Influenza Virus-specific T Cells Lead to Early Interferon   in Lungs of Infected Hosts: Development of a Sensitive Radioimmunoassay

Taylor, Patricia M.; Meager, Anthony; Askonas, Brigitte A.

doi:10.1099/0022-1317-70-4-975

Cited by 24 publications

(13 citation statements)

References 15 publications

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“…Effects of different bacterial components of L. plantarum KFCC11389P on serum parameters and immunity of SPF chickens exposed to LPAI (H9N2) at 5 d.p.i. virus titres in secretion and lung samples (Wyde et al, 1982;Taylor et al, 1989). However, the present study showed no relationship between higher IFN-g levels and lower viral gene titres.…”

Section: Resultscontrasting

confidence: 55%

“…Higher NO production and possibly overexpression of IFN-g could be related to the infection of LPAI. Previous studies reported that influenza virus causes hypercytokinemia post mortem in human cases (To et al, 2001). In addition, neuraminidase inhibitors known as the antiviral agent considerably decreased NO production in the IFN-g-stimulated murine macrophages and prevented IL-6, tumour necrosis factor-a and IFN-g responses in volunteers experimentally infected with H1N1 (Fritz et al, 1999;Kačergius et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

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Evaluation system for an experimental study of low-pathogenic avian influenza virus (H9N2) infection in specific pathogen free chickens using lactic acid bacteria,Lactobacillus plantarumKFCC11389P

Chon

Choi²,

Jeong

et al. 2008

Avian Pathology

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In low-pathogenic avian influenza (LPAI) virus, the effects of prophylactic oral administration of Lactobacillus plantarum KFCC11389P on immunity, viral loads and levels of nitric oxide and interferon-g in splenocytes from specific pathogen free (SPF) chickens were investigated. For in vitro screening of the antiviral effect, haemagglutination activities of four different lactic acid bacterial strains by direct contact with virus were measured. L. plantarum KFCC11389P only neutralized the virus on the SPF eggs. For in vivo studies, four groups of chickens were fed with various L. plantarum KFCC11389P bacterial components and were then challenged with LPAI virus at 28 days. Additionally, two control groups were used as negative (virus-unchallenged) control and positive (virus-challenged) control. We show that some parameters such as nitric oxide production in serum and splenic adherent cells and interferon-g levels in splenic cells from SPF chickens could be used for the evaluation of LPAI virus infection. This is the first report demonstrating the interferon-g production in cultured splenic mononuclear cells and nitric oxide production in serum as well as virus shedding in trachea and cloacae in LPAI virus-infected SPF chickens fed specific lactic acid bacterial components.

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Section: Resultscontrasting

confidence: 55%

Section: Resultsmentioning

confidence: 99%

Evaluation system for an experimental study of low-pathogenic avian influenza virus (H9N2) infection in specific pathogen free chickens using lactic acid bacteria,Lactobacillus plantarumKFCC11389P

Chon

Choi²,

Jeong

et al. 2008

Avian Pathology

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“…Thus, both IFN-␣/␤ and IFN-␥ are induced early in the airways of mice infected with different strains of influenza virus (27,40,58). More detailed information on the role of IFNs in influenza has been obtained from studies on infected mice depleted of IFN-␣/␤ or IFN-␥ either by treatment with antibodies to selectively inhibit extracellular interferon and/or by using mice unable to respond to IFN-␣/␤ or IFN-␥ due to gene disruption.…”

mentioning

confidence: 99%

The Role of Alpha/Beta and Gamma Interferons in Development of Immunity to Influenza A Virus in Mice

Price

Gaszewska-Mastarlarz

Moskophidis

2000

J Virol

180

142

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“…In our observation on Theiler's virus GD VII strain, endogenous interferon gamma (IFN-y) was produced in the brains and spinal cords of the infected mice (Kohanawa et al, 1993). IFN-T which is secreted by natural killer (NK) cells and T lymphocytes (Klavinskis et al, 1989;Taylor et al, 1989;Nakane et al, 1991) is an important cytokine in viral infections (Klavinskis et al, 1989;Leist et al, 1989;Smith et al, 1991;Lucin et al, 1992). In lymphocytic choriomeningitis virus infection, CD8 + lymphocytes and CD4 + lymphocytes which are protective against this virus produce endogenous IFN-y (Gessner et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Theiler's virus is eliminated by a gamma-interferon-independent mechanism in the brain

Kohanawa¹,

Nakane²,

Asano³

et al. 1994

Journal of Neuroimmunology

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The intravenous infection of Theiler's virus GD VII strain causes acute encephalomyelitis in infected mice. To determine the cellular mechanism of resistance and interferon (IFN)-gamma-producing cell populations, mononuclear cells isolated from tissues of the brain were analyzed by the flow cytometry method. Antibodies specific for CD3, CD4, CD8, T cell receptor (TCR)-alpha beta, and Asialo GM1 were used to deplete the corresponding cell populations in Theiler's virus-infected mice. CD4+ lymphocytes and CD8+ lymphocytes infiltrated in the brains of infected mice from 5 days postinfection (p.i.). The number of CD3+/TCR-gamma delta+ lymphocytes increased in the brains on Day 6 p.i. The elimination of CD3+ lymphocytes or CD4+ lymphocytes augmented viral replication and suppressed the production of IFN-gamma. The suppression of IFN-gamma production by anti-CD3 monoclonal antibody (mAb) persisted, although the suppression by anti-CD4 mAb was observed only on Day 6 p.i. The depletion of CD8+ lymphocytes as well as TCR-alpha beta+ lymphocytes also augmented the viral replication; however, it did not alter the production of IFN-gamma. Anti-Asialo GM1 antibody had no effect on viral replication and IFN-gamma production. These results indicate that T lymphocytes are important for eliminating Theiler's virus from the brain, CD3+/CD4+/CD8- lymphocytes and CD3+/TCR alpha beta-/CD4-/CD8- lymphocytes would produce IFN-gamma in brain. However, from the result on the experiment of the depletion of TCR-alpha beta+ lymphocytes, the defence mechanisms by T lymphocytes against Theiler's virus would be independent of endogenous IFN-gamma production.

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Influenza Virus-specific T Cells Lead to Early Interferon in Lungs of Infected Hosts: Development of a Sensitive Radioimmunoassay

Cited by 24 publications

References 15 publications

Evaluation system for an experimental study of low-pathogenic avian influenza virus (H9N2) infection in specific pathogen free chickens using lactic acid bacteria,Lactobacillus plantarumKFCC11389P

Evaluation system for an experimental study of low-pathogenic avian influenza virus (H9N2) infection in specific pathogen free chickens using lactic acid bacteria,Lactobacillus plantarumKFCC11389P

The Role of Alpha/Beta and Gamma Interferons in Development of Immunity to Influenza A Virus in Mice

Theiler's virus is eliminated by a gamma-interferon-independent mechanism in the brain

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