Drying is an energy intensive and complex nonlinear process and it is difficult to control and make the traditional control meet the challenges. In order to effectively control the output grain moisture content of a combined infrared radiation and convection (IRC) grain dryer, taking into account the superiority of the fuzzy control method in dealing with complex systems, in this article, a genetic optimization dual fuzzy immune PID (Proportional-Integral-Derivative) (GODFIP) controller was proposed from the aspects of energy savings, stability, accuracy, and rapidity. The structure of the GODFIP controller consists of two fuzzy controllers, a PID controller, an immune algorithm, and a genetic optimization algorithm. In addition, a NARX model which can give relatively good predictive output information of the IRC dryer was established and used to represent the actual drying process to verify the control performance in the control simulation and anti-interference tests. The effectiveness of this controller was demonstrated by computer simulations, and the anti-interference performance comparative study with the other controllers further confirmed the superiority of the proposed grain drying controller which has the least value of performance objective function, the shortest rising time, and the best anti-interference ability compared to the other three compared controllers.