Role of Interferon in the Augmented Resistance of Trehalose-6,6'-dimycolate-treated Mice to Influenza Virus Infection

Role of gamma delta TCR+ lymphocytes in the augmented resistance of trehalose 6,6'-dimycolate-treated mice to influenza virus infection.

“…Our analysis favoured a role for T-lymphocytes in conferring high resistance upon TDM-treated mice to influenza virus infection (Azuma et al, 1987(Azuma et al, , 1988. We therefore investigated the relative contribution of T-cell subsets to this acquired resistance in mice depleted of γδ or αβ T-cells by the in vivo administration of anti-γδ or anti-αβ TCR MAbs, respectively.…”

“…TDM prepared from Mycobacterium tuberculosis was purchased from Sigma. An oil-in-water emulsion of TDM (50 µg TDM in 200 µl emulsion) and a control emulsion were prepared as described by Azuma et al (1987). Mice were inoculated intravenously with 200 µl of either TDM or control emulsion 10 days before virus infection.…”

“…We have previously shown that NK cell activity markedly increased in TDM-treated and influenza virus-infected mice, suggesting that the NK cells participated in the resistance of these mice (Azuma et al, 1987). Since NK cells are essential participants in the defence against most virus infections, we performed experiments in vivo to determine whether the inoculation of anti-asialo GM1 serum had any adverse effect on the acquired resistance of TDM-treated mice to lethal influenza virus infection.…”

“…We have shown that mice inoculated intravenously with trehalose 6,6h-dimycolate (TDM), a glycolipid component of the mycobacterial cell wall, acquired high resistance to lethal influenza virus infection, involving the activation of macrophages and T-lymphocytes and resulting in earlier than normal interferon alpha\beta (αβ) production by these cells in response to the infection (Azuma et al, 1987(Azuma et al, , 1988. We have also speculated that γδ T-cells that accumulate in the lungs of mice inoculated with TDM play a substantial role in the augmented resistance of these mice to influenza virus infection (Sazaki et al, 1992).…”

Microbiotechnology Based Surfactants and Their Applications

“…However, most research are centered around the bio-activity of trehalose lipid molecules that exhibit biomedical properties such as antimicrobial, antiviral (Azuma et al, 1987;Watanabe et al, 1999;Shao, 2011) and antitumor activities (Sudo et al, 2000;. Due to their functions in cell membrane interactions they can act as therapeutic agents (Zaragoza et al, 2009;Shao, 2011) or have an impact on the pathogenesis of causative agents of infections, such as those caused by pathogenic M. tuberculosis, Corynebacterium diphteriae, and the opportunistic pathogens, Mycobacterium avium, Mycobacterium intracellulare, Nocardia asteroides, Corynebacterium matruchotii, and Corynebacterium xerosis (Kuyukina and Ivshina, 2010).…”