The boom-and-bust trajectory of the Argopecten purpuratus industry in Chile shows the progression from resource extraction (fishing) to production (aquaculture). This paper analyses the effects of environmental, economic, and scientific–technological factors. The influence of each factor on scallop production in Chile was reviewed for the period between the 1980s and 2020. The evaluation of the effects allows the visualisation of the industry’s productive evolution and reveals the current challenges. The occurrence of abrupt environmental disturbances, commercialisation under imperfect market configurations, and public and private efforts in scientific and technological advances have acted favourably on scallop production. However, an industry mainly focused on prices and high production volumes did not devote much effort to develop low-cost climate-resilient technologies. Today, economic challenges must be addressed by helping to reduce production costs and add economic value to products and by-products. Our results show that the industry must focus on low-cost technologies, the use of renewable energy, and the circularity of its processes. The environment ensures the capture of natural seeds and their adaptation to climate change. These challenges must not lose sight of the emerging effects of the COVID-19 pandemic.