Influenza virus-induced interferon production in mouse spleen cell culture: T cells as the main producer

Relationship between the Production of Murine Cytomegalovirus and Interferon in Macrophages

“…The neutralization of MCMV-M~b IFN by anti-IFNs indicated that the IFN was IFN-~/fl. These results are similar to studies which examined the ability of MCMV to induce IFN in MEF cultures (Henson & Smith, 1964;Oie et al, 1975), and confirm that murine Mq~ could synthesize IFN-ct/fl in response to exposure to viruses in vitro (Azuma, 1976;Lagwinska et al, 1975;T~ilas et al, 1973;Tsukui, 1977).…”

“…However, no inhibitors of MCMV replication have been detectable in uninfected Me cultures (Mims & Gould, 1978;Vaczi et al, 1966). Other viruses such as NDV (Isaacs & Baron, 1960;Tfilas et al, 1973), lactate dehydrogenase-elevating virus (Lagwinska et al, 1975) and influenza virus (Ettensohn & Roberts, 1984;Tsukui, 1977) have been shown to be able to infect mouse Mth and induce IFN production. Because of the findings with these other viruses, studies designed to elucidate the mechanisms regulating the delay and the limited production of MCMV after infection focused on IFN production by MCMV-infected M~b.…”

“…In those studies, intact resident M~b known to be deficient -in production of various monokines including lysozyme, lysosomal enzyme and interferon (IFN) were utilized. Since activated and virus-infected M~b (Azuma, 1976;Ettensohn & Roberts, 1984;Glasgow & Habel, 1963;Lagwinska et al, 1975;Tfilas et al, 1973;Tsukui, 1977) have been shown to produce substantial amounts of IFN in vitro, in order to understand the mechanism of the decreased production and delayed spread of MCMV in M~b cultures, the antiviral functions in MCMVinfected M~b cultures should be examined. Preliminary experiments in this laboratory revealed that MCMV-infected M~b inhibited vesicular stomatitis virus (VSV) production by L-929 cells and that the inhibition was eliminated by anti-IFN-cc/fl.…”

Role of Interferon in the Augmented Resistance of Trehalose-6,6'-dimycolate-treated Mice to Influenza Virus Infection

“…Tsukui (1977) demonstrated that T-lymphocytes are the main interferon producer in response to influenza virus. Table 2 shows that the enhanced interferon production was greatly diminished by treatment of mice with ATMA, suggesting that T-lymphocytes play a major role in interferon production in response to influenza virus; this is in agreement with the report of Tsukui and our earlier report using ectromelia virus-infected mice (Sakuma et al, 1983).…”

Rheumatoid arthritis--a virus disease?

“…The effects on the specific antiviral response may be long lasting. T lymphocytes specifically cytotoxic for infected cells are not generated in mice infected with lymphocytic choriomeningitis virus when the potentially responding cells are exposed to a high level of syngeneic cells infected with this virus (Dunlop and Blanden, 1977 (Tsukui, 1977). The capacity of mice to produce interferon in response to interferon inducers becomes progressively impaired during the course of persistent infections with several viruses such as encephalomyocarditis virus and influenza A2 virus (Stringfellow, et al, 1977 al., 1977).…”