J. Cancer

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“…The increase of H-antigen correlates with the loss of A- and B-transferases expression and activity in red blood cells at the preleukemic stage ( 262 ), bladder malignant urothelium cells ( 263 ), and oral epithelia ( 264 ). The loss of blood group antigen A expression has a negative prognostic impact in stage I non-small cell lung cancer, especially in patients with adenocarcinoma ( 265 ). The increase in H epitope in cancer cells is related to α1-2FucT overexpression.…”

Section: Lewis and Abh Blood Group Antigensmentioning

confidence: 99%

Biosynthetic Machinery Involved in Aberrant Glycosylation: Promising Targets for Developing of Drugs Against Cancer

Vasconcelos-dos-Santos

et al. 2015

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Cancer cells depend on altered metabolism and nutrient uptake to generate and keep the malignant phenotype. The hexosamine biosynthetic pathway is a branch of glucose metabolism that produces UDP-GlcNAc and its derivatives, UDP-GalNAc and CMP-Neu5Ac and donor substrates used in the production of glycoproteins and glycolipids. Growing evidence demonstrates that alteration of the pool of activated substrates might lead to different glycosylation and cell signaling. It is already well established that aberrant glycosylation can modulate tumor growth and malignant transformation in different cancer types. Therefore, biosynthetic machinery involved in the assembly of aberrant glycans are becoming prominent targets for anti-tumor drugs. This review describes three classes of glycosylation, O-GlcNAcylation, N-linked, and mucin type O-linked glycosylation, involved in tumor progression, their biosynthesis and highlights the available inhibitors as potential anti-tumor drugs.

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“…An increasing number of researchers have recorded that the ABO blood group is involved in several disorders and pathological condition as it has already mentioned and the possible link between ABO blood group and susceptibility to chronic disease as an example of genetic basis for family predisposition, has also been investigated [4]. To be more specific an association between inherited human ABO blood group antigens with diseases such as coronary heart disease [5], ischemic stroke [6,7] and several types of malignancies [2,[8][9][10][11][12][13][14][15] has been recorded.…”

Section: Introductionmentioning

confidence: 99%

ABO Blood Group System and Periodontal Disease Indices: A Cross-Sectional Study in Greek Adults

Chrysanthakopoulos

2021

Asp Biomed Clin Case Rep

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Introduction: Periodontal disease (PD) development has been associated with the presence of causative microorganisms, host immunity and risk factors, whereas the types of periodontal diseases are characterized by interactions between host and bacteria. Moreover, ABO blood groups are the most investigated erythrocyte antigen system. However, a small number of researches have been focused on the possible associations between ABO blood groups and periodontal diseases. Methods: A cross-sectional, epidemiological study was carried out on 854 individuals, 404 males and 450 females, aged 45 to 77. The study sample was interviewed and underwent an oral and dental clinical examination. The assessment of the possible associations between several indices of PD, such as Probing Pocket Depth (PPD), Clinical Attachment Loss (CAL) and Bleeding on Probing (BOP) as dependent variables and ABO blood groups A, B, AB, and O as independent ones was carried out by using a multiple regression analysis model. Results: Individuals with blood group A [OR= 2.94, 95% CI = 1.27-3.96] and B [OR= 2.66, 95% CI = 1.11-3.87] were significantly associated with the risk of developing deeper periodontal pockets (PPD) and worse values of attachment loss (CAL) [OR= 2.42, 95% CI= 1.37-3.85] and [OR= 2.31,95% CI=1.25-3.68], respectively. However, no significant associations were recorded between ABO blood groups and BOP [OR= 1.04, 95% CI= 0.92-1.18]. Conclusion: A significant association was revealed between A and B blood groups and deeper periodontal pockets and worse attachment loss, whereas no associations were observed between ABO blood groups and bleeding of probing.

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Influencia pronóstica de la pérdida de la expresión del antígeno del grupo sanguíneo A en el carcinoma no microcítico de pulmón en estadio I patológico

Cited by 9 publications

References 22 publications

O Blood Type Is Associated with Unfavorable Distant-metastasis-free Survival in Female Patients with Nasopharyngeal Carcinoma: A Retrospective Study of 2439 Patients from Epidemic Area

O Blood Type Is Associated with Unfavorable Distant-metastasis-free Survival in Female Patients with Nasopharyngeal Carcinoma: A Retrospective Study of 2439 Patients from Epidemic Area

Biosynthetic Machinery Involved in Aberrant Glycosylation: Promising Targets for Developing of Drugs Against Cancer

ABO Blood Group System and Periodontal Disease Indices: A Cross-Sectional Study in Greek Adults

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