Infrared-Mediated Hyperthermia Is Effective in the Treatment of Scleroderma-Associated Raynaud's Phenomenon

Foerster, John; Fleischanderl, S.; Wittstock, Stefan; Storch, Annegret; Meffert, H; Riemekasten, Gabriela; Worm, Margitta

doi:10.1111/j.0022-202x.2005.23938.x

Cited by 16 publications

(26 citation statements)

References 12 publications

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“…Near-infrared water-filtered (IRA)-mediated mild hyperthermia was administered exactly as described [2]. Briefly, patients were placed on an Iratherm 1000 infrared-A bench (von Ardenne, Dresden, Germany; http://www.ardenne.de/med), and uniformally irradiated at 80% of maximal output (corresponding to 1000 W/m 2 ) for 30 min.…”

Section: Ira-mediated Hyperthermiamentioning

confidence: 99%

“…Using this device we could show that the response to cold challenge is indeed pathologically altered in primary as well as scleroderma-associated RP. Furthermore, when used to monitor the effect of infrared-mediated hyperthermia (IRA) on the severity of RP, measurement of the response to cold challenge detected a therapeutic effect of IRA independent, and in confirmation of clinical activity scores [2] thus demonstrating that this parameter is sensitive to change.…”

Section: Introductionmentioning

confidence: 98%

“…Treatment options for RP include a variety of vasodilatory drugs (reviewed in [1]), or physical treatments such as infrared-mediated hyperthermia [2]. Since none of the currently available therapies effectively cure or at least vastly improve RP in the majority of patients, clinical trials of novel therapies are on-going world-wide.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A cold-response index for the assessment of Raynaud's phenomenon

Foerster

Kuerth²,

Niederstrasser³

et al. 2007

Journal of Dermatological Science

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Section: Ira-mediated Hyperthermiamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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A cold-response index for the assessment of Raynaud's phenomenon

Foerster

Kuerth²,

Niederstrasser³

et al. 2007

Journal of Dermatological Science

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“…Several drugs are currently used to treat RP [3], despite their very limited effects and potentially adverse side effects. As recently described, infrared-mediated hyperthermia as physiotherapy showed positive effects on scleroderma-associated RP [4]. Deep oscillation is used as an additional therapy of lymphoedema and can supplement manual lymphatic drainage.…”

Section: Introductionmentioning

confidence: 90%

Effect of biofeedback and deep oscillation on Raynaud’s phenomenon secondary to systemic sclerosis: results of a controlled prospective randomized clinical trial

et al. 2011

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Our aim was to evaluate the effect of deep oscillation and biofeedback on Raynaud's phenomenon (RP) secondary to systemic sclerosis (SSc). A prospective randomized study was performed in SSc patients receiving either deep oscillation (n = 10) or biofeedback (n = 8) thrice a week for 4 weeks, or patients were randomized into the waiting group untreated for vasculopathy (n = 10) in time of running the study interventions. Biofeedback resulted in an improvement of RP as determined by score reduction of visual analogue scale compared with patients of the control group (P < 0.05), whereas deep oscillation revealed a tendency for improvement (P = 0.055). The study underlines the beneficial role of physiotherapy for the treatment of SSc-related RP.

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“…Interestingly, only treatment regimens including cyclophosphamide, UVA1 or methotrexate have led to a significant reduction in skin sclerosis thus far [3,4,5]. Wienert et al [6] and Foerster et al [7] described infrared A (IRA) to be therapeutically effective in the treatment of scleroderma-associated Raynaud‘s phenomenon and suggested that IRA could also be helpful in other forms of cutaneous scleroderma. Geissler and Schumann described a case of an ulcerative morphea of the lower leg which was successfully treated with water-filtered IRA plus visible light [wIRA(+VIS)] [8].…”

Section: Introductionmentioning

confidence: 99%

Irradiation with Water-Filtered Infrared A plus Visible Light Improves Cutaneous Scleroderma Lesions in a Series of Cases

et al. 2011

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Background: Cutaneous scleroderma is a chronic inflammatory disease of the dermal and subcutaneous connective tissue leading to sclerosis. Sclerosis of the skin can lead to dysmorphism, contractures and restrictions of movement. Objective: The purpose of the study was to evaluate sclerosis in cutaneous scleroderma patients and to determine the efficacy of water-filtered infrared A plus visible light treatment, wIRA(+VIS), in 10 patients. Methods: Hardness of the normal and diseased skin was measured by durometry in 10 controls and 8 patients. Moreover, circumscribed scleroderma (CS) was treated with wIRA(+VIS) irradiations in 10 patients who had not responded to conventional therapies. Results: wIRA(+VIS) therapy led to a marked improvement, persistent even during long-term follow-up, in 7 out of 10 patients with CS. Of the other patients, 1 showed decreased sclerosis and disease activity and developed a worsening after cessation of therapy. In 2 further patients, where previous UVA1 treatment had failed to reduce disease activity, wIRA(+VIS) produced a slight decrease in sclerosis, but disease activity was still present. Conclusion: wIRA(+VIS) appears to be effective in the treatment of CS. Durometry proved to be helpful in assessing the degree of sclerosis and in documenting the response to therapy in these patients.

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Infrared-Mediated Hyperthermia Is Effective in the Treatment of Scleroderma-Associated Raynaud's Phenomenon

Cited by 16 publications

References 12 publications

A cold-response index for the assessment of Raynaud's phenomenon

A cold-response index for the assessment of Raynaud's phenomenon

Effect of biofeedback and deep oscillation on Raynaud’s phenomenon secondary to systemic sclerosis: results of a controlled prospective randomized clinical trial

Irradiation with Water-Filtered Infrared A plus Visible Light Improves Cutaneous Scleroderma Lesions in a Series of Cases

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