Influenza A(H1N1) vaccination during early pregnancy transiently promotes hippocampal neurogenesis and working memory. Involvement of Th1/Th2 balance

Xia, Yucen; Qi, Fangfang; Zou, Juntao; Ye, Zhibin

doi:10.1016/j.brainres.2014.09.076

Cited by 26 publications

(29 citation statements)

References 46 publications

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“…Consistent with our results, Nunan R et al have well demonstrated that VIP, a neuropeptide released by the interneurons in DG, enhances the pro-neurogenic effect of microglia via IL-4 release [34]. However, a dominant shift in favor of Th2 bias identified by the IFN-γ: IL-4 ratio indeed regulates negatively hippocampal neurogenesis independent of IL-4 level [8,10]. The underlying mechanism by which the Th2 bias regulates hippocampal neurogenesis is incompletely understood.…”

Section: How Systemic Th1/th2 Cytokine Balance Modulates Adult Hippocsupporting

confidence: 88%

“…Pregnant mice display a decrease in hippocampal neurogenesis followed by a down-regulation in systemic Th1/Th2 balance [14,15]. However, this neuronal deficit can be reversed by influenza vaccination, which is known to induce Th1 bias during early pregnancy [10]. Importantly, there exists a positive correlation between the interferon (IFN)-γ to interleukin (IL)-4 ratio and hippocampal Brain-derived neurotrophic factor (BDNF) levels, further supporting our viewpoint [10].…”

Section: Th1 Bias and Adult Hippocampal Neurogenesissupporting

confidence: 72%

“…Recent researches also provide excellent evidence that stress-induced hippocampal neurogenesis alteration in DG is accompanied by Th1/Th2 balance changing in the periphery [8,9]. Together with our recent studies [10,11], we have proposed a concept that underlying mechanism of immune system affecting the CNS is not just regulated by a certain cytokine but rather regulated by many cytokines [12], which are correlated with systemic Th1/Th2 cytokine balance, for modulation of elaborated brain functions. Importantly, other reports indeed shed light on the correlation between systemic Th1/Th2 balance and adult hippocampal neurogenesis [8,13]; although recent data indicate that the dichotomous categorization of helper T lymphocyte into Th1 and Th2 has become gradually blurred.…”

Section: Introductionsupporting

confidence: 56%

“…A model of modest exercise-training, which is widely recognized to increase adult hippocampal neurogenesis, causes Th1 bias via up-regulating interferon gamma (IFN-γ) levels in the periphery [11]. We recently showed that influenza A (H1N1) vaccination during early pregnancy transiently promote adult hippocampal neurogenesis, potentially via the restoration of the balance of Th1/Th2 [10]. Pregnant mice display a decrease in hippocampal neurogenesis followed by a down-regulation in systemic Th1/Th2 balance [14,15].…”

Section: Th1 Bias and Adult Hippocampal Neurogenesismentioning

confidence: 99%

“…However, this neuronal deficit can be reversed by influenza vaccination, which is known to induce Th1 bias during early pregnancy [10]. Importantly, there exists a positive correlation between the interferon (IFN)-γ to interleukin (IL)-4 ratio and hippocampal Brain-derived neurotrophic factor (BDNF) levels, further supporting our viewpoint [10]. Furthermore, one mouse model of rheumatoid arthritis used by Wolf, S.A. et al characterized by a Th1-dependent local inflammation of the knee joints increases proliferation of neural precursor cells in the adult hippocampus [5], as can be seen in Table 1.…”

Section: Th1 Bias and Adult Hippocampal Neurogenesismentioning

confidence: 99%

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Immune-Based Modulation of Adult Hippocampal Neurogenesis, Link to Systemic Th1/Th2 Balance

Qi¹,

Xia²,

Zuo³

et al. 2015

J Vaccines Vaccin

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The interaction between adaptive immune system and the Central Nervous System (CNS) has been extensively studied for decades. A series of researches have indicated that systemic T cells, particularly CD4 + T cells are involved in supporting fundamental processes of brain functional integrity, such as in the maintenance of brain plasticity including spatial learning and memory, and neurogenesis. Moreover, recent data from our laboratory indicate alteration of systemic T helper cell type 1 (Th1)/Th2 balance is tightly linked to hippocampal neurogenesis and working memory. In this review, we summarize current knowledge of the systemic Th1/Th2 balance, describe how this skewing appears to operate in hippocampal neurogenesis, and reinforce the theory of interaction mechanism of these two vital systems.

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Section: How Systemic Th1/th2 Cytokine Balance Modulates Adult Hippocsupporting

confidence: 88%

Section: Th1 Bias and Adult Hippocampal Neurogenesissupporting

confidence: 72%

Section: Introductionsupporting

confidence: 56%

Section: Th1 Bias and Adult Hippocampal Neurogenesismentioning

confidence: 99%

Section: Th1 Bias and Adult Hippocampal Neurogenesismentioning

confidence: 99%

See 3 more Smart Citations

Immune-Based Modulation of Adult Hippocampal Neurogenesis, Link to Systemic Th1/Th2 Balance

Qi¹,

Xia²,

Zuo³

et al. 2015

J Vaccines Vaccin

Self Cite

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Blocking B7-1/CD28 Pathway Diminished Long-Range Brain Damage by Regulating the Immune and Inflammatory Responses in a Mouse Model of Intracerebral Hemorrhage

Shen

Gao

et al. 2016

Neurochem Res

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Acute brain injuries can activate bidirectional crosstalk between the injured brain and the immune system. The immune system, particularly T lymphocytes and cytokines, has been implicated in the progression of brain injury after intracerebral hemorrhage (ICH). Co-stimulatory molecules B7-1 (CD80)/B7-2 (CD86) binding cognate receptor provides a secondary signaling to T cell activation. The aim of our study was to explore the effects of anti-B7-1 antibody on the development and prognosis of cerebral hemorrhage and to investigate the possible underlying mechanism. Mice were inner canthus veniplex administered with anti-B7-1 antibody at 10 min and 24 h after ICH and sacrificed on the third day after ICH. Immune function was assessed via splenocyte proliferation assay and organism index, respectively. IFN-γ and IL-4 were detected by enzyme-linked immuno sorbent assay. The cerebral edema was evaluated via brain water content. The levels of autophagy and apoptosis related proteins were measured by western blotting analysis. In addition, functional outcome was studied with pole-climbing test and morris water maze. The mice were weighed on 0, 1, 3, 14 and 21 days after ICH. The treatment with anti-B7-1 antibody significantly lowered immune function, and reduced the latency of water maze on 18 and 20 days, the ratio of IFN-γ/IL-4 as well as body weight on day 3 after cerebral hemorrhage. Our study suggests that in the cerebral hemorrhage mice brain anti-B7-1 antibody may reduce long-range brain damage by reversing immune imbalance.

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IgE low affinity receptor (CD23) expression, Plasmodium falciparum specific IgE and tumor necrosis factor-alpha production in Thai uncomplicated and severe falciparum malaria patients

et al. 2016

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Previous studies have suggested that Plasmodium falciparum (P. falciparum) specific IgE in the form of immune complexes crosslinking the low-affinity receptor (CD23) on monocyte results in tumor necrosis factor (TNF)-α and nitric oxide (NO) production. However, the roles of these parameters in severity and immune protection are still unclear. This study aimed to determine the association between CD23 expression on monocytes, plasma soluble CD23 (sCD23), total IgE, malaria-specific IgE and IgG, and TNF-α levels in P. falciparum infected patients. We evaluated 64 uncomplicated (UC) and 25 severe patients (S), admitted at the Hospital for Tropical Diseases, Mahidol University, and 34 healthy controls (C) enrolled in 2001. Flow cytometry and enzyme linked immunosorbent assays (ELISA) demonstrated that trends of the CD23 expression, levels of sCD23 and specific IgE were higher in the S group as compared to those in the UC and C groups. Plasma levels of P. falciparum specific IgE in the UC (p=0.011) and S groups (p=0.025) were significantly higher than those in C group. In contrast the TNF-α levels tended to be higher in the UC than those in the S (p=0.343) and significantly higher than those in C (p=0.004) groups. The specific IgG levels in UC were significantly higher than those in S and C (p<0.001) groups. At admission, a strong significant negative correlation was found between specific IgG and sCD23 (r=-0.762, p=0.028), and TNF-α and IgE-IgG complexes (r=-0.715, p=0.002). Significant positive correlations between levels of specific IgE and TNF-α (r=0.575, p=0.010); and sCD23 (r=0.597, p=0.000) were also observed. In conclusion, our data suggest that CD23 expression and malaria-specific IgE levels may be involved in the severity of the disease while TNF-α and the malaria-specific IgG may correlate with protection against falciparum malaria.

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Influenza A(H1N1) vaccination during early pregnancy transiently promotes hippocampal neurogenesis and working memory. Involvement of Th1/Th2 balance

Cited by 26 publications

References 46 publications

Immune-Based Modulation of Adult Hippocampal Neurogenesis, Link to Systemic Th1/Th2 Balance

Immune-Based Modulation of Adult Hippocampal Neurogenesis, Link to Systemic Th1/Th2 Balance

Blocking B7-1/CD28 Pathway Diminished Long-Range Brain Damage by Regulating the Immune and Inflammatory Responses in a Mouse Model of Intracerebral Hemorrhage

IgE low affinity receptor (CD23) expression, Plasmodium falciparum specific IgE and tumor necrosis factor-alpha production in Thai uncomplicated and severe falciparum malaria patients

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