Influencing factors of stroke occurrence and recurrence in hypertensive patients: A prospective follow‐up studies

Abstract

Objective To understand the related risk factors of occurrence and recurrence of hypertension and provide scientific basis for relevant departments to better guide prevention and control work. Methods From September 2017 to September 2018, a prospective follow‐up study was performed on patients with hypertension who visited the Second People's Hospital of Wuhu City, Anhui Province. Multivariate Cox regression was used to analyze influencing factors of stroke occurrence and recurrence in follow‐up of hypertensive patients. Results A total of 769 hypertensive patients were enrolled in this study. The average age of hypertensive patients was 65.66 ± 11.70 years old and the BMI index was 24.99 ± 4.17. In this study, 769 patients with hypertension were followed up for 1 year, and the incidence of stroke was 14.69%. This study found that higher levels of blood glucose (RR = 2.027, 95% CI: 1.195–3.438), HCY (RR = 5.928,95% CI: 1.438–24.440), aggravated extent of carotid artery stenosis (RR = 2.620, 95% CI: 1.532–4.481), and drinking (RR = 3.867, 95% CI: 2.038–7.339) were risk factors, and maintaining exercise (RR = 0.325, 95% CI: 0.117–0.907) was a protective factor for stroke occurrence; however, aggravated extent of carotid artery stenosis (RR = 3.158, 95% CI: 1.797–5.550) and smoking (RR = 2.271, 95% CI: 1.142–4.517) were risk factors for stroke recurrence for hypertensive patients. Conclusions For people with high blood pressure, it is necessary to exercise properly, control body weight, avoid obesity, quit smoking, reduce alcohol consumption, and reasonably control blood pressure, blood sugar, and blood lipid.

Association of Antihypertensive Drug-Related Gene Polymorphisms with Stroke in the Chinese Hypertensive Population

“…This study revealed that the prevalence of stroke in the hypertensive population in Changsha County of Hunan Province was 2.75%, which was significantly lower than the 10.04% reported in hospitalized hypertensive patients in the Anhui Province [ 31 ]. The difference may be a result of differences in the study population, with the hospitalized population having more difficulty in controlling BP and higher-grade hypertension than the community population.…”

“…This finding suggests that hypertensive patients comorbid with coronary heart disease or diabetes may modify the association of ADRB1 ( 1165G > C ) polymorphisms with stroke. In patients only with elevated BP, the CC genotype was the main risk factor for stroke; in hypertensive patients with other comorbid conditions, many nongenetic factors related to coronary heart disease or diabetes, such as smoking, physical activities, and dietary factors [ 31 , 45 , 46 ], might affect stroke development and conceal the association of ADRB1 ( 1165G > C ) gene polymorphism with stroke. Similarly, a meta-analysis revealed no significant association of ADRB1 ( 1165G > C ) polymorphisms with cardiovascular events in patients with coronary artery disease [ 47 ].…”