Infrared detection of cocaine and street cocaine in saliva with a one-step extraction

Photonics of human saliva: potential optical methods for the screening of abnormal health conditions and infections

“…Hans et al carried out ATR-FTIR investigation of saliva to obtain spectral features of cocaine at around 1280 cm −1 and between 1760 and 1710 cm −1 with an LOD of ~10μg/ml (Hans et al 2012 ). An extended study reported by the same group has obtained a lower limit of ~1μg/ml (Hans et al 2014 ).…”

“…(Drugs) 1 SERS Detection of methamphetamine in saliva and urine 2020 [Hong et al 2020 ] L.O.D: nM 2 SERS Detection of morphine 2020 [Li et al 2020 ] 2.4×10 −4 ng / ml 3 SERS Tetrahydrocannabinol (THC) in human plasma and saliva 2019 [Sivashanmugan et al 2019a , b ] L.O.D: 1pM 4 SERS Tetrahydrocannabinol (THC) in saliva 2019 [Sivashanmugan et al 2019a , b L.O.D: 10 ppm 5 SERS Codeine and Fentanyl; in saliva and blood 2019 [Shende et al 2019 ] L.O.D: 0.5 μg/ml 6 SERS Plasmonic capsules based SERS: methamphetamine (MA), in human saliva 2019 [Su et al 2019 ] 67.4% 7 SERS Ultra-traces of cocaine 2018 [D’Elia et al 2018 ] L.O.D: 10ng/ml 8 SERS Detection of drug-related biomarkers 2015 [Yang et al 2015 ] L.O.D: 100 nM 9 SERS Cocaine; in saliva. 2015 [Dana et al 2015 ] L.O.D: 25 ng/ml 10 SERS Illicit Drugs; in saliva 2014 [Shende et al 2014 ] _ 11 IR Cocaine in saliva 2014 [Hans et al 2014 ] L.O.D: 100 ng/ml 12 SERS methamphetamine 2013 [Andreou et al 2013 ] L.O.D: 10 nM ...…”

Cocaine detection in liquid using a fibered platform and a mid-infrared quantum cascade laser

“…The system was verified with a solution independently prepared at the Laser Spectroscopy and Sensing Lab at ETH Zürich, following a procedure previously reported [5]. The output of the valve was connected to the flow cell via an 80 cm long PTFE hose.…”

Spectroscopic Trends for the Determination of Illicit Drugs in Oral Fluid

“…Another study about the analysis of cocaine and street cocaine in oral fluid was made by Hans et al [35] and showed another important step towards the development of a compact, easyto-use, portable, quick and semi-quantitative screening device based on IR detection. In their previous work [30] they introduced the FTIR-ATR spectroscopy without sample preparation to study spectral interferences and to explore the LOD of cocaine in oral fluid.…”

“…According to these observations, authors stated that the developed device was simple to use, provided reproducible results in a short time (similar to that of the currently used immunoassays) and do not need of a bulk equipment. Thanks to these characteristics the device could be of great utility in roadside tests to obtain (semi-) quantitative results allowing the evaluation of the risk for impaired drivers [35].…”