Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma

Li, Yan; Gobin, Andrew M; Dryden, Gerald W.; Xiao, Deyi; Li, Su Ping; Zhang, Guandong; Martin, Robert C.G.

doi:10.2147/ijn.s37140

Cited by 14 publications

(5 citation statements)

References 31 publications

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“…One specific formulation of nanoparticles of particular interest is gold-gold sulfide nanoparticles (GGS NP). To date, GGS NP have been investigated in pre-clinical studies spanning chemotherapy delivery to tumors [ 4 ] to immuno-targeted cancer therapy and imaging [ 5 – 8 ]. GGS NP are reportedly advantageous over other gold formulations due to their rapid and facile one-step synthesis, superior NIR absorption efficiency (98 %) and optimal size for accumulation within tumors in vivo [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Conventional One-Step Sodium Thiosulfate Facilitated Gold Nanoparticle Synthesis

et al. 2015

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Gold-gold sulfide nanoparticles are of interest for drug delivery, biomedical imaging, and photothermal therapy applications due to a facile synthesis method resulting in small particles with high near-infrared (NIR) absorption efficiency. Previous studies suggest that the NIR sensitivity of these nanoparticles was due to hexagonally shaped metal-coated dielectric nanoparticles that consist of a gold sulfide core and gold shell. Here, we illustrate that the conventional synthesis procedure results in the formation of polydisperse samples of icosahedral gold particles, gold nanoplates, and small gold spheres. Importantly, through compositional analysis, via UV/vis absorption spectrophotometry, transmission electron microscopy (TEM), and energy dispersive x-ray spectroscopy (EDS), we show that all of the nanoparticles exhibit identical face center cubic (FCC) gold crystalline structures, thus suggesting that sulfide is not present in the final fabricated nanoparticles. We show that icosahedrally shaped nanoparticles result in a blue-shifted absorbance, with a peak in the visible range. Alternatively, the nanoplate nanoparticles result in the characteristic NIR absorbance peak. Thus, we report that the NIR-contributing species in conventional gold-gold sulfide formulations are nanoplates that are comprised entirely of gold. Furthermore, polydisperse gold nanoparticle samples produced by the traditional one-step reduction of HAuCl4 by sodium thiosulfate show increased in vitro toxicity, compared to isolated and more homogeneous constituent samples. This result exemplifies the importance of developing monodisperse nanoparticle formulations that are well characterized in order to expedite the development of clinically beneficial nanomaterials.

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Section: Introductionmentioning

confidence: 99%

Characterization of Conventional One-Step Sodium Thiosulfate Facilitated Gold Nanoparticle Synthesis

et al. 2015

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“…In a study done by Li and group, chitosan-coated gold/gold sulfide nanoparticles were used to treat cancer. The results suggested the ablation of cancer cells upon near-infrared irradiation of accommodated gold nanoparticles [71]. A similar stimulus was used by another research group with an organic and inorganic hybrid system of titanium carbide nanoparticles coated on pluronic F127 hydrogel.…”

Section: Photo Responsivementioning

confidence: 55%

Responsive Nanostructure for Targeted Drug Delivery

Pawar

Maske

Khan

et al. 2023

JNT

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Currently, intelligent, responsive biomaterials have been widely explored, considering the fact that responsive biomaterials provide controlled and predictable results in various biomedical systems. Responsive nanostructures undergo reversible or irreversible changes in the presence of a stimulus, and that stimuli can be temperature, a magnetic field, ultrasound, pH, humidity, pressure, light, electric field, etc. Different types of stimuli being used in drug delivery shall be explained here. Recent research progress in the design, development and applications of biomaterials comprising responsive nanostructures is also described here. More emphasis will be given on the various nanostructures explored for the smart stimuli responsive drug delivery at the target site such as wound healing, cancer therapy, inflammation, and pain management in order to achieve the improved efficacy and sustainability with the lowest side effects. However, it is still a big challenge to develop well-defined responsive nanostructures with ordered output; thus, challenges faced during the design and development of these nanostructures shall also be included in this article. Clinical perspectives and applicability of the responsive nanostructures in the targeted drug delivery shall be discussed here.

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“…et al, 2021). Li et al (2013) used chitosan coated gold/gold sulfide (CS-GGS) NPs to treat EAC through endoscopic NIR irradiation. The results showed that this treatment method could selectively target cancer cells to achieve therapeutic effects without harming normal esophageal tissue.…”

Section: Figurementioning

confidence: 99%

Application and development of nanomaterials in the diagnosis and treatment of esophageal cancer

Xiao,

Zhang,

Zhao

et al. 2023

Front. Bioeng. Biotechnol.

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Esophageal cancer is a malignant tumor with a high incidence worldwide. Currently, there are a lack of effective early diagnosis and treatment methods for esophageal cancer. However, delivery systems based on nanoparticles (NPs) have shown ideal efficacy in real-time imaging and chemotherapy, radiotherapy, gene therapy, and phototherapy for tumors, which has led to their recent widespread design as novel treatment strategies. Compared to traditional drugs, nanomedicine has unique advantages, including strong targeting ability, high bioavailability, and minimal side effects. This article provides an overview of the application of NPs in the diagnosis and treatment of esophageal cancer and provides a reference for future research.

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Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma

Cited by 14 publications

References 31 publications

Characterization of Conventional One-Step Sodium Thiosulfate Facilitated Gold Nanoparticle Synthesis

Characterization of Conventional One-Step Sodium Thiosulfate Facilitated Gold Nanoparticle Synthesis

Responsive Nanostructure for Targeted Drug Delivery

Application and development of nanomaterials in the diagnosis and treatment of esophageal cancer

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